Determination of 239Pu in urine by sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) using an automated offline sample preparation technique

Xiao, Ge; Jones, Robert L.

doi:10.1007/s10967-021-07622-1

Cited by 7 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, this impurity test also demonstrated that no observed organic compounds in the urine matrix could interfere with the five actinides. The breakdown of organic materials in the urine matrix by acid digestion thus extended the life span of separation columns, which was further verified in a recent study by Xiao and Jones …”

Section: Resultssupporting

confidence: 58%

“…The breakdown of organic materials in the urine matrix by acid digestion thus extended the life span of separation columns, which was further verified in a recent study by Xiao and Jones. 28 The successful separation of ultratrace actinides using extraction chromatography is related to column efficiency, which is reported as the number (N) of theoretical plates. The greater the number of theoretical plates, the better the potential resolving power of the column.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

High-Throughput Determination of Ultratrace Actinides in Urine by In-Line Extraction Chromatography Combined with Quadrupole Inductively Coupled Plasma Mass Spectrometry (EC-ICP-MS)

2022

Self Cite

View full text Add to dashboard Cite

Determining actinides in urine is vital for occupational exposure monitoring and radiological emergency response because of the toxicity and radiological dose effects of actinides on human health. Traditional radiochemistry analytical methods used to determine actinide concentrations in urine are time-consuming (sample analysis takes several days) and are hindered by a variety of technical and instrumentation-related obstacles. A high-throughput, fully automated, precise, and accurate in-line method was developed for determining five actinides (241Am, 239Pu, 237Np, 232Th, and 238U) at ng/L levels in urine using extraction chromatography combined with quadrupole inductively coupled plasma mass spectrometry (EC-ICP-MS). In this method, the five actinides were successfully separated with the required sensitivity, peak shape, and resolution using a simplified single Eichrom TRU column with a Dionex ICS-5000 system. The separated actinides were subsequently injected into an in-line PerkinElmer (PE) NexION 300D ICP-MS for quantitative determination. The sample-to-sample run time was 23 min for automatic chemical separation and quantification using only 0.5 mL of urine. The limits of detection (LOD) obtained using this method were 0.015, 0.022, 0.039, 4.5, and 2.4 ng/L for 241Am, 239Pu, 237Np, 232Th, and 238U, respectively. The method routinely had a chemical yield of >84% as well as a linearity (R 2) coefficient of ≥0.999 for the calibrators. The method proved to be rapid, reliable, and effective for actinide quantification in urine and therefore is appropriate for radiological emergency response incidents.

show abstract

Section: Resultssupporting

confidence: 58%

Section: ■ Results and Discussionmentioning

confidence: 99%

High-Throughput Determination of Ultratrace Actinides in Urine by In-Line Extraction Chromatography Combined with Quadrupole Inductively Coupled Plasma Mass Spectrometry (EC-ICP-MS)

2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…But it was difficult to accurately control the flow rate in this gas pressure mode. A prepFAST MC chromatography system [11] was launched by Elemental Scientific (ESI Omaha, NE, USA) for isotopic sample preparation [12][13][14][15][16][17][18]. It used a syringe system to drive the eluent through the column and enabled precise control over the eluent flow rate.…”

Section: Introductionmentioning

confidence: 99%

An automated parallel multi‐channel chromatographic system for isotopic analysis – Demonstration considering Sr

Peng

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

A fully automated, closed‐column chromatographic system with parallel multi‐channel has been developed. This system is established with seven reagent reservoirs, one multi‐channel syringe pump, eight 10‐port valves, forty sample tubes, 40 columns, and a fraction collection tray. Four samples can be purified simultaneously at a time, and 40 samples can be purified in one batch. Each sample can be purified by an independent channel, avoiding cross‐contamination. The sample tubes can be flipped upside down for automatic cleaning, which eliminates the residue of samples. Moreover, the fraction collection tray can collect up to 104 different target components. The key performance of the system has been investigated. The results show that the sample tubes are well‐cleaned, the bubble does not affect the chemical behavior of columns, the consistency of the parallel channels is excellent and the blank of the system is negligible. The system was demonstrated by the purification of Sr from reference materials (BCR‐2, JB‐2, JB‐3, and NIST SRM 987). The recoveries of Sr are better than 89.4% and the blank of the whole procedure is less than 200 pg. The Sr isotope values agree well with the reference values.

show abstract

“…Online SPE–ICP–MS is an automatic sequential analytical technology characterized by good repeatability and high-speed data acquisition. By virtue of these advantages, coupled SPE–ICP–MS systems have been widely employed to monitor environmental radioactivity. − For radionuclide analysis, this coupled system provides radiological protection to operators by suppressing the exposure dose. For example, the system is useful for monitoring radioactivity during the decommissioning of nuclear power plants.…”

Section: Introductionmentioning

confidence: 99%

Online Solid-Phase Extraction–Inductively Coupled Plasma–Quadrupole Mass Spectrometry with Oxygen Dynamic Reaction for Quantification of Technetium-99

et al. 2021

View full text Add to dashboard Cite

Quantification of pg/L levels (i.e., 0.6 mBq/L) of radioactive technetium-99 (99Tc) was achieved within 15 min in the presence of isobaric and polyatomic interference sources such as ruthenium-99 (99Ru) and molybdenum hydride (98Mo1H) at 3–11 orders of magnitude higher concentrations. Online solid-phase extraction–inductively coupled plasma–quadrupole mass spectrometry (ICP–QMS) with oxygen (O2) dynamic reaction cell (online SPE–ICP–MS–DRC) was shown to be a thorough automatic analytical system, circumventing the need for human handling. At three stepwise separations (SPE–DRC–Q mass filters), we showed that interference materials allowed the coexistence of abundance ratios of 1.5 × 10–13 and 1.1 × 10–5 for 99Tc/Mo and 99Tc/Ru, respectively. A classical mathematical correction using the natural isotope ratio of 99Ru/102Ru was used to calculate the residues of 99Ru. Using this optimized system, a detection limit (DL; 3σ) of 99Tc was 9.3 pg/L (= 5.9 mBq/L) for a 50 mL injection and sequential measurements were undertaken at a cycle of 24 min/sample. For the measurement of a lower concentration of 99Tc, an AG1-X8 anion-exchange column was used to study 20 L of seawater. Its DL was approximately 1000 times greater than that of previous methods (70.0 fg/L). Thus, this method withstands coexistences of 5.8 × 10–18 and 3.5 × 10–9 for 99Tc/Mo and 99Tc/Ru, respectively. Spike and recovery tests were conducted for environmental samples; the resulting values showed good agreement with the spike applied.

show abstract

Determination of 239Pu in urine by sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) using an automated offline sample preparation technique

Cited by 7 publications

References 19 publications

High-Throughput Determination of Ultratrace Actinides in Urine by In-Line Extraction Chromatography Combined with Quadrupole Inductively Coupled Plasma Mass Spectrometry (EC-ICP-MS)

High-Throughput Determination of Ultratrace Actinides in Urine by In-Line Extraction Chromatography Combined with Quadrupole Inductively Coupled Plasma Mass Spectrometry (EC-ICP-MS)

An automated parallel multi‐channel chromatographic system for isotopic analysis – Demonstration considering Sr

Online Solid-Phase Extraction–Inductively Coupled Plasma–Quadrupole Mass Spectrometry with Oxygen Dynamic Reaction for Quantification of Technetium-99

Contact Info

Product

Resources

About