Determination of 2,4,6-triiodophenol and its metabolites in human urine by anion-exchange chromatography with ICP-MS detection

Wuilloud, Rodolfo G.; Selar, Niranjan; Kannamkumarath, Sasi S.; Caruso, Joseph A.

doi:10.1039/b404944f

Cited by 13 publications

(11 citation statements)

References 29 publications

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“…The LOD obtained in this work are comparable to previous results with CE separation [7,[23][24][25][26]. Compared to conventional LC-ICP-MS detection limit for bromine and iodine speciation analysis [6,10,11,14], these CE-ICP-MS values are poorer, mainly because of the smaller sample size (8 nL) and/or dilution by the make-up solution. However, CE separation offers better resolution with less reagent and sample volume.…”

Section: Analytical Figures Of Merit At Optimized Electrophoretic Sepsupporting

confidence: 88%

“…It is important to have a highly sensitive analytical method available for their determination after separation. Several methods of ion chromatography (IC), LC, size-exclusion chromatography (SEC), and CE coupled with different detection methods for iodine and bromine speciation analysis have appeared, including UV detection [2,7,8], inductively coupled plasma optical emission spectrometry (ICP-OES) [9,10], and ICP-MS [2,[10][11][12][13][14][15]. The utility of CE for speciation analysis is growing rapidly [16].…”

Section: Introductionmentioning

confidence: 99%

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Determination of iodine and bromine compounds in foodstuffs by CE‐inductively coupled plasma MS

Chen¹,

Wang²,

Jiang³

2007

Electrophoresis

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A CE-inductively coupled plasma mass spectrometric (CE-ICP-MS) method for iodine and bromine speciation analysis is described. Samples containing ionic iodine (I(-) and IO(3)(-)) and bromine (Br(-) and BrO(3)(-)) species are subjected to electrophoretic separation before injection into the microconcentric nebulizer (CEI-100). The separation has been achieved in a 50 cm length x 75 microm id fused-silica capillary. The electrophoretic buffer used is 10 mmol/L Tris (pH 8.0), while the applied voltage is set at -8 kV. Detection limits are 1 and 20-50 ng/mL for various I and Br compounds, respectively, based on peak height. The RSD of the peak areas for seven injections of 0.1 microg/mL I(-), IO(3)(-) and 1 microg/mL Br(-), BrO(3)(-) mixture is in the range of 3-5%. This method has been applied to determine various iodine and bromine species in NIST SRM 1573a Tomato Leaves reference material and a salt and seaweed samples obtained locally. A microwave-assisted extraction method is used for the extraction of these compounds. Over 87% of the total iodine and 83% of the total bromine are extracted using a 10% m/v tetramethylammonium hydroxide (TMAH) solution in a focused microwave field within a period of 10 min. The spike recoveries are in the range of 94-105% for all the determinations. The major species of iodine and bromine in tomato leaves, salt, and seaweed are Br(-), IO(3)(-), I(-), and Br(-), respectively.

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Section: Analytical Figures Of Merit At Optimized Electrophoretic Sepsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Determination of iodine and bromine compounds in foodstuffs by CE‐inductively coupled plasma MS

Chen¹,

Wang²,

Jiang³

2007

Electrophoresis

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“…The detection limits obtained in this work were better than previous results with similar techniques, possibly due to the lower background offered by DRC. [9][10][11][12][13][14][15] Determination of iodine and bromine species in water and urine samples…”

Section: Selection Of Drc Conditionsmentioning

confidence: 99%

“…Several methods of ion chromatography (IC), liquid chromatography (LC), size-exclusion chromatography (SEC) and capillary electrophoresis (CE) coupled with different detection methods for iodine and bromine speciation have appeared, including UV detection, 2,6,7 inductively coupled plasma optical emission spectrometry (ICP-OES), 8,9 and inductively coupled plasma mass spectrometry (ICP-MS). 2,[9][10][11][12][13][14][15][16] However, all four species, namely Br − , BrO3 − , I − and IO3 − , have not been reported using a single procedure.…”

Section: Introductionmentioning

confidence: 99%

Determination of Iodine and Bromine Compounds by Ion Chromatography/Dynamic Reaction Cell Inductively Coupled Plasma Mass Spectrometry

Wang

Jiang

2008

ANAL. SCI.

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An inductively coupled plasma mass spectrometer (ICP-MS) was used as an ion chromatographic detector for the speciation of iodine and bromine. Gradient elution using NH4NO3 at pH 10 allowed the chromatographic separation of ionic iodine (I − and IO3 − ) and bromine (Br − and BrO3 − ) species in less than 8 min. Effluents from the ion-exchange column were delivered to the nebulization system of ICP-MS for the determination of I and Br. The potentially interfering 38 Ar 40 ArH + and 40 Ar 40 ArH + at the bromine masses m/z 79 and 81 were significantly reduced in intensity (by approximately two orders of magnitude) by using 0.6 mL min −1 O2 as a reactive cell gas in the dynamic reaction cell (DRC). Moreover, the signal-to-background ratio at iodine mass m/z 127 increased significantly when O2 was used as the reaction gas. The detection limits were in the range of 0.001 -0.002 and 0.03 -0.04 ng mL −1 for various I and Br compounds, respectively, based on the peak height. The relative standard deviation of the peak areas for five injections of a 2 ng mL −1 I − , IO3 − and 20 ng mL −1 Br − , BrO3 − mixture was in the range of 3 -4%. The concentrations of I and Br compounds have been determined in selected water and urine samples. The spike recoveries were in the range of 94 -102% for all of the determinations. This method has also been applied to determine various I and Br compounds in an NIST RM 8435 whole-milk powder reference material and a seaweed sample obtained locally. A microwave-assisted extraction method was used to extract these compounds, which were quantitatively leached with a 10% mass/volume (m/v) tetramethylammonium hydroxide (TMAH) solution in a focused microwave field within a period of 6 min. The major components of I and Br in milk powder and seaweed were I − and Br − .

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“…It is invaluable as a detector when used in conjunction with liquid or ion chromatography [15][16][17][18][19] or capillary electrophoresis [20] for speciation studies.…”

Section: Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

Analytical Methods for Iodine and Iodides

Kanoh

Konishi

2014

Iodine Chemistry and Applications

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Determination of 2,4,6-triiodophenol and its metabolites in human urine by anion-exchange chromatography with ICP-MS detection

Cited by 13 publications

References 29 publications

Determination of iodine and bromine compounds in foodstuffs by CE‐inductively coupled plasma MS

Determination of iodine and bromine compounds in foodstuffs by CE‐inductively coupled plasma MS

Determination of Iodine and Bromine Compounds by Ion Chromatography/Dynamic Reaction Cell Inductively Coupled Plasma Mass Spectrometry

Analytical Methods for Iodine and Iodides

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