Determination of 2- and 3-MCPD as well as 2- and 3-MCPD Esters and Glycidyl Esters (GE) in Infant and Adult/Pediatric Nutritional Formula by Gas Chromatography Coupled to Mass Spectrometry Method, First Action 2018.03

Dubois, Mathieu; Empl, Anna-Maria; Jaudzems, Greg; Baslé, Quentin; Konings, Erik J M

doi:10.5740/jaoacint.18-0266

Cited by 36 publications

(35 citation statements)

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“…Volumes were corrected for body surface area (BSA). BSA was calculated according to the Dubois formula [ 25 ]. In QMass LV contours were drawn manually and focused on adequate tracking of the myocardium for precise strain analysis.…”

Section: Methodsmentioning

confidence: 99%

Left ventricular global longitudinal strain in bicupsid aortic valve patients: head-to-head comparison between computed tomography, 4D flow cardiovascular magnetic resonance and speckle-tracking echocardiography

Hoven

Yilmazer

Chelu

et al. 2020

Int J Cardiovasc Imaging

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Left ventricular global longitudinal strain (LVGLS) analysis is a sensitive measurement of myocardial deformation most often done using speckle-tracking transthoracic echocardiography (TTE). We propose a novel approach to measure LVGLS using feature-tracking software on the magnitude dataset of 4D flow cardiovascular magnetic resonance (CMR) and compare it to dynamic computed tomography (CT) and speckle tracking TTE derived measurements. In this prospective cohort study 59 consecutive adult patients with a bicuspid aortic valve (BAV) were included. The study protocol consisted of TTE, CT, and CMR on the same day. Image analysis was done using dedicated feature-tracking (4D flow CMR and CT) and speckle-tracking (TTE) software, on apical 2-, 3-, and 4-chamber long-axis multiplanar reconstructions (4D flow CMR and CT) or standard apical 2-, 3-, and 4-chamber acquisitions (TTE). CMR and CT GLS analysis was feasible in all patients. Good correlations were observed for GLS measured by CMR (− 21 ± 3%) and CT (− 20 ± 3%) versus TTE (− 20 ± 3%, Pearson’s r: 0.67 and 0.65, p < 0.001). CMR also correlated well with CT (Pearson’s r 0.62, p < 0.001). The inter-observer analysis showed moderate to good reproducibility of GLS measurement by CMR, CT and TTE (Pearsons’s r: 0.51, 0.77, 0.70 respectively; p < 0.05). Additionally, ejection fraction (EF), end-diastolic and end-systolic volume measurements (EDV and ESV) correlated well between all modalities (Pearson’s r > 0.61, p < 0.001). Feature-tracking GLS analysis is feasible using the magnitude images acquired with 4D flow CMR. GLS measurement by CMR correlates well with CT and speckle-tracking 2D TTE. GLS analysis on 4D flow CMR allows for an integrative approach, integrating flow and functional data in a single sequence. Not applicable, observational study. Electronic supplementary material The online version of this article (10.1007/s10554-020-01883-9) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Left ventricular global longitudinal strain in bicupsid aortic valve patients: head-to-head comparison between computed tomography, 4D flow cardiovascular magnetic resonance and speckle-tracking echocardiography

Hoven

Yilmazer

Chelu

et al. 2020

Int J Cardiovasc Imaging

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“…Infant formula is a unique matrix since it has quite diverse raw materials with varying lipid content. For powdered formula, its structure is very dependent on the ingredients and processing, which causes the unique matrix structure and challenging to extract its lipid (Dubois et al ., 2019). The efficiency of lipid extraction method depends greatly on the compatibility of the sample and its solvent, both physically and chemically.…”

Section: Resultsmentioning

confidence: 99%

“…The fourth method still used the step of Arisseto et al ., (2017) method, but the solvents replaced with isohexane and acetone (80:20), referring to the solvent application by Wohrlin et al ., (2015). The last method was the lipid extraction method by Dubois et al ., (2019) performed with ethyl acetate solvent.…”

Section: Resultsmentioning

confidence: 99%

The comparison of several lipid extraction methods on infant formula for 3‐monochloropropanediol esters and glycidyl esters analysis

