Determination of antibacterial quaternary ammonium compounds in lozenges by capillary electrophoresis

Taylor, Robert B.; Toasaksiri, S; Reid, R.G.

doi:10.1016/s0021-9673(97)00986-2

Cited by 40 publications

(37 citation statements)

References 27 publications

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“…Quaternary ammonium salts are positively charged polyatomic ions of symmetrical R4N + Br -structure [10] which has been used numerously in phase transfer catalysis [11][12][13], and as antimicrobial agents in many disinfectants, perfumes and cosmetics [14,15]. Cetyltrimethyl ammonium bromide (CTABr) micellization in aqueous solution occurs as a result of delicate balance between the favourable hydrophobic interaction between the alkyl chains and opposing repulsive interaction between the ionic head group [6,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Conductometric Studies on the Effect of Temperature and Tetramethylammonium Bromide Salt on the Micellization of Cetyltrimethylammonium Bromide in Aqueous Medium

Esan

Olubunmi²,

Olumuyiwa³

et al. 2015

Int. J. Thermo

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Section: Introductionmentioning

confidence: 99%

Conductometric Studies on the Effect of Temperature and Tetramethylammonium Bromide Salt on the Micellization of Cetyltrimethylammonium Bromide in Aqueous Medium

Esan

Olubunmi²,

Olumuyiwa³

et al. 2015

Int. J. Thermo

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“…More recently, capillary electrophoresis (CE) has been employed for the analysis of cationic surfactants. [18][19][20] In this paper, we present a flotation-spectrophotometric method for quantitative determination of Cetylpyridinium chloride (CPC), based on its ion associate formation with OR and then the extraction of CPC + -OR -ion-pair into the interface between aqueous and n-hexane phase by flotation method. The method proposed has been successfully applied to the determination of cetylpyridinium chloride in pharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

Development of a flotation-spectrophotometric method for determination of cetylpyridinium chloride in pharmaceutical products

Parham¹,

Moradi²

2011

Quím. Nova

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Recebido em 17/8/10; aceito em 16/11/10; publicado na web em 18/2/11A new simple and sensitive flotation-spectrophotometric method for the determination of cetylpyridinium chloride (CPC) is reported. The method is based on the formation of an ion-associate between CPC and Orange II (OR) which is floated in the interface of aqueous phase and n-hexane by vigorous shaking. The aqueous solution was discarded and the adsorbed ion associate on to the wall of a separating funnel was dissolved in a small volume of methanol solvent and its absorbance was measured at 480 nm. The apparent molar absorptivity (ε) of the ion associate was determined to be 4.12 x 10 5 L mol -1 cm -1 . The calibration graph was linear in the concentration range of 15-800 ng mL -1 of CPC with a correlation coefficient of 0.9988. The limit of detection (LOD) was 10.8 ng mL -1 . The relative standard deviation (RSD) for determination of 100 and 800 ng mL -1 of CPC was 3.47 and 2.04% (n=7), respectively. The method was successfully applied to the determination of CPC in a commercial mouth washer product.

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“…The usual methods for the determination of cationic surfactants are ion-association titration, 12 extraction spectrometry, 13 high performance liquid chromatography with reversed 14,15 and ion-pair normal phase, 16 and also capillary zone electrophoresis (CZE). [17][18][19][20][21][22][23][24] The application of capillary isotachophoresis for the separation of C8-C20 cationic surfactants has been already reported by Tribet et al 25,26 and Praus. 27 The aim of this work was to study the CSs adsorption on montmorillonite.…”

Section: Introductionmentioning

confidence: 99%

A physico-chemical study of the cationic surfactants adsorption on montmorillonite

Praus¹,

Turicová²

2007

J. Braz. Chem. Soc.

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O objetivo deste trabalho é o estudo da adsorção de brometo de cetiltilmetilamônio (CTA) e de cloreto de cetilpiridínio (CP) em argilas do tipo montorilonita (MMT) ricas em sódio. Um método isotacoforético (ITP) específico foi desenvolvido visando à determinação rápida e simultânea dos surfatantes catiônicos (CS) adsorvidos. A fim de reduzir os limites de detecção, o método isotacoforético foi conjugado com a técnica de eletroforese capilar. Para determinar o arranjo dos surfatantes catiônicos (CS) adsorvidos na superfície das argilas foi efetuada a avaliação do balanço molar entre os surfatantes e os cátions metálicos juntamente com as isotermas de adsorção. A maior adsorção do CP comparada a do CTA pode ser entendida não só pela ação das forças eletrostáticas, mas também por outras interações, tais como, interação hidrofóbica cauda-cauda e/ou interações entre anéis piridínicos formando bicamadas incompletas e/ou monocamadas condensadas, respectivamente.The adsorption of cetyltrimethylammonium (CTA) bromide and cetylpyridinium (CP) chloride on Na + -rich montmorillonite (MMT) was studied. An ad hoc isotachophoretic (ITP) method was developed for the simultaneous and rapid determination of the cationic surfactants (CSs) adsorbed. In order to decrease the detection limits, ITP was on-line coupled with capillary zone electrophoresis. Adsorption data were analysed by their fitting with adsorption isotherms. The adsorption of CP is well described by the Langmuir isotherm. It indicates the monolayer arrangement of CP on the MMT surface. In case of the CTA data, the best fitting LangmuirFreundlich model with the power constant r<1 was found. It can be explained by the CTA interactions because of its intercalation into the MMT interlayer space.

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Determination of antibacterial quaternary ammonium compounds in lozenges by capillary electrophoresis

Cited by 40 publications

References 27 publications

Conductometric Studies on the Effect of Temperature and Tetramethylammonium Bromide Salt on the Micellization of Cetyltrimethylammonium Bromide in Aqueous Medium

Conductometric Studies on the Effect of Temperature and Tetramethylammonium Bromide Salt on the Micellization of Cetyltrimethylammonium Bromide in Aqueous Medium

Development of a flotation-spectrophotometric method for determination of cetylpyridinium chloride in pharmaceutical products

A physico-chemical study of the cationic surfactants adsorption on montmorillonite

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