Determination of biological activity of Tragopogon porrifolius and Polygonum cognatum consumed intensively by people in Sivas

Eruygur, Nuraniye; Uçar, Esra; Ataş, Mehmet; Ergül, Mustafa; Sözmen, Fazlı

doi:10.1016/j.toxrep.2019.12.002

Cited by 14 publications

(11 citation statements)

References 38 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Using this program, ranges matching 95% of known drugs are taken into account and the properties of a particular molecule are predicted. Qik-Prop also includes values similar to Lipinski rules: MW (130.0-725.0), octanol/water partition coefficient log P (−2-6.5), number of HBDs (0-6), number of hydrogen bond acceptors (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Compounds that satisfy these rules are considered druglike.…”

Section: The Results Of In Silico Analysesmentioning

confidence: 99%

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Akpınar,

Yıldırım Baştemur,

Bıçak

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

Polygonum cognatum Meissn, a perennial herbaceous belonging to the Polygonaceae family, is an aromatic plant. High‐performance liquid chromatography/diode array detector method was developed and validated for the phytochemical analysis of the plant. Also, various methods were used to investigate the antioxidant, antimicrobial, and cytotoxic activities of the methanolic extracts. Antioxidant activities were researched by 2,2′‐diphenyl‐1‐picrylhydrazyl and cupric reducing antioxidant capacity methods. Among the tested standard microbial strains, Candida albicans was found to be more sensitive with a 24.60 ± 0.55 mm inhibition zone according to the diffusion tests. In the microdilution tests, the minimum inhibitory concentration and minimum bactericidal/fungicidal concentration values were 4.75 and ≥ 4.75 mg/mL, respectively, for all tested pathogens. Human colon carcinoma cells were used to investigate cytotoxicity by using 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyl tetrazolium bromide analysis (IC50 = 2891 μg/mL for Plant A, IC50 = 3291 μg/mL for Plant B). Molecular docking and absorption, distribution, metabolism, excretion, and toxicity analysis were used to explain inhibition mechanisms of major phenolic compounds of plants against Tankyrase 1, Tankyrase 2 enzymes, and deoxyribonucleic acid gyrase subunit B and found compatible with experimental results.

show abstract

Section: The Results Of In Silico Analysesmentioning

confidence: 99%

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Akpınar,

Yıldırım Baştemur,

Bıçak

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…This enzyme can increase the blood sugar level, as hydrolyses (1,4)-α- d -glycosidic linkages in polysaccharides contain three or more (1,4)-α-linked D-glucose units. Another study demonstrated that the EtOH extract of P. cognatum strongly inhibited α-amylase activity (86.6%) and moderately inhibited α-glucosidase activity (41.05%) with respect to the standard acarbose (58.4% and 57.56%, respectively) [ 169 ].…”

Section: Pharmacological Activities Of Persicaria and Polygonum Products: Different Type Of Extractmentioning

confidence: 99%

An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum

et al. 2021

View full text Add to dashboard Cite

The discovery of new pharmaceutical identities, particularly anti-infective agents, represents an urgent need due to the increase in immunocompromised patients and the ineffectiveness/toxicity of the drugs currently used. The scientific community has recognized in the last decades the importance of the plant kingdom as a huge source of novel molecules which could act against different type of infections or illness. However, the great diversity of plant species makes it difficult to select them with probabilities of success, adding to the fact that existing information is difficult to find, it is atomized or disordered. Persicaria and Polygonum constitute two of the main representatives of the Polygonaceae family, which have been extensively used in traditional medicine worldwide. Important and structurally diverse bioactive compounds have been isolated from these genera of wild plants; among them, sesquiterpenes and flavonoids should be remarked. In this article, we firstly mention all the species reported with pharmacological use and their geographical distribution. Moreover, a number of tables which summarize an update detailing the type of natural product (extract or isolated compound), applied doses, displayed bioassays and the results obtained for the main bioactivities of these genera cited in the literature during the past 40 years. Antimicrobial, antioxidant, analgesic and anti-inflammatory, antinociceptive, anticancer, antiviral, antiparasitic, anti-diabetic, antipyretic, hepatoprotective, diuretic, gastroprotective and neuropharmacological activities were explored and reviewed in this work, concluding that both genera could be the source for upcoming molecules to treat different human diseases.

show abstract

“…Hücre canlılığı, 24-48 saatlik inkübasyondan sonra hücrelerin mitokondriyal aktivitesinin, oldukça hassas WST-1 deneyi ile tayin edilmesi suretiyle belirlendi (Boivin, Blanchette, Barrette, Moghrabi, & Beliveau, 2007). Negatif kontrol olarak DMEM (% 0,5 DMSO içerir) kullanıldı (Eruygur et al, 2020). WST-1 hücre proliferasyon deneyleri sonucunda IC50 değerleri GraphPad Prism 6 programı kullanılarak hesaplandı (SARAÇ et al).…”

