2024
DOI: 10.1002/sscp.202300193
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Determination of a novel anti‐influenza pinanamine‐based analog in rat plasma by liquid chromatography‐tandem mass spectrometry and its application in pharmacokinetic evaluations

Xiaoying Lin,
Xin Zhao,
Bin Yang
et al.

Abstract: A pinanamine‐based analog, (1R,2R,3R,5S)‐N‐((3‐cyclopropylthiophen‐2‐yl)methyl)‐2,6,6‐trimethylbicyclo[3.1.1]heptan‐3‐amine (M090) was synthesized and demonstrated with anti‐influenza activity to overcome the multi‐drug resistance. Herein, a rapid and robust liquid chromatography‐tandem mass spectrometry method was developed and validated to quantify M090 in rat plasma. With simple protein precipitation by methanol, the separation of M090 was performed on a Waters BEH‐C18 column (2.1 × 100 mm, 1.7 μm) by gradi… Show more

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