Determination of arterial wall shear stress

Liu, Zhaorong; He, Feng; Xu, Gang; Chen, Yong

doi:10.1007/bf02877020

Cited by 6 publications

(10 citation statements)

References 4 publications

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“…Several studies demonstrated that the case of high CS together with low WSS are associated with vascular diseases such as hypertension and atherosclerosis [13,20]. The above case (high CS and low WSS) will lead to a higher Zs.…”

Section: Discussionmentioning

confidence: 97%

“…There were only few numerical studies that treated both CS and WSS simultaneously [5,[17][18][19][20]. It is worthy of note that most of previous studies were focused on the hemodynamics in the local districts, such as short segments of straight arteries [8,10,[13][14][15][16], bifurcations [5,[20][21][22], bendings [19], stenosis [23], and anastomoses [18], and emphases were laid on the influence of local geometry and local mechanical property of arterial walls on the local blood flow patterns, providing powerful local hemodynamic evidences to explain the high localization of artherosclerotic plaque. Nevertheless, most of these studies have ignored the effects of other parts of circulatory In physiological conditions in vivo, the blood pressure or the flow does not independently act but interacts with each other in the circulatory system, thus the wall shear stress induced by blood flow and the circumferential stress due to blood pressure will not independently, but interdependently, act on the arterial endothelium.…”

Section: Introductionmentioning

confidence: 98%

“…A number of methods to determine CS or WSS have been proposed in recent years. Most of these methods have been confined to either CS ignoring WSS [7][8][9][10][11][12], or WSS ignoring CS [13][14][15][16]. There were only few numerical studies that treated both CS and WSS simultaneously [5,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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A multiscale model for analyzing the synergy of CS and WSS on the endothelium in straight arteries

et al. 2006

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A multiscale model was proposed to calculate the circumferential stress (CS) and wall shear stress (WSS) and analyze the effects of global and local factors on the CS, WSS and their synergy on the arterial endothelium in large straight arteries. A parameter pair [Zs, SP A] (defined as the ratio of CS amplitude to WSS amplitude and the phase angle between CS and WSS for different harmonic components, respectively) was proposed to characterize the synergy of CS and WSS. The results demonstrated that the CS or WSS in the large straight arteries is determined by the global factors, i.e. the preloads and the afterloads, and the local factors, i.e. the local mechanical properties and the zero-stress states of arterial walls, whereas the Zs and SP A are primarily determined by the local factors and the afterloads. Because the arterial input impedance has been shown to reflect the physiological and pathological states of whole downstream arterial beds, the stress amplitude ratio Zs and the stress phase difference SP A might be appropriate indices to reflect the influences of the states of whole downstream arterial beds on the local blood flow-dependent phenomena such as angiogenesis, vascular remodeling and atherosgenesis.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

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A multiscale model for analyzing the synergy of CS and WSS on the endothelium in straight arteries

et al. 2006

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“…For a Newtonian fluid flow, the shear stress is given by Using equations (1) and (2), we get the well-known calculation of shear stress 8,9,17,19 :…”

Section: Shear Stress In Steady Flowmentioning

confidence: 99%

“…Equations (3) and (4) are well-established formulae 8,9,17,19 . These form a foundational law that must be adhered to in the experiment.…”

Section: Shear Stress In Pulsatile Flowmentioning

confidence: 99%

An apparatus for studying the response of cultured

Shen

Qiao

Ding

et al. 2006

Australas. Phys. Eng. Sci. Med.

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In order to simulate the hemodynamic environment of human arteries in vivo, we designed a laminar flow apparatus which can precisely simulate the normal stress and shear stress to which cultured endothelial cells are exposed. Under both normal and abnormal physiological conditions, this apparatus can accurately control and adjust the values of normal stress and shear stress and the frequency of pulse waves, as well as the amplitude of pulsatile flow. This in vitro apparatus provides an experimental platform for studying the response of the biological characteristics of cultured endothelial cells in a hemodynamic environment.

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Design of compliance chamber and after-load in apparatus for cultured endothelial cells subjected to stresses

Ding

Qiao

Shen

et al. 2006

Cell Biology International

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In order to create a hemodynamic environment that can simulate the physiological condition of arteries, an in vitro experiment apparatus was designed whose key modules were compliance chamber and after-load. These two modules were developed based on the theories of hemodynamics. Both the normal and shear stress to which endothelial cells are exposed can be controlled with these modules, thus facilitating the research of endothelial cells subjected to stresses.

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Determination of arterial wall shear stress

Cited by 6 publications

References 4 publications

A multiscale model for analyzing the synergy of CS and WSS on the endothelium in straight arteries

A multiscale model for analyzing the synergy of CS and WSS on the endothelium in straight arteries

An apparatus for studying the response of cultured

Design of compliance chamber and after-load in apparatus for cultured endothelial cells subjected to stresses

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