Determination of aldehydes in exhaled breath of patients with lung cancer by means of on-fiber-derivatisation SPME–GC/MS

Urinary Volatile Compounds as Biomarkers for Lung Cancer

“…Phillips et al reported that comparing exhaled breath of lung cancer patients and healthy subjects, branched hydrocarbons and alkanes were more abundunt in the lung cancer patients. 21) Deng et al also reported using volatile biomarkers in the blood of patients with lung cancer. 20) In the present study, we focused on VOCs obtained through the urine of lung cancer patients.…”

“…14,15,[20][21][22][23][24][25][26][27][28][29][30][31][32] Most of these biomarkers are alkanes, alkane, and benzene derivatives. Phillips et al reported that comparing exhaled breath of lung cancer patients and healthy subjects, branched hydrocarbons and alkanes were more abundunt in the lung cancer patients.…”

Comparison of Medical and Forensic Profiling Potential of Volatile Biomarkers from Different Biological Specimens from Individuals and Across Populations

“…Common names for some of the compounds are given in parentheses and italicized. Many of the presented compounds have been previously reported to be volatile emanation compounds of human skin 5,14,28,29,123 , saliva 127 , breath 44,48,97,128 , volatile constituents of human blood 18,62,66,67 , and urine [70][71][72] . Compounds denoted by "en" are possibly endogenous compounds, while compounds denoted by "ex" are possibly of exogenous origin.…”

A microreactor approach for chemoselective capture and analysis of carbonyl compounds in air and exhaled breath.

“…Carbonyl compound concentrations in ambient air of urban and rural areas and in emission gases form vehicles have been widely measured (Grosjean and Fung, 1982;Kuwata et al, 1983;Levin et al, 1985;Uchiyama et al, 2003;Uebori and Imamura, 2004) In recent years, several investigators have suggested that certain ketones and aldehydes in exhaled breath could be used as metabolic markers of lung cancer for 29 noninvasive diagnosis of lung cancer in its early stages (Phillips et al, 2008;Bajtarevic et al, 2009;Fuchs et al, 2010;Poli et al, 2010) and chronic obstructive pulmonary disease (COPD) (Corradi et al, 2003). The reported concentrations of these ketones and aldehydes in breath are in the ppbv to pptv range.…”

“…hydroxylamine hydrochloride (PFBHA) Poli et al, 2010) and 2, 4-dinitrophenylhydrazine (DNPH) (Grosjean et al, 2002;Fusaya et al, 2004;Wang et al, 2007) as sampling media has been used for analysis of aldehydes in exhaled breath. SPME is a popular preconcentration method introduced two decades ago as a rapid extraction technique for analysis of volatile organic compounds from a variety of matrixes (Arthur and Pawliszyn 1990).…”