Determination of 7-aminoflunitrazepam in urine by dispersive liquid–liquid microextraction with liquid chromatography–electrospray-tandem mass spectrometry

Melwanki, Mahaveer B.; Chen, Weishan; Bai, Hsin-Yu; Lin, Tzuen-Yeuan; Fuh, Ming‐Ren

doi:10.1016/j.talanta.2008.12.021

Cited by 88 publications

(46 citation statements)

References 17 publications

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“…DLLME has been widely used for the determination of organic compounds in enviromental water samples, such as antioxidants, polycyclic aromatic hydrocarbons, chlorophenols, organophosphorus pesticides, chlorobenzenes, trihalomethanes, phthalate esters in water samples [18][19][20][21][22][23][24]. Recently, its applications have been extended to different matrixes such as food [25][26][27][28], solid samples [29,30] and biological fluids [31][32][33]. A few papers have reported the application of DLLME in urine samples [31,32] and plasma samples [33].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid–liquid microextraction coupled with high‐performance liquid chromatography

Zhang

Jian

Wen

et al. 2011

J of Separation Science

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Dispersive liquid-liquid microextraction (DLLME) coupled with high-performance liquid chromatography (HPLC)-UV detection was applied in rat urine for the extraction and determination of tetrahydropalmatine (THP) and tetrahydroberberine (THB), both active components in Rhizoma corydalis. Various parameters affecting the extraction efficiency, such as the type and volume of extraction and dispersive solvent, pH, etc. were evaluated. Under the optimal conditions (extraction solvent: 37 μL of chloroform, dispersive solvent: 100 μL of methanol, alkaline with 100 μL of 1 mol/L NaOH, and without salt addition), the enrichment factors of THP and THB were more than 30. The extraction recoveries were 69.8-75.8% and 72.7-77.6% for THP and THB in rat urine, respectively. Both THP and THB showed good linearity in the range of 0.025-2.5 μg/mL, and the limit of quantification was 0.025 μg/mL (S/N=10, n=6). The intra-day and inter-day precision of THP and THB were <12.6%. The relative recoveries ranged from 95.5 to 107.4% and 96.8 to 100.9% for THP and THB in rat urine, respectively. The method has been successfully applied to rat urine samples. The results demonstrated that DLLME is a very simple, rapid and efficient method for the extraction and preconcentration of THP and THB from urine samples.

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid–liquid microextraction coupled with high‐performance liquid chromatography

Zhang

Jian

Wen

et al. 2011

J of Separation Science

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“…There have found many applications about it in the enrichment and determination of polycyclic aromatic hydrocarbons, amitriptyline and nortriptyline, copper, palladium, etc. [35][36][37][38][39]. DLLME has many merits, yet toxic solvents such as benzene, chlorobenzene or chloroform have been often used as extraction phase.…”

Section: Introductionmentioning

confidence: 99%

Enrichment and sensitive determination of dichlorodiphenyltrichloroethane and its metabolites with temperature controlled ionic liquid dispersive liquid phase microextraction prior to high performance liquid phase chromatography

Bai

Zhou

Xie

et al. 2009

Analytica Chimica Acta

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“…It possesses many advantages: simple, rapid, cheap, high enrichment factor, high recovery, etc. Up to now, DLLME has been widely applied for the assay of environmental water samples and it also shows good prospect in the analysis of analytes in complex matrices such as biological fluids [18][19][20] .…”

mentioning

confidence: 99%

Dispersive liquid-liquid microextraction combined with high-performance liquid chromatography for the determination of clozapine and chlorpromazine in urine

Chen

Xiong

Ruan

et al. 2011

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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A simple method has been proposed for the determination of clozapine (CLZ) and chlorpromazine (CPZ) in human urine by dispersive liquid-liquid microextraction (DLLME) in combination with high-performance liquid chromatography-ultraviolet detector (HPLC-UV). All important variables influencing the extraction efficiency, such as pH, types of the extraction solvent and the disperser solvent and their volume, ionic strength and centrifugation time were investigated and optimized. Under the optimal conditions, the limit of detection (LODs) and quantification (LOQs) of the method were 13 and 39 ng/mL for CLZ, and 2 and 6 ng/mL for CPZ, respectively. The relative standard deviations (RSDs) of the targets were less than 5.1% (C=0.100 μg/mL, n=9). Good linear behaviors over the tested concentration ranges were obtained with the values of R (2)>0.999 for the targets. The absolute extraction efficiencies of CLZ and CPZ from the spiked blank urine samples were 98.3% and 97.8%, respectively. The applicability of the technique was validated by analyzing urine samples and the mean recoveries for spiked urine samples ranged from 93.3% to 105.0%. The method was successfully applied for the determination of CLZ and CPZ in real human urine.

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Determination of 7-aminoflunitrazepam in urine by dispersive liquid–liquid microextraction with liquid chromatography–electrospray-tandem mass spectrometry

Cited by 88 publications

References 17 publications

Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid–liquid microextraction coupled with high‐performance liquid chromatography

Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid–liquid microextraction coupled with high‐performance liquid chromatography

Enrichment and sensitive determination of dichlorodiphenyltrichloroethane and its metabolites with temperature controlled ionic liquid dispersive liquid phase microextraction prior to high performance liquid phase chromatography

Dispersive liquid-liquid microextraction combined with high-performance liquid chromatography for the determination of clozapine and chlorpromazine in urine

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