Determination of an Aspergillus fumigatus-Specific Immunoglobulin G Reference Range in an Adult Omani Population

Al-Rahman, Munira; Kindi, Mahmood Al; Kutty, Ibrahim; Al-Kalbani, Ibrahim; Alshekaili, Jalila

doi:10.18295/squmj.2018.18.01.007

Cited by 1 publication

(9 citation statements)

References 15 publications

(21 reference statements)

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“…Moreover, many previous studies confirmed A. fumigatus as the main causal pathogen (Page et al, 2016(Page et al, , 2018Al-Rahman et al, 2018;Sehgal et al, 2018;Lee et al, 2020). A previous study found that A. niger was the most frequently isolated Aspergillus spp.…”

Section: Discussionmentioning

confidence: 84%

“…exists in a wide range of environments. A substantial number of species are pathogens that are responsible for a collective group of clinical diseases referred to as aspergillosis ( Al-Rahman et al, 2018 ). Among them, Aspergillus fumigatus is the main cause of disease, accounting for approximately 80% of aspergillosis ( Al-Rahman et al, 2018 ; Jat et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…A substantial number of species are pathogens that are responsible for a collective group of clinical diseases referred to as aspergillosis ( Al-Rahman et al, 2018 ). Among them, Aspergillus fumigatus is the main cause of disease, accounting for approximately 80% of aspergillosis ( Al-Rahman et al, 2018 ; Jat et al, 2018 ). Other species of Aspergillus , such as Aspergillus niger, Aspergillus flavus , and Aspergillus terreus are less frequently reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…Aspergillosis is classified into three types, allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), and invasive aspergillosis (IA), according to host immunity ( De Pauw et al, 2008 ; Agarwal et al, 2013a ; Denning et al, 2016 ; Al-Rahman et al, 2018 ; Jat et al, 2018 ; Sehgal et al, 2018 ). Most patients with aspergillosis present with respiratory symptoms, such as cough, wheezing, chest pain, dyspnea, fever, weight loss, and hemoptysis.…”

Section: Introductionmentioning

confidence: 99%

“…Allergic bronchopulmonary aspergillosis is an allergic inflammatory disease resulting from exposures to Aspergillus spp. that is commonly seen in patients with asthma and cystic fibrosis ( Watkins et al, 2012 ; Agarwal et al, 2013a , b , 2015 , 2017 ; Douglass et al, 2014 ; Shah and Panjabi, 2016 ; Al-Rahman et al, 2018 ; Jat et al, 2018 ). ABPA has been estimated to affect 4 million people globally ( Agarwal et al, 2013a , b , 2014 , 2017 ; Douglass et al, 2014 ; Shah and Panjabi, 2016 ; Jat et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Aspergillus-specific antibody cut-offs for the diagnosis of aspergillosis

Hsiao

Yen

et al. 2022

Front. Microbiol.

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BackgroundAspergillus diseases are frequently encountered in patients who are immunocompromised. Without a prompt diagnosis, the clinical consequences may be lethal. Aspergillus-specific antibodies have been widely used to facilitate the diagnosis of Aspergillus diseases. To date, universally standardized cut-off values have not been established. This study aimed to investigate the cut-off values of Aspergillus-specific antibodies and perform a narrative review to depict the geographic differences in the Taiwanese population.MethodsWe analyzed enrolled 118 healthy controls, 29 patients with invasive aspergillosis (IA), chronic pulmonary aspergillosis (CPA), and allergic bronchopulmonary aspergillosis (ABPA) and 99 with disease control, who were tested for Aspergillus fumigatus and Aspergillus niger-specific IgG and IgE using ImmunoCAP. 99 participants not fulfilling the diagnosis of IA, CPA, and ABPA were enrolled in the disease control group. The duration of retrieval of medical records from June 2018 to September 2021. Optimal cut-offs and association were determined using receiver operating characteristic curve (ROC) analysis.ResultsWe found that patients with CPA had the highest A. fumigatus-specific IgG levels while patients with ABPA had the highest A. fumigatus-specific IgE, and A. niger-specific IgG and IgE levels. In patients with CPA and ABPA, the optimal cut-offs of A. fumigatus-specific IgG and A. niger-specific IgG levels were 41.6, 40.8, 38.1, and 69.9 mgA/l, respectively. Geographic differences in the cut-off values of A. fumigatus-specific IgG were also noted. Specifically, the levels were different in eco-climatic zones.ConclusionWe identified the optimal cut-offs of Aspergillus-specific antibodies to facilitate a precise diagnosis of aspergillosis. The observed geographic differences of the antibody levels suggest that an eco-climatic-specific reference is needed to facilitate a prompt and accurate diagnosis of aspergillosis.

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