Determination of anticancer activity and biosynthesis of Cu, Zn, and Co hybrid nanoflowers with Tribulus terrestris L. extract

Yilmaz, Burcu Somturk; Bekci, Hatice; Altiparmak, Aysegul; Uysal, Sengul; Şenkardeş, İsmail; Zengin, Gökhan

doi:10.1016/j.procbio.2024.01.011

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…In addition, O–H / N–H, C–O, and C–C stretching originating from the extract were observed. ZnNFs show similarity with the ZPO FTIR spectrum [ 30 , 31 ]. The bands mentioned in the extract were not observed in ZnNFs.…”

Section: Resultsmentioning

confidence: 99%

Plant-based zinc nanoflowers assisted molecularly imprinted polymer for the design of an electrochemical sensor for selective determination of abrocitinib

Cetinkaya,

Yusufbeyoglu,

Kaya

et al. 2024

Microchim Acta

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The first electrochemical sensor application in the literature is described for the sensitive and selective determination of the selective Janus kinase (JAK)-1 inhibitor abrocitinib (ABR). ABR is approved by the U.S. Food and Drug Administration (FDA) for the treatment of atopic dermatitis. The molecularly imprinted polymer (MIP)-based sensor was designed to incorporate zinc nanoflower (ZnNFs)-graphene oxide (GO) conjugate (ZnNFs@GO), synthesized from the root methanolic extract (RME) of the species Alkanna cappadocica Boiss. et Bal. to improve the porosity and effective surface area of the glassy carbon electrode (GCE). Furthermore, the MIP structure was prepared using ABR as a template molecule, 4-aminobenzoic acid (4-ABA) as a functional monomer, and other additional components. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) were used to characterize the surface and structure of the synthesized nanomaterial and MIP-based surface. Among the electrochemical methods, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were preferred for detailed electrochemical characterization, and differential pulse voltammetry (DPV) was preferred for all other electrochemical measurements using 5.0 mM [Fe(CN)6]3–/4– solution as the redox probe. The MIP-based sensor, which was the result of a detailed optimization phase, gave a linear response in the 1.0 × 10–13 – 1.0 × 10–12 M range in standard solution and serum sample. The obtained limit of detection (LOD) and limit of quantification (LOQ) values and recovery studies demonstrated the sensitivity, accuracy, and applicability of the sensor. Selectivity, the most important feature of the MIP-based sensor, was verified by imprinting factor calculations using ibrutinib, ruxolitinib, tofacitinib, zonisamide, and acetazolamide. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Plant-based zinc nanoflowers assisted molecularly imprinted polymer for the design of an electrochemical sensor for selective determination of abrocitinib

Cetinkaya,

Yusufbeyoglu,

Kaya

et al. 2024

Microchim Acta

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Antimicrobial and Anticancer Activity of Gallic Acid–Cu(II) Hybrid Nanoflowers and Gallic Acid–Zn(II) Hybrid Nanoflowers

Somtürk Yilmaz

2024

J Inorg Organomet Polym

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Herein, synthesis and characterization of hybrid nanoflowers (hNFs) using gallic acid as organic components, and Cu(II), and Zn(II) ions which were involved as the inorganic component was carried out. In the first part of the study, the morphologies of the synthesized hNFs were investigated using SEM, EDX, XRD, FT-IR, and mapping. In the second part of the study, the antimicrobial activities of the synthesized hNFs were examined. Antimicrobial activities of hNFs were systematically studied against Staphylococcus aureus, Escherichia coli, P. aeruginosa, and Candida albicans with broth microdilution and short time-kill assay. In addition, the anticancer activity of hNFs was examined. For this, A549 and MCF7 cell lines were used. Graphical Abstract

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Synthesis, Characterization, Cytotoxic Activity Studies of N1-phenylbenzene-1,2-diamine @CuhNFs and 1,2-phenylenediamine@CuhNFs, and Molecular Docking Calculations of Their Ligands

Somturk-Yilmaz,

Turkmenoglu,

Akkoc

2024

J Inorg Organomet Polym

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In recent years, hybrid nanoflowers (hNFs), the newest class of nanoparticles, have been highly preferred due to their excellent activity and stability. In this study, hybrid nanoflower synthesis was carried out using N1-phenylbenzene-1,2-diamine and 1,2-phenylenediamine as the organic part and copper(II) metal ions as the inorganic part. In the first stage, the characterization of the synthesized hybrid nanoflowers was carried out using various techniques. For the characterization of the synthesized hNFs, structure elucidation was performed using Scanning Electron Microscopy (SEM), Energy Dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD) spectroscopy and elemental mapping. In the other study stage, the cytotoxic effects of hybrid nanoflowers were evaluated using A549 and MCF7 cell lines. When 1,2-phenylenediamine and N1-phenylbenzene-1,2-diamine were converted into CuhNFs, it was effective in MCF7 and A549 cell lines. Docking studies were performed using the Prime MM-GBSA method to estimate binding affinities and determine the binding mode. ADME analysis was performed using the Schrödinger 2021-2 QikProp wizard. Support was obtained from molecular docking to confirm the potential of N1-phenylbenzene-1,2-diamine and 1,2-phenylenediamine compounds for both breast and lung cancer. Molecular docking studies can provide information about binding interactions between compounds with identified targets, which may explain their inhibitory activity. A better result can be obtained by examining the binding patterns in the active binding region of the compounds through molecular docking.Graphical Abstract

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Determination of anticancer activity and biosynthesis of Cu, Zn, and Co hybrid nanoflowers with Tribulus terrestris L. extract

Cited by 4 publications

References 47 publications

Plant-based zinc nanoflowers assisted molecularly imprinted polymer for the design of an electrochemical sensor for selective determination of abrocitinib

Plant-based zinc nanoflowers assisted molecularly imprinted polymer for the design of an electrochemical sensor for selective determination of abrocitinib

Antimicrobial and Anticancer Activity of Gallic Acid–Cu(II) Hybrid Nanoflowers and Gallic Acid–Zn(II) Hybrid Nanoflowers

Synthesis, Characterization, Cytotoxic Activity Studies of N1-phenylbenzene-1,2-diamine @CuhNFs and 1,2-phenylenediamine@CuhNFs, and Molecular Docking Calculations of Their Ligands

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