Abstract:Abstract-We set up a system to measure the luminal pH, potential difference (PD) and bicarbonate output in the anesthetized rat duodenum, and investigated these responses caused by prostaglandins (PGs) and cholinergic agents. When the proximal duodenum (1.7 cm) was perfused at a flow rate of 0.7 ml/min with saline adjusted to pH 4.5, the duodenal pH, PD and HC03 output were 5.5 to 6.0, -4 to -6 mV and 1 .2 to 1.6 aEq/10 min, respectively; they were markedly reduced by i.v.injection of saturated KCI. Both natur… Show more
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