Determination of angiotensin-converting enzyme concentration in cardiovascular patients

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives each year, More than four out of five CVD deaths are due to heart attacks and strokes, and one third of these deaths occur prematurely in people under 70 years of age . The circulating Renin Angiotensin Aldosterone system (RAAS) comprises liver - secreted angiotensinogen (AGT) that is enzymatically converted into angiotensin I (Ang I). ACE, as a key component in RAS, converts angiotensin I to angiotensin II, Angiotensin II increase the production of adhesion molecules and chemokines stimulates LDL oxidation and foam cell formation in macrophages, Increased level of the ACE and subsequent ACE activity by raising the production of angiotensin II can lead to atherosclerosis . A number of 100 subjects were involved in this investigation, 100 patients of CVDs in AL-Saddir Hospital and AL Hkem Hospital, in AL- Najaf province, 70 of them with CVDs and the other 30 healthy individuals, were used as control.The study was conducted to find out the importance of Determination of angiotensin-converting enzyme concentration in cardiovascular patients and some clinical and biochemical variables .