“…QuEChERS is a quick, easy, cheap, effective, robust, and safe extraction compared to the above methods, which may present some difficulties related to time consumption and labor intensity, the low recovery of some target compounds, poor reproducibility, and method improvement [20]. Various modifications of QuEChERS extraction have been reported in the literature for the analysis of pharmaceutical drug residues in milk, using different sorbents for the clean-up step or a combination of them, e.g., octadecylsilane, (C18) as the usual sorbent to improve extraction on high-fat food matrices, primary secondary amine (PSA), and sodium acetate (NaOAc) [6,16,21,22]. Moreover, the Enhanced Matrix Removal-Lipid (EMR-Lipid) is a new product used as a dispersive SPE (dSPE), promising the highly selective removal of lipids, without the retention of the analyte.…”