Determination of 1-hydroxypyrene in children urine using column-switching liquid chromatography and fluorescence detection

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

“…Higher levels have been noted in residents of industrialized and high traffic urban areas compared with rural or suburban settings, and the mean urinary 1-hydroxypyrene levels from the former group were somewhat higher than in the NHANES 2003-2004 subsample (Kanoh et al, 1993;Kuo et al, 2004;Yang et al, 2003). Variation also has been noted in the mean 1-hydroxypyrene urine levels between different industrialized countries (for example, South Korea or China, compared to the U.S.), which is attributable to such factors as ambient air pollution and residential heating and cooking sources (Huang et al, 2004;Kuo et al, 2004;Roggi et al, 1997;Siwinska et al, 1999;Yang et al, 2003).…”

“…Variation also has been noted in the mean 1-hydroxypyrene urine levels between different industrialized countries (for example, South Korea or China, compared to the U.S.), which is attributable to such factors as ambient air pollution and residential heating and cooking sources (Huang et al, 2004;Kuo et al, 2004;Roggi et al, 1997;Siwinska et al, 1999;Yang et al, 2003). In general, smokers have about 2 to 4-fold higher urinary 1-hydroxypyrene levels than non-smokers (Goen et al, 1995;Jacob et al, 1999).…”

Simultaneous determination of α-naphthol, β-naphthol and 1-hydroxypyrene in urine by synchronous fluorescence spectrometry using β-cyclodextrin as a sensitiser

“…Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants of great concern because many of them are well-known carcinogens and mutagens [1][2][3][4][5]. Biological monitoring is an effective way to quantitate the internal exposure to PAHs and estimate health risks due to PAHs exposure [4][5][6].…”

“…Biological monitoring is an effective way to quantitate the internal exposure to PAHs and estimate health risks due to PAHs exposure [4][5][6]. This was usually performed by measuring PAHs hydroxides in urine samples [3][4][5][6]. 1-Hydroxypyrene (1-OHP) is the main metabolite of pyrene and has been used as a biomarker of occupational exposure to PAHs [3][4][5]7].…”

Fast and simple method for the determination of urinary 1‐hydroxypyrene

“…In 2004, Kuo et al developed a column-switching LC technique to determine urinary 1-OHPy after acid hydrolysis and solvent extraction for the sample. The proposed method is practicable, reliable, and particularly attractive for routine analyzes [13]. However, this method does not avoid solvent handling before injection in the analytical system.…”