Determination of Antialdosterone Activity in Normal Dogs

Rosenthale, Marvin E.; Schneider, Fred; Kassarich, Jacob; Datko, Louis J.

doi:10.3181/00379727-118-29977

Cited by 8 publications

(12 citation statements)

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“…Several immunosuppressive agents such as cyclophosphamide (10)(11)(12)(13)(14), cyclosporine A (15, 16), azathioprine (12), corticosteroids (17-21), and total lymphoid irradiation (22) have been used. However, suppression ofthe disease by such treatments requires chronic administration of the cytoreductive drug (13), which usually results in cumulative toxic side effects; moreover, discontinuation of therapy is often associated with reappearance of paralytic signs (12,23). Treatment of ongoing CR-EAE with apparent paralytic signs and histological evidence of brain damage was shown to be more diffitcult (13).…”

mentioning

confidence: 99%

Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide).

Karussis

Lehmann²,

Slavin³

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

107

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mentioning

confidence: 99%

Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide).

Karussis

Lehmann²,

Slavin³

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

107

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“…Cyclophosphamide (CY) was shown to be a very effective agent for inhibition ofactively and passively induced acute EAE (16)(17)(18)(19)(20)(21)(22). However, treatment ofCR-EAE requires chronic administration of the cytoreductive drug, and the cessation of treatment is often associated with reappearance of paralytic signs and a severe neurological outcome (19,20,22). Moreover, the chronic treatment is accompanied with acumulative toxic side effects.…”

Section: Introductionmentioning

confidence: 99%

Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation.

Karussis¹,

Vourka-Karussis²,

Lehmann³

et al. 1993

J. Clin. Invest.

117

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IntroductionA chronic relapsing form ofexperimental autoimmune encephalomyelitis (CR-EAE) was induced in SJL/J mice by adoptive transfer of lymph node cells (LNC) sensitized to guinea pig myelin basic protein (GMBP). We examined the efficacy of high dose immunosuppressive regimens (cyclophosphamide ICY] 300 mg/kg or total body irradiation ITBI1 900 cGy) followed by syngeneic bone marrow transplantation (SBMT) in prevention and treatment of already established CR-EAE. Treatment with TBI and SBMT on day 5 after the induction of CR-EAE, just before the onset of clinical signs, completely inhibited the appearance of the paralytic signs. The same treatment, applied 4 d after the clinical onset of the disease, led to a significant regression of the paralytic signs and to a total inhibition of spontaneous relapses during a follow-up period of 2 mo. Challenge of mice with GMBP+CFA 78 d after the passive induction of CR-EAE induced a relapse of the disease 7 d later in almost all of the untreated mice; in contrast, the same challenge given to TBI+SBMT-treated mice caused a delayed relapse (30 d later) in only a minority (3/7) of the challenged mice. In vitro lymphocytic proliferative responses to GMBP and purified protein derivative were significantly lower in TBI+SBMT-treated mice before and after the GMBP challenge, although these mice were fully immunocompetent, as evidenced by their normal lymphocytic proliferation to concanavalin A (ConA) and the FACS® analysis of their lymphocytic subpopulations. A similar beneficial therapeutic effect was observed in mice treated with CY followed by SBMT, after the onset of CR-EAE.

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“…Experimental allergic encephalomyelitis (EAE) is a model of delayed hypersensitivity which has been useful in evaluating various anti-immune compounds [9]. At 15 daily oral doses, oxaprozin at 300 mg/kg, indomethacin at 6 mg/kg (6 of 12 rats died), phenylbutazone at 250 mg/kg and aspirin at 250 mg/kg (1 of 12 rats died) were all inactive in this model.…”

Section: (4) Effect On Immune Mechanismsmentioning

confidence: 99%

“…EAE was induced in male Lewis strain rats (185-210 g) by the subplantar injection into the right hind paw of 0.05 ml of an encephalitogenic emulsion [9].…”

Section: Experimental Allergic Encephalomyelitis (Eae)mentioning

confidence: 99%

Anti-inflammatory properties of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin)

Rosenthale¹,

Begany²,

Dervinis³

et al. 1974

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The uxazole, oxaprozin has a spectrum of activity in various in vivo and in vitro, chronic and acute inflammatory models in 3 species indicating that it belongs to the general class of non-steruidal anti-inflammatory agents. Possible advantageous features of oxaprozin over existing nonsteroidal anti-inflammatory agents include relative safety, minimal irritant properties on the gastrointestinal tract, long half-life, and urieosurie properties.

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Determination of Antialdosterone Activity in Normal Dogs

Cited by 8 publications

References 0 publications

Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide).

Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide).

Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation.

Anti-inflammatory properties of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin)

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