Determination by the SRID Method of Normal Values of Serum Apolipoproteins (A-I, A-II, B, C-II, C-III, and E) in Normolipidemic Healthy Japanese Subjects

Goto, Yuichiro; Akanuma, Yasuo; Harano, Yutaka; Hata, Yutaka; Itakura, Hiroshige; Kajiyama, Goro; Kawade, Masato; Koga, Shunichi; Kuzuya, Fumio; Maruhama, Yoshisuke; Matsuzawa, Yūji; Murai, Atsushi; Murase, Toshio; Naito, Chikayuki; Nakai, Tsuguhiko; Noma, Akio; Saitoh, Yasushi; Sasaki, Jun; Takeuchi, Nozomu; Tamachi, Hiromitsu; Uzawa, Haruo; Yamamoto, Akira; Yamazaki, Suzuko; Yasugi, Tadao; Yukawa, Susumu

doi:10.3164/jcbn.1.73

Cited by 95 publications

(12 citation statements)

References 23 publications

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“…*Data expressed as mean 2 S.D heparin-Ca2 + precipitation. Serum apolipoprotein concentrations were measured with a single radial immunodiffusion method using commercial kits from Daiichi Chemical Co. (Osaka, Japan) (24). Serum lipoproteins were separated on preparative sequential ultracentrifugation according to the method of Have1 et al (25).…”

Section: Methodsmentioning

confidence: 99%

Decrease of hepatic triglyceride lipase levels and increase of cholesteryl ester transfer protein levels in patients with primary biliary cirrhosis: Relationship to abnormalities in high-density lipoprotein

et al. 1993

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Serum levels of high-density lipoprotein cholesterol are often increased in patients with primary biliary cirrhosis. To elucidate the mechanism of the elevation of high-density lipoprotein cholesterol levels in this disease, lipoprotein abnormalities were analyzed in 10 patients subdivided into two groups according to concentration of high-density lipoprotein cholesterol. Activities and protein masses of lipoprotein lipase, hepatic triglyceride lipase and cholesteryl ester transfer protein were also determined. Serum high-density lipoprotein cholesterol concentration exceeded 90 mg/dl in 5 of 10 patients. Lipoprotein particles in the high-density lipoprotein2 fraction (with density between 1.063 and 1.125 gm/ml) were enriched with apolipoprotein E and larger in size than those of normal controls. In patients with and without hyperalphalipoproteinemia, hepatic triglyceride lipase activity was significantly decreased (p < 0.05); this was due to the reduction of its protein mass. Lipoprotein lipase activity and protein mass were normal. It is noteworthy that increases in cholesteryl ester transfer protein activity and mass were observed. The enhancement of cholesteryl ester transfer protein activity was more remarkable in the patients with hyperalphalipoproteinemia than in those without hyperalphalipoproteinemia. Because a significant positive correlation was demