Determination of ambroxol in dog plasma by high-performance liquid chromatography and UV detection

Kiss, Borbála Dalmadi; Nemes, Katalin; Ürmös, I.; Szúnyog, József; Klebovich, Imre

doi:10.1007/bf02492809

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B Instrumental Detection Modes1

B Metabolic Studies1

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2003

2022

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Cited by 7 publications

(2 citation statements)

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“…Digital autoradiography (DAR) offers higher sensitivity than contact autoradiography, which makes possible significant reductions in the time needed to detect radiolabeled compounds and/or reduction in the quantity of analyte (145), as shown for metabolite products in dog urine samples. Implementation of OPLC separation improved the performance of the method (146)(147)(148). Klebovich (95) reviewed the applications of DAR in planar chromatography.…”

Section: B Instrumental Detection Modesmentioning

confidence: 98%

Pharmaceuticals and Drugs

Nyiredy¹,

V√©gh²,

Szepesi³

et al. 2003

Handbook of Thin-Layer Chromatography

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Section: B Instrumental Detection Modesmentioning

confidence: 98%

Pharmaceuticals and Drugs

Nyiredy¹,

V√©gh²,

Szepesi³

et al. 2003

Handbook of Thin-Layer Chromatography

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“…OPLC-DAR, a new hyphenated technique, has numerous advantages over TLC-DAR in metabolic research (11,61,62). After optimization, normal-and reversed-phase HPTLC plates are equally suitable for OPLC separation and DAR detection of minor and major radioactive metabolites of different polarities.…”

Section: B Metabolic Studiesmentioning

confidence: 99%

Thin-Layer Radiochromatography

Klebovich¹,

Hazai²

2003

Handbook of Thin-Layer Chromatography

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Voltammetric Oxidation of Ambroxol and Application to Its Determination in Pharmaceuticals and in Drug Dissolution Studies

et al. 2003

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A detailed study of the electrochemistry of ambroxol at a glassy carbon electrode was carried out in the pH range 1.8 ± 11.0 in aqueous solution using cyclic and differential pulse voltammetry. The compound was oxidized irreversibly at high positive potentials resulting in the formation of a chemical product at less positive potentials, which was more readily oxidized than the parent compound. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations, and in drug dissolution studies.

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Determination of ambroxol in dog plasma by high-performance liquid chromatography and UV detection

Cited by 7 publications

References 7 publications

Pharmaceuticals and Drugs

Pharmaceuticals and Drugs

Thin-Layer Radiochromatography

Voltammetric Oxidation of Ambroxol and Application to Its Determination in Pharmaceuticals and in Drug Dissolution Studies

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