Determination of biogenic amines in the water flea, Daphnia magna (Cladocera, Crustacea) and their diurnal variations using ion-pair reversed phase hplc with electrochemical detection

Ehrenström, Fredrik; Berglind, Rune

doi:10.1016/0742-8413(88)90108-9

Cited by 18 publications

(16 citation statements)

References 24 publications

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“…Despite that the studied pharmaceuticals affected reproduction and behaviour at similar concentrations, existing experimental evidence is too limited to hypothesized that both responses may share a common mechanisms of action. In crustaceans and in particular in Daphnia serotonin together with dopamine and other ammines regulate behaviour responses to light (Christie and McCoole, 2012;Ehrenström and Berglind, 1988;Fong and Ford, 2014;Strauss and Dircksen, 2010). If fluoxetine increases serotonin activity in D. magna (Campos et al, 2012a), then it is likely that by doing so also alters its response to light stimulus.…”

Section: Discussionmentioning

confidence: 98%

“…These include the presence of serotonin, dopamine, epinephrine and GABA receptor signalling pathways (Campbell et al, 2004;Campos et al, 2013b;Ehrenström and Berglind, 1988;McCoole et al, 2012a,b;Weiss et al, 2012). There is also evidence that the SSRI fluoxetine, carbamazepine and propranolol increase offspring production at 10, 1 and 50 g/L, respectively (Campos et al, 2012a;Lürling et al, 2006;Stanley et al, 2006).…”

Section: Introductionmentioning

confidence: 91%

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Low environmental levels of neuro-active pharmaceuticals alter phototactic behaviour and reproduction in Daphnia magna

2016

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 91%

Low environmental levels of neuro-active pharmaceuticals alter phototactic behaviour and reproduction in Daphnia magna

2016

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“…Acute carbamazepine exposure also resulted in significant decreases in the aromatic amino acids tryptophan, phenylalanine and tyrosine; phenylalanine revealed significant (p < 0.05) decreases with 1.75, 5.25, 7 and 10.5 mg/L carbamazepine exposures while tyrosine significantly (p < 0.05) decreased at ≤ 10.5 mg/L exposures and tryptophan significantly (p < 0.05) decreased at ≤ 7 mg/L exposures ( Figure 5). Tryptophan is a precursor for serotonin in D. magna (Campos et al, 2013) and phenylalanine is an essential amino acid and is the precursor to tyrosine, which is in turn involved in the production of the catecholamine neurotransmitters L-DOPA, dopamine, norepinephrine and epinephrine in D. magna (Ehrenström and Berglind, 1988). The significant decrease in the aromatic amino acids with acute carbamazepine exposure suggests an altered synthesis of their neurotransmitter derivatives and corresponding disturbances in dopaminergic and serotonergic signaling.…”

Section: Nmr-based Metabolomics Of Carbamazepine Exposurementioning

confidence: 99%

1H NMR-based metabolomics of Daphnia magna responses after sub-lethal exposure to triclosan, carbamazepine and ibuprofen

Kovacevic¹,

Simpson²,

Simpson³

2016

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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Pharmaceuticals and personal care products are a class of emerging contaminants that are present in wastewater effluents, surface water, and groundwater around the world. There is a need to determine rapid and reliable bioindicators of exposure and the toxic mode of action of these contaminants to aquatic organisms. (1)H nuclear magnetic resonance (NMR)-based metabolomics in combination with multivariate statistical analysis was used to determine the metabolic profile of Daphnia magna after exposure to a range of sub-lethal concentrations of triclosan (6.25-100μg/L), carbamazepine (1.75-14mg/L) and ibuprofen (1.75-14mg/L) for 48h. Sub-lethal triclosan exposure suggested a general oxidative stress condition and the branched-chain amino acids, glutamine, glutamate, and methionine emerged as potential bioindicators. The aromatic amino acids, serine, glycine and alanine are potential bioindicators for sub-lethal carbamazepine exposure that may have altered energy metabolism. The potential bioindicators for sub-lethal ibuprofen exposure are serine, methionine, lysine, arginine and leucine, which showed a concentration-dependent response. The differences in the metabolic changes were related to the dissimilar modes of toxicity of triclosan, carbamazepine and ibuprofen. (1)H NMR-based metabolomics gave an improved understanding of how these emerging contaminants impact the keystone species D. magna.

