Determination of bisphenols with estrogenic activity in plastic packaged baby food samples using solid-liquid extraction and clean-up with dispersive sorbents followed by gas chromatography tandem mass spectrometry analysis

García-Córcoles, María Teresa; Çipa, Morsina; Rodríguez-Gómez, R.; Rivas, Ana; Olea‐Serrano, F.; Vı́lchez, J.L.; Zafra-Gómez, Alberto

doi:10.1016/j.talanta.2017.09.067

Cited by 108 publications

(47 citation statements)

References 35 publications

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“…As can be seen, the chromatograms are clear, which means that the extraction procedure is effective and that the peaks are sharp and well resolved. For a complete analytical characterization, a comparison was carried out between our main results and those reported in the literature; in particular, recoveries, LODs and LOQs were compared between different studies performed in the last decade for the simultaneous analysis of PAEs and BPA in food/beverage matrices [51][52][53][71][72][73][74][75][76][77][78] (Table 4). As can be seen, the main basic PAEs analyzed in most papers are DEP, DBP, and DEHP together with BPA, whereas only a few papers show a more complete PAE speciation.…”

Section: Analytical Protocol Parametersmentioning

confidence: 99%

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

et al. 2019

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Phthalates (or phthalate esters, PAEs) and bisphenol A (BPA) are widely used in various industries, particularly in the fields of cosmetics and packaging, and they increase the malleability and workability of materials. As a result of their use, some international health organizations have begun to study them. In this study, the authors developed a methodology for the simultaneous determination of dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP); dibutyl phthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP); di-n-octyl-phthalate (DnOP) and bisphenol A (BPA) from drinking and non-potable waters. The extraction of PAEs and BPA was performed using a solvent-based dispersive liquid–liquid microextraction (SB-DLLME) method. The analytical determination was performed using a gas chromatography–ion trap mass spectrometry (GC-IT/MS) analysis. The entire procedure was validated as recoveries were studied according to the volume and the extraction solvent used, pH, and ionic strength. Dynamic linearity ranges and linear equations of all the compounds were experimentally determined as well as the limit of detection (LOD) (1–8 ng mL−1) and the limit of quantification (LOQ) (5–14 ng mL−1), reproducibility, and sensitivity. The method was applied to 15 water samples (mineral water and tap water) for determining PAEs and BPA released from the plastic container. After the release simulation, four PAEs (i.e., DiBP, DBP, DHEP, and DnOP) were determined at very low concentrations (below 1.2 ng mL−1) in two water samples from (sport) bottles.

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Section: Analytical Protocol Parametersmentioning

confidence: 99%

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

et al. 2019

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“…In 2017, BPA was identified as a very high concern substance in the list of the European Chemical Agency (ECHA). Regarding the recent regulations that further restrict the use of BPA in food contact materials [5], food packaging companies are exploring substitutes for the purpose of gradually eliminating BPA from their products [6].…”

Section: Introductionmentioning

confidence: 99%

Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice

et al. 2020

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Background: Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, particularly during perinatal period (gestation and/or lactation). We previously demonstrated that perinatal oral exposure to BPA (via gavage of mothers during gestation and lactation) has long-term consequences on immune response and intestinal barrier functions. Due to its adverse effects on several developmental and physiological processes, BPA was removed from consumer products and replaced by chemical substitutes such as BPS or BPF, that are structurally similar and not well studied compare to BPA. Here, we aimed to compare perinatal oral exposure to these bisphenols (BPs) at two doses (5 and 50 μg/kg of body weight (BW)/day (d)) on immune response at intestinal and systemic levels in female offspring mice at adulthood (Post Natal Day PND70). Methods: Pregnant female mice were orally exposed to BPA, BPS or BPF at 5 or 50 μg/kg BW/d from 15th day of gravidity to weaning of pups at Post-Natal Day (PND) 21. Humoral and cellular immune responses of adult offspring (PND70) were analysed at intestinal and systemic levels. Results: In female offspring, perinatal oral BP exposure led to adverse effects on intestinal and systemic immune response that were dependant of the BP nature (A, S or F) and dose of exposure. Stronger impacts were observed with BPS at the dose of 5 μg/kg BW/d on inflammatory markers in feces associated with an increase of anti-E. coli IgG in plasma. BPA and BPF exposure induced prominent changes at low dose in offspring mice, in term of intestinal and systemic immune responses, provoking an intestinal and systemic Th1/Th17 inflammation. Conclusion: These findings provide, for the first time, results of long-time consequences of BPA, S and F perinatal exposure by oral route on immune response in offspring mice. This work warns that it is mandatory to consider immune markers and dose exposure in risk assessment associated to new BPA's alternatives.

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“…One of these threatening factors is an endocrine disrupting chemical (EDC) which is known as bisphenol A (BPA). Even though BPA has a teratogenic effect on embryos during their critical period of organogenesis (16) unfortunately some of the bisphenol derivatives are found in for example at babies nursing bottles and pacifiers (17). According to a BPA research related to fetal health, women who were exposed to the highest BPA had the lowest estimated growth rates for fetal head circumference.…”

Section: Potential Teratogen Effects Of Bpa At Prenatal Development Smentioning

confidence: 99%

Bisphenol A and Male Reproductive System

Amraje¹,

Köylü²,

Dizakar³

et al. 2018

GMJ

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Bisphenol A (BPA) is an alkylphenol endocrine disruptor chemical (EDC). It is a building block for polycarbonate (PC) plastics and epoxy resins and it is used in food packaging, canned foods, baby bottles, baby food jars and medical devices. Recently, researchers have shown an increased interest in BPA and its effect on reproduction, neurodevelopment and metabolism. The experimental data are rather controversial, and there is no general consensus about BPA's effects. In this review, potential impacts of the BPA on male reproductive system in prenatal and postnatal period are summarized.

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Determination of bisphenols with estrogenic activity in plastic packaged baby food samples using solid-liquid extraction and clean-up with dispersive sorbents followed by gas chromatography tandem mass spectrometry analysis

Cited by 108 publications

References 35 publications

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice

Bisphenol A and Male Reproductive System

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