Section: Hücre Kültürüunclassified

Elazığ’da Yetişen Polygonum cognatum Meissn (Madımak) Bitki Ekstraktlarının In vitro Biyolojik Aktiviteleri ve Bazı Fitokimyasal Bileşenlerinin Belirlenmesi

Pekdemir

Çiftçi

Karatepe

2020

European Journal of Science and Technology

View full text Add to dashboard Cite

ÖzHalk arasında bitkilerin çeşitli kısımları kullanım amacına yönelik basit işlemlerden geçirilerek gerek gıda, gerekse tedavi amacıyla yaygın olarak kullanılmaktadır. Bitkiler, insan beslenmesinde çok önemli bir yer tutar ve insan sağlığı açısından bazı önemli bileşenler içermektedir. Dünyadaki bitkisel çeşitliliğin fazlalığı, çoğu bitkinin biyolojik etkileri ve etki mekanizmaları hakkındaki bilimsel verilerin hala yetersiz olması bu konuya olan ilgiyi her geçen gün artırmaktadır. Bu çalışmanın amacı, Elazığ yöresinden toplanan ve özellikle gıda olarak mevsiminde bolca tüketilen Polygonum cognatum Meissn (Madımak, Kuşekmeği) bitkisinin etanol, metanol, aseton ve hekzan ekstraktlarının antiradikal aktiviteleri, fitokimyasal bileşenleri, antimikrobiyal ve in vitro antikanserojen aktivitelerinin araştırılmasıdır. Çalışma sonuçlarımıza göre, P. cognatum Meissn özütlerinin ABTS radikal giderme aktivitelerinin DPPH a kıyasla daha iyi sonuç verdiği görüldü. Ayrıca ABTS radikal giderme aktivitelerinin standart bir antioksidan olan askorbik asite (Vitamin C) yakın değerlerde olduğu bulundu. Polygonum cognatum Meissn' in yüksek miktarda fitosteroller, K ve D vitaminleri, α-tokoferol, flavonoidler, proantosiyanidin, fenolikler ve doymamış yağ asitleri içerdiği tespit edilmiştir. Bitki ekstraktlarının antimikrobiyal etkileri Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans mikroorganizmaları kullanılarak Disk Difüzyon ve Minimum İnhibitör Konsantrasyonu (MİK) yöntemleri ile belirlendi. Bütün ekstraktların tüm mikroorganizmalara karşı antimikrobiyal aktivite gösterdiği görüldü. Aynı zamanda Polygonum cognatum Meissn ekstraktlarının, MCF-7, PC3 ve MKN-45 kanser hücre hatları üzerinde kontrole göre özellikle yüksek konsantrasyonlarda oldukça iyi sitotoksik etkiler sergilediği görüldü. Kanser hücreleri içerisinde en yüksek etkiyi ise MKN-45 (insan mide kanseri) hücre hattında göstermiştir. Elde edilen sonuçlar antioksidan ve antiproliferatif etki gösteren ve biyoaktif bileşikleri içeren Polygonum cognatum Meissn bitkisinin insanlar tarafından tüketilmeye devam edilebileceğini göstermiştir. AbstractAmong the people, various parts of the plants are passed through simple processes for their intended use and are widely used for both food and therapeutic purposes. Plants have a very important place in human nutrition and contain some important components in terms of human health. Excess of the global herbal diversity, the lack of the scientific data on the biologic effects and mechanism of action of most plants are increasing the interest in this issue day by day. The aim of this study, is to investigate the antiradical activities, phytochemical components, antimicrobial and in vitro anticancer activities of the ethanol, methanol, acetone and hexane extracts of the Polygonum cognatum Meissn (Madımak, Kuşekmeği) collected from Elazığ and consumed abundantly as a food in season. According to our study results, ABTS radical scavenging activities of Polygonum cognatum Meissn extracts...

show abstract

Determination of biological activity of Tragopogon porrifolius and Polygonum cognatum consumed intensively by people in Sivas

Abstract: Graphical abstract

Cited by 14 publications

References 38 publications

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum

Elazığ’da Yetişen Polygonum cognatum Meissn (Madımak) Bitki Ekstraktlarının In vitro Biyolojik Aktiviteleri ve Bazı Fitokimyasal Bileşenlerinin Belirlenmesi

Contact Info

Product

Resources

About