Determination of 1-Deoxynojirimycin by a developed and validated HPLC-FLD method and assessment of In-vitro antioxidant, α-Amylase and α-Glucosidase inhibitory activity in mulberry varieties from Turkey

Eruygur, Nuraniye; Dural, Emrah

doi:10.1016/j.phymed.2018.09.016

Cited by 37 publications

(17 citation statements)

References 22 publications

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“…In Chinese medicine, they have long been used to treat fevers, improve eyesight, protect the liver, modulate dendritic cell maturation, and strengthen joints [4,5]. Leaves have also been applied in antibacterial [1,6], anti-diabetic [6,7], antioxidant [6,7,8,9,10], and anti-obesity [11] treatments. In Japan and Korea, patients with diabetes consume mulberry leaves as an anti-hyperglycemic supplement, while in east and southeast Asia, the drinking of mulberry tea, which is richer in γ-aminobutyric acid than green tea, is very popular.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on the Phenolic Composition and Biological Activities of Morus alba L. Commercial Samples

et al. 2019

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Morus alba L. (white mulberry) has been commonly used as a functional food and for medicinal purposes. Hence, the aim of the study was to compare the phenolic profile of white mulberry commercial samples in relation to their antioxidant potential and acetylcholinesterase (AChE) inhibitory activity. It is of interest to determine whether herbal products originating from different commercial sources differ in their phenolic profiles. For this purpose, a simple and rapid high-performance liquid chromatography (HPLC) method was used for the separation and determination of ten major phenolic compounds. Total phenolic (TPC), total flavonoid (TFC), and total phenolic acid contents (TPAC), as well as l(+)-ascorbic acid (ASA) contents, were determined. The antioxidant potential was assessed by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) scavenging activity and ferric-reducing/antioxidant power (FRAP) assay, while the AChE inhibitory activity was determined by the Ellman assay for water extracts. The study revealed that excluding two herbal products containing fruits and a sample containing leaves of white mulberry, yerba mate and lemon, the remaining samples were generally consistent in terms of phenolic composition as well as antioxidant potential and AChE inhibitory activity. This reflects the health-promoting properties of the samples under study. Moreover, the results showed that the water extracts of white mulberry were richer in phenolic compounds and presented higher antioxidant activity than the hydromethanolic extracts. However, the water extracts showed low inhibitory activity against AChE. Moreover, the correlation analysis indicated a high positive relationship between phenolic composition and antioxidant activity in extracts of white mulberry. Overall, the obtained results may be useful in the evaluation of new dietary supplements and food products. The water extracts of white mulberry could be used for antioxidant purposes, while the hydromethanolic extracts could be incorporated in antioxidant formulations.

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Section: Introductionmentioning

confidence: 99%

A Comparative Study on the Phenolic Composition and Biological Activities of Morus alba L. Commercial Samples

et al. 2019

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“…In short, the present study shows that DFMS played a positive effect in T2DM mice that could reduce blood sugar level, improve blood lipid and oxidative stress level, regulate abundance of gut microbial, which is possibly related to its low carbohydrate content and the high levels of 1-deoxyricogen and probiotic. It has to be proved that 1-deoxyricogen is able to suppress the α-glucosidase, restraining the decomposition of disaccharides into glucose, and inhibit the metabolic effects of carbohydrates, optimize the enrichment and composition of gut microbiota, repair pancreatic cells, and then improve insulin resistance (Li et al, 2019;Nea & Ed, 2019). In addition, probiotic has the ability to adapt to the human intestinal environment, improve the intestinal micro-ecosystem, regulate the abundance and composition of gut microbiota, and then ameliorate the glycolipid metabolism of the human body (Wang, Cheng, et al, 2019;Wang, Shang, et al, 2019).…”