Faridah

Ulfa

Andarwulan

2021

Int J of Food Sci Tech

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Summary This study aimed to determine the best lipid extraction method for infant formula; therefore, it can be used as a routine analysis. The samples were some commercial infant formulas in Indonesia. The research was conducted with three steps: (i) Lipid extraction of infant formula using five lipid extraction methods; (ii) 3‐monochloropropanediol esters (3‐MCPDE) and glycidyl esters (GE) analysis of lipid extract from three lipid extraction methods in the first step; and (iii) 3‐MCPDE and GE analysis of six commercial infant formulas using the best lipid extraction method. The results showed that lipid extraction using the Dubois method gave the best results than other lipid extraction methods. The level of 3‐MCPDE and GE also had no significant difference with the addition of NaCl in the Folch method, compared with the addition of Na2SO4. The level of 3‐MCPDE and GE using the Dubois method was significantly different and higher compared with the other lipid extraction methods. 3‐MCPDE and GE levels of commercial infant formula were 6.62–52.84 µg kg−1 and <1.43–17.06 µg kg−1, respectively. The values obtained were still within the standard according to Commission Regulation EU 2018/290 by the European Food Safety Authority (125 µg kg−1 for 3‐MCPDE (on progress) and 50 µg kg−1 for GE).

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“…Referencin g from published results of other works [13,15] and preliminary experiments, the procedure for extracting fatty acid esters of MCPDs from infant formula was developed as followed: About 1.0 g of homogenized sample, accurately weighed, was dissolved in 15 mL of distilled water and transferred into a 100 mL separation funnel. Before extracting the aqueous liquid with organic solvent, 0.25 mL of solution A was added into the separation funnel, and the funnel was gently shaken in 10 second to mix.…”

Section: Sample Pretreatmentmentioning

confidence: 99%

“…And because MCPDs in food is considered as a serious health issue, AOAC International has also provided a Standard Method Performance Requirements (SPMR) for any analytical method to be used for determination of 2MCPD, 3MCPD, esters of 2 and 3MCPD as well as glycidyl esters in nutritional formula [14]. AOAC International has adopted the GCMS method for the determination of 2MCPD, 3MCPD and glycidyl esters (GE) in nutritional formula [15]. This method, however, monitors only one ion for each analyte, which may affect the method specificity in some complex matrices.…”

Section: Introductionmentioning

confidence: 99%

Xác định đồng thời các dạng ester của 3-MCPD và 2-MCPD trong sữa công thức bằng GC-MS/MS

Dinh¹,

Nhu²,

Ngoc³

et al. 2020

VJFC

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Nghiên cứu đã phát triển và thẩm định phương pháp xác định đồng thời các dạng ester của 3-MCPD và 2-MCPD trong sữa công thức bằng GC-MS/MS. Các ester của MCPD được chiết từ mẫu sữa công thức bằng hỗn hợp ethanol/n-hexane/diethyl ether (1/1/1, v/v/v), sau đó được xử lý với acid sulfuric để giải phóng dạng tự do. Các chất 3-MCPD và 2-MCPD dạng tự do và nội chuẩn đồng vị 3-MCPD-d5 and 2-MCPD-d5 được dẫn xuất với acid phenylboronic và sau đó dẫn xuất được phân tích bằng GC-MS/MS ở chế độ MRM. Cột tách được sử dụng là cột mao quản DB-5MS, khí mang là Heli ở tốc độ 1 mL/phút. Chế độ MRM đã được sử dụng để lựa chọn 1 ion mẹ và 2 ion con cho mỗi chất phân tích. Kết quả thẩm định cho thấy phương pháp đáp ứng các yêu cầu theo AOAC SMPR. Phương pháp đã được ứng dụng để xác định các ester của 3-MCPD và 2-MCPD trong các mẫu sữa công thức lấy ở một số tỉnh, thành phố của Việt Nam. Có 38,9% số mẫu phát hiện 3-MCPD ester và 34,7% số mẫu phát hiện 2-MCPD ester.

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Determination of 2- and 3-MCPD as well as 2- and 3-MCPD Esters and Glycidyl Esters (GE) in Infant and Adult/Pediatric Nutritional Formula by Gas Chromatography Coupled to Mass Spectrometry Method, First Action 2018.03

Cited by 36 publications

References 0 publications

Left ventricular global longitudinal strain in bicupsid aortic valve patients: head-to-head comparison between computed tomography, 4D flow cardiovascular magnetic resonance and speckle-tracking echocardiography

Left ventricular global longitudinal strain in bicupsid aortic valve patients: head-to-head comparison between computed tomography, 4D flow cardiovascular magnetic resonance and speckle-tracking echocardiography

The comparison of several lipid extraction methods on infant formula for 3‐monochloropropanediol esters and glycidyl esters analysis

Xác định đồng thời các dạng ester của 3-MCPD và 2-MCPD trong sữa công thức bằng GC-MS/MS

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