Determination of aflatoxins B1 and B2 using ion mobility spectrometry

Sheibani, Ali; Tabrizchi, Mahmoud; Ghaziaskar, Hassan S.

doi:10.1016/j.talanta.2007.11.006

Cited by 40 publications

(41 citation statements)

References 26 publications

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“…IMS is not able to resolve two ions with similar structure that differ by only 2 amu. This was the case in our previous 18 .…”

Section: Optimization Of the Ims Operation Parameterssupporting

confidence: 68%

“…17 . The newly designed injection port 18 for direct introducing liquid samples into the IMS was used. The injection port was filled with steel wool to enhance evaporation rate of the solvent and analyte.…”

Section: Instrumentationmentioning

confidence: 99%

“…The number of ions reach to the detector is considered as a measure of the analytes concentration. IMS has applied for the rapid and sensitive detection of trace amounts of a broad range of compounds [17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

“…We previously, reported the capability of IMS equipped with positive corona discharge ionization source in determination of AFB 1 and AFB 2 in pistachio nut as a real sample 18 . Here, the method was extended for the determination of AFG 1 and AFG 2 and also the simultaneous determination of AFB and AFG in pistachio sample investigated.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Aflatoxins G and GUsing Ion Mobility Spectrometry

Sheibani¹,

Zare-Khormizi²,

Tabrizchi³

2012

Orientjchem.

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This work describes a rapid and sensitive ion mobility spectrometry method for the determination of aflatoxins G 1 and G 2 (AFG 1 and AFG 2 ). The effective instrumental parameters were investigated and optimized. After optimizing, the calibration curves for AFG 1 and AFG 2 were linear in the range of 1 to 300 ng. Relative standard deviation was 8% and limit of detection was 0.5 ng. The capability of the proposed method was evaluated for the determination of AFG in spiked pistachio nut as a real sample that satisfactory results were obtained.Key words: Aflatoxin G (AFG), Aflatoxin B (AFB), Ion mobility spectrometry (IMS), Pistachio nut.Some reports indicate natural contamination with AFB and AFG mainly in countries with warm and humid climate [6][7][8] .

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“…IMS is not able to resolve two ions with similar structure that differ by only 2 amu. This was the case in our previous 18 .…”

Section: Optimization Of the Ims Operation Parameterssupporting

confidence: 68%

Section: Instrumentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of Aflatoxins G and GUsing Ion Mobility Spectrometry

Sheibani¹,

Zare-Khormizi²,

Tabrizchi³

2012

Orientjchem.

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“…However, as known from the literature, corona discharge ionization can be used for ionization of a broad range of different classes of chemical compounds. [39][40][41][42][43] In this study, we determined the detection limit and reproducibility of the new IMS equipped with corona discharge ionization source using cocaine. The sample was injected with liquid solution to compare the results of APCI-MS. An illustration of the basic ionization process of cocaine in the IMS is presented in Figure 1.…”

mentioning

confidence: 99%

Comparison of Cocaine Detections in Corona Discharge Ionization-Ion Mobility Spectrometry and in Atmospheric Pressure Chemical Ionization-Mass Spectrometry

Choi¹,

Kim²,

Kim³

et al. 2010

Bulletin of the Korean Chemical Society

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Ion mobility spectrometry (IMS) was a technique originally applied for the detection of trace compounds. 1-3 IMS has been widely used to detect chemical warfare agents, 4-6 explosives, [7][8][9][10] and illegal drugs 10-13 since it combines both high sensitivity (detection limits down to the ng/L range to pg/L range, ppb range and ppt range) and relatively low technical expenditure with high-speed data acquisition. The time required to acquire a single spectrum is in the range of several tens ms. The working principle is based on the drift of ions at ambient pressure under the influence of an external electric field. 14-20 IMS works in a similar way to a time-of-flight mass spectrometer (TOFMS). The major difference is that TOFMS requires a vacuum but IMS does not. The mean free path of the ions in IMS is very smaller than in TOFMS. A typical IMS is comprised of an ionization source associated with an ion reaction chamber, an ion drift tube, an ion/molecule injection shutter placed between the ion reaction chamber and the ion drift tube, and an ion collector (detector, Faraday plate). An ion swarm drifting under the electric field experiences a separation process based on ions with different masses or structures having different drift velocities. Collecting these ions on a Faraday plate delivers a time-dependent signal corresponding to the mobility of the arriving ions. This ion mobility spectrum contains information on the nature of the different trace compounds present in the sample gas.Mass spectrometry is an important tool for the structural analysis of unknown chemicals. Soft ionization techniques such as matrix-assisted laser desorption and ionization (MALDI) and atmospheric pressure ionization (API) have been used for determination of molecular weight of an analyte. [21][22][23][24][25][26][27][28][29][30][31][32][33][34] Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are the most currently used as API sources. In APCI, a corona discharge makes solvent reactant ions that are used to ionize the analyte by chemical ionization. [31][32][33][34] Solvent and analyte are vaporized by pneumatic nebulization. APCI relies upon gas-phase ion-molecule reactions to place a charge on neutral analytes, so it is especially important to understand these reactions. The solvent-derived ions serve as reagents for proton transfer ionization.Cocaine is a powerfully addictive drug because of its instantaneous and overwhelming effects on the central nervous system. It is generally analyzed by gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), GC, or LC. Recently, it has been analyzed using IMS. 11,[35][36][37] Lu and coworkers 35 analyzed cocaine and its metabolites, benzoylecgonine and cocaethylene in urine using solid phase extraction (SPE) coupled with IMS, and reported that the detection limits of benzoylecgonine and cocaethylene are 10 ng/mL (10 ppb) and 4 ng/mL (40 ppb), respectively. Dussy and coworkers 36 examined the validation of a qualita...

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Resolution enhancement of overlapped peaks of ion mobility spectrometry based on stationary wavelet transform

Sheibani

Saeedi-Sourck

Tabrizchi

2017

Journal of Chemometrics

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Lack of sufficient resolving power is one common problem in quantitative determination using ion mobility spectrometry (IMS) method. This paper proposes a new application of stationary wavelet transform (SWT) in resolving the overlapped peaks in IMS. Firstly, the ion product overlapped peaks are denoised by wavelet transform and secondly, the overlapping peaks are resolved by looking into coefficients of SWT. One-and two-component overlapping ion peaks of IMS are processed with the developed SWT method, which yields the significant improvement of resolution.KEYWORDS denoising, ion mobility spectrometry (IMS), overlapping peaks, resolution enhancement, stationary wavelet transform (SWT)

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Determination of aflatoxins B1 and B2 using ion mobility spectrometry

Cited by 40 publications

References 26 publications

Determination of Aflatoxins G and GUsing Ion Mobility Spectrometry

Determination of Aflatoxins G and GUsing Ion Mobility Spectrometry

Comparison of Cocaine Detections in Corona Discharge Ionization-Ion Mobility Spectrometry and in Atmospheric Pressure Chemical Ionization-Mass Spectrometry

Resolution enhancement of overlapped peaks of ion mobility spectrometry based on stationary wavelet transform

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