Section: Effect Of Dfms On Gut Microbial Compositionmentioning

confidence: 99%

“…In addition, the nutrient and chemical compound of fermented mulberry were presented in Table 1, and fermented mulberry contains 3.8-18.54 mg/g protein, 21.2-30.46 mg/g total polyphenols, 0.3-6.65 mg/g total flavonoids, 0.67-2.23 mg/g 1-deoxyricogen, and 0.5-2.86 mg/g anthocyanin. As we know that these nutrients and bioactive compounds of fermented mulberry play a central role in hypoglycemic activity in diabetic mice, especially the 1-deoxyricogen, which has the ability to inhibit the metabolic effect of carbohydrates, repair pancreatic cells and then improve insulin resistance (Li et al, 2019;Nea & Ed, 2019), thus the higher 1-deoxyricogen of fermented mulberry showed the better hypoglycemic effect. Moreover, 1-deoxyricogen of mulberry exhibits gender-specific modulating effects on hypercholesteremia and gut microbiota, which has significantly decreased the relative abundance of Fimicutes, and increased the abundance of Akkermansia, a beneficial genus with obesity and diabetes (Hou et al, 2020;Li et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The hypoglycemic effect of freeze‐dried fermented mulberry mixed with soybean on type 2 diabetes mellitus

Long

Pang

et al. 2021

Food Science & Nutrition

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Mulberry has significant hypoglycemic effect and can be used as an auxiliary food for people with type 2 diabetes. However, it is rich in carbohydrate and cannot be consumed directly by diabetic patients. In the study, we fermented the mulberry to reduce the content of glucose and fructose, and added the soybean to reduce the loss of probiotics during fermentation and then determined its hypoglycemic effect. We induced type 2 diabetes mellitus (T2DM) mice by streptozotocin and measured its blood glucose, serum biochemistry, hepatic and pancreatic histopathology, and the diversity of the gut microbiota. After 5 weeks of oral DFMS administration, the glucose tolerance was improved significantly in T2DM mice. Furthermore, there were also significant increases in superoxide dismutase activity and glutathione concentration, and marked reductions in the concentrations of malondialdehyde and free fatty acids. Moreover, DFMS also prevented histopathological changes and the increases in the activities of alanine transaminase and aspartate transaminase. DFMS treatment also markedly increased the richness of the gut microbial community. The abundance of Bacteroidetes was increased, and those of Proteobacteria, Escherichia‐Shigella, and Lactobacillus were reduced. In summary, DFMS has a clear hypoglycemic effect in mice with T2DM.

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“…Post run was set at 300 °C for 2 min. Total run time was 60 minutes [16].…”

Section: Gas Chromatography-mass Spectrometry (Gc/ms) and Gc Analysis Of Extractsmentioning

confidence: 99%

Some Quality Criteria of Valerian (Valeriana dioscoridis Sm.) Growing in Different Environments

Sözmen

Ataş

Çilesiz

et al. 2020

International Journal of Secondary Metabolite

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Valerian (Valeriana dioscoridis Sm.) is a perennial herb of the Caprifoliaceae family. The genus Valeriana L. is represented by 14 species (15 taxa) in Turkey. This plant contains flavone glycosides, iridoids and lignans. Among these components, the medically important active ingredient is valerianic acid. Essential oils from valerian roots and rhizomes are used for the treatment of various diseases, including insomnia, mental illness, anxiety, menstrual cramps and physical stress conditions. In this study, evaluations were made of the root and rhizome of valerian plants grown in a natural environment and in greenhouse condition. The macro and micro nutrient contents of the powdered plant samples, and the antioxidant and antimicrobial activity values of the extracts were reported. Except for some macro and micro elements, it was determined that antioxidant and antimicrobial activities of plants cultivated and grown in nature were not different. The major components of both the natural and cultivated forms were determined to be 9- Borabicyclo [3.3.1] nonane, propyl]-(17.55% and 22.65%, respectively). The heavy metales such as Fe (415.21±47.8 mg/kg), Cu (50.9±0.2 mg/kg) and Mn (274.6±9.5 mg/kg), were obtained above limit values in grown plants of natural environment conditions.

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Determination of 1-Deoxynojirimycin by a developed and validated HPLC-FLD method and assessment of In-vitro antioxidant, α-Amylase and α-Glucosidase inhibitory activity in mulberry varieties from Turkey

Cited by 37 publications

References 22 publications

A Comparative Study on the Phenolic Composition and Biological Activities of Morus alba L. Commercial Samples

A Comparative Study on the Phenolic Composition and Biological Activities of Morus alba L. Commercial Samples

The hypoglycemic effect of freeze‐dried fermented mulberry mixed with soybean on type 2 diabetes mellitus

Some Quality Criteria of Valerian (Valeriana dioscoridis Sm.) Growing in Different Environments

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