Determination of absolute configuration by 31P NMR

Szyszkowiak, Jagoda; Majewska, Paulina

doi:10.1016/j.tetasy.2013.12.011

Cited by 10 publications

(1 citation statement)

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“…31 P-NMR spectroscopy is highly useful, since compounds from natural resources normally contain this nucleus and 31 P is more abundant (100%), making it a valuable probe for NMR investigations [ 48 ]. Recently, Szyszkowiak and Majewska have reviewed the application of 31 P-NMR for determination of the absolute configuration of organic compounds [ 49 ]. In this review, the model created by Hammersschmidt and Li, in which the shielding of the phosphorus atom by the phenyl group in ( S )-MTPA ester caused the signal to appear at a higher field ( Scheme 11 ), was explored [ 50 ].…”

Section: 31 P-nmr Chiral Recognitionmentioning

confidence: 99%

Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds

Silva

2017

Molecules

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Nuclear magnetic resonance (NMR) is a powerful tool for the elucidation of chemical structure and chiral recognition. In the last decade, the number of probes, media, and experiments to analyze chiral environments has rapidly increased. The evaluation of chiral molecules and systems has become a routine task in almost all NMR laboratories, allowing for the determination of molecular connectivities and the construction of spatial relationships. Among the features that improve the chiral recognition abilities by NMR is the application of different nuclei. The simplicity of the multinuclear NMR spectra relative to 1H, the minimal influence of the experimental conditions, and the larger shift dispersion make these nuclei especially suitable for NMR analysis. Herein, the recent advances in multinuclear (19F, 31P, 13C, and 77Se) NMR spectroscopy for chiral recognition of organic compounds are presented. The review describes new chiral derivatizing agents and chiral solvating agents used for stereodiscrimination and the assignment of the absolute configuration of small organic compounds.

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Section: 31 P-nmr Chiral Recognitionmentioning

confidence: 99%