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“…The sample preparation and analysis, including all chemicals used for the extraction of CA's and IND's, standards, mobile phases, and their preparation, mainly followed the methods described by Ehrenstr6m and Johansson (1985) and Ehrenstr6m and Berglind (1988), with the following modifications:…”

Section: Biochemical Analysesmentioning

confidence: 99%

“…Analytical routines were according to Ehrenstr6n and Johansson (1985) and Ehrenstr6m and Berglind (1988) and calculations were performed using the pre-programmed internal standard methods of the integrators. All calculations refer to free base of CA or IND.…”

Section: Analytical Routines and Calculationsmentioning

confidence: 99%

The yohimbine-induced anticonflict effect in the rat, part II. Neurochemical findings

Söderpalm

Ehrenström

Söderpalm

1995

J. Neural Transmission

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In a companion paper the alpha 2-adrenoceptor antagonist yohimbine was found to produce a dose-dependent anticonflict effect in a modified Vogel's conflict test. The behavioral data further indicated that noradrenergic and serotonergic neurons as well as the benzodiazepine (BDZ) receptor may be involved in the anticonflict effect of yohimbine. In the present study the effects on rat brain monoamine neurochemistry and GABAA/BDZ receptor function (36Cl-uptake in corticohippocampal synaptoneurosomes) of a maximally anticonflict producing dose of yohimbine (4.0 mg/kg, i.p.) were studied. The levels of rat brain catecholamines and indoleamines were measured ex vivo using high performance liquid chromatography with electrochemical detection (HPLC-ED). Yohimbine decreased noradrenaline levels both in the hippocampus and the hemispheres but instead increased DOPAC levels in these brain regions as well as in the limbic forebrain. Yohimbine also markedly enhanced DOPA accumulation in the hippocampus and the hemispheres after inhibition of 1-aromatic amino acid decarboxylase by means of NSD 1015, whereas in the limbic system only a modest increase was obtained. The yohimbine-induced effects on the catecholamine synthesis rate were largely abolished in animals severely depleted of NA by means of 6-hydroxy-dopamine (6-OH-DA) pretreatment. Yohimbine decreased both the 5-HIAA/5-HT quotient (an indicator of 5-HT turnover) and 5-HTP accumulation after NSD 1015 in the hemispheres, whereas in the hippocampus and the limbic system only 5-HTP accumulation was decreased. The yohimbine-induced effect on the indoleamine synthesis rate was not influenced by 6-OH-DA pretreatment, whereas this effect and that on the catecholamine synthesis rate were both abolished by reserpine pretreatment. Neither in vivo nor in vitro administration of yohimbine significantly altered baseline or GABA-induced accumulation of 36Cl- in corticohippocampal synaptoneurosomes. In conclusion, the present study provides neurochemical support for the suggestion that yohimbine may exert its anticonflict effect in a modified Vogel's conflict test by increasing and decreasing NA and 5-HT neurotransmission, respectively, whereas no evidence was obtained for a direct interaction of yohimbine with GABAA/BDZ receptor function.

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Determination of biogenic amines in the water flea, Daphnia magna (Cladocera, Crustacea) and their diurnal variations using ion-pair reversed phase hplc with electrochemical detection

Cited by 18 publications

References 24 publications

Low environmental levels of neuro-active pharmaceuticals alter phototactic behaviour and reproduction in Daphnia magna

Low environmental levels of neuro-active pharmaceuticals alter phototactic behaviour and reproduction in Daphnia magna

1H NMR-based metabolomics of Daphnia magna responses after sub-lethal exposure to triclosan, carbamazepine and ibuprofen

The yohimbine-induced anticonflict effect in the rat, part II. Neurochemical findings

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