Determination of antazoline hydrochloride in Beagle dog plasma by HPLC–UV and its application to pharmacokinetics

Determination of the neuropharmacological drug nodakenin in rat plasma and brain tissues by liquid chromatography tandem mass spectrometry: Application to pharmacokinetic studies

“…Several analytical methods have been established for determination of nodakenin in plants and herbal prescriptions, including high‐performance liquid chromatography (HPLC) with photodiode array detection (Seo, Kim, & Shin, ; Seo et al, ; Yoon et al, ), HPLC‐diode array detector coupled with mass spectrometry (Ahn et al, ; Kim, Yang, et al, ; Liu, Li, Song, & Wei, ; Xu et al, ), HPLC tandem mass spectrometry (HPLC–MS/MS; Shen, Han, Huang, Zhu, & Lei, ; Cheng et al, ) and ultra‐performance liquid chromatography–electrospray ionization tandem mass spectrometry (UPLC‐ESI‐MS/MS; Lee, Shon, & Yoon, ). Moreover, we also noticed that some HPLC methods have been described for the pharmacokinetic study of nodakenin in rat and dog plasma, such as UV detection (Liu & Li, ; Zhang, Li, & Yang, ; Zhang & Yang, ) and fluorescence detection (Li & Sun, ). However, all these methods have some drawbacks such as poor selectivity, low sensitivity or long analysis times that do not meet the requirements for biosample analysis.…”

Cloud-point extraction is compatible with liquid chromatography coupled to electrospray ionization mass spectrometry for the determination of antazoline in human plasma

“…However, to make the entire method more environmentally-friendly ethanol should also be used as the HPLC solvent. 7 …”

“…There are only three publications describing antazoline extraction from biological material [6,7,8]. All of these are preceded by liquid-liquid extraction (LLE) with the use of ethyl acetate as the solvent.…”

Self-assembled benzyl mercaptan monolayer as a coating in electromembrane surrounded solid-phase microextraction of antihistamines in urine and plasma samples

“…In addition, the type of solvent can affect the diffusion coefficient of the analyte 28 and it could be adjusted to increase the selectivity and sample cleanup. 29,30 Based on the previously published results, NPOE is an efficient organic solvent for extraction of basic drugs. 31 Also, addition of some carriers to NPOE could improve phase transfer and electrokinetic migration of the basic analytes.…”