Determination of bisphenol A in milk by solid phase extraction and liquid chromatography–mass spectrometry

Maragou, Niki C.; Lampi, Eugenia; Thomaidis, Nikolaos S.; Koupparis, Michael A.

doi:10.1016/j.chroma.2006.06.103

Cited by 168 publications

(75 citation statements)

References 37 publications

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“…It most probably owes to the LVI mode which enhances the method sensitivity. Besides, the proposed method introduces less matrix effect than the traditional one, because no significant signal suppression was observed while only 52% of recovery without internal standard was obtained by traditional method [16].…”

Section: Methods Performancementioning

confidence: 99%

“…Compared to traditional off-line SPE coupled with HPLC-single quadruple MS method [16], lower LODs could be obtained in this method. It most probably owes to the LVI mode which enhances the method sensitivity.…”

Section: Methods Performancementioning

confidence: 99%

“…According to the report from National Toxicology Program (NTP), the low-level exposure to BPA during development can cause changes in behavior and the brain, prostate gland, mammary gland, and the age at which females attain puberty. For this reason, increasing attention has been paid on BPA in milk in academic field and a lot of extraction methods has been developed, including solid-phase extraction (SPE) [16], molecularly imprinted polymers (MIPs) [17] and matrix solid-phase dispersion (MSPD) [18].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of estrogens and bisphenol A in bovine milk by automated on-line C30 solid-phase extraction coupled with high-performance liquid chromatography–mass spectrometry

Yan

Zhao

et al. 2009

Journal of Chromatography A

107

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a b s t r a c tUsing triacontyl bonded silica (C 30 ) as on-line solid-phase extraction (SPE) material and a specially designed on-line analytical system which allowed large sample volume injection, a high speed and robust on-line SPE-HPLC-MS method was established for the analysis of five estrogens and bisphenol A (BPA) in milk samples. The milk sample is pretreated with acetonitrile for protein precipitation and then treated with primary secondary amine for the removal of polar impurities in the matrix. Then the pretreated sample can be automatically loaded by a LC pump. For effective extraction, an offshoot with NH 4 Ac solution of high-flow rate was employed to dilute the loaded sample by a mixing tee before sample was loaded onto the C 30 extraction column. In this way, large volume injection (1 mL in this experiment) could be achieved. Some important parameters such as sample loading flow rate, sample dilution ratio and injection volume were optimized. Under the optimized conditions, the recoveries for all analytes range from 71.4 to 97.1% and reproducibility represented as RSDs are less than 15.0% (n = 5) with milk samples spiked at 0.6 and 15 ng/mL of each analyte. To the authors' knowledge, it constitutes the first work describing a C 30 on-line SPE-LC-MS analytical method for the screen and monitoring of these estrogens and BPA in milk.

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Section: Methods Performancementioning

confidence: 99%

Section: Methods Performancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of estrogens and bisphenol A in bovine milk by automated on-line C30 solid-phase extraction coupled with high-performance liquid chromatography–mass spectrometry

Yan

Zhao

et al. 2009

Journal of Chromatography A

107

View full text Add to dashboard Cite

show abstract

“…Identification of BPA was carried out according to a method described previously (Maragou et al 2006). A Thermo Finnigan LC-MS system (San Jose, USA) consisted of a Spectra System P 4000 pump, a Spectra System AS 3000 autosampler with the volume injection set to 10 µl was used with a Surveyor MSQ quadrupole mass spectrometer equipped with an electrospray ionization LC-MS interface (ESI).…”

Section: Lc-ms Analysismentioning

confidence: 99%

Migration of bisphenol A from polycarbonate baby bottles under real use conditions

Maragou¹,

Makri²,

Lampi³

et al. 2008

Food Additives & Contaminants: Part A

Self Cite

119

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“…C18 proved to be the most suitable sorbent for isolation of analyte. The concentration of bisphenol A in milk and powdered infant formula samples determined by LC-MS were between and below LOD to 15.2 ng/g [30].…”

Section: Non-selective Sorbentsmentioning

confidence: 99%

Extraction Techniques for Isolation, Purification and Preconcentration of Bisphenols and Alkylphenols from Environmental and Food Samples

Arivoli¹,

Arasakumar²

2017

International Journal of Advanced Research in Chemical Science

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Determination of bisphenol A in milk by solid phase extraction and liquid chromatography–mass spectrometry

Cited by 168 publications

References 37 publications

Determination of estrogens and bisphenol A in bovine milk by automated on-line C30 solid-phase extraction coupled with high-performance liquid chromatography–mass spectrometry

Determination of estrogens and bisphenol A in bovine milk by automated on-line C30 solid-phase extraction coupled with high-performance liquid chromatography–mass spectrometry

Migration of bisphenol A from polycarbonate baby bottles under real use conditions

Extraction Techniques for Isolation, Purification and Preconcentration of Bisphenols and Alkylphenols from Environmental and Food Samples

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