Abstract:Nuclear and cytosolic androgen receptor concentrations in tissues of human benign prostatic hypertrophy (BPH) were determined by use of methyltrienolone (R-1881) and 7Α,17Α-dimethyl-19-nortestosterone (DMNT) as radiolabeled ligands. Cytosolic R-1881-binding sites were 46.1 ± 43 fmol/mg protein and nuclear R-1881-binding sites were 51.8 ± 42 fmol/mg protein. DMNT-binding sites in cytosol were 44.3 ± 38 fmol/mg protein and in nuclear extract 73.4 ± 64 fmol/mg protein. No significant correlation was found between… Show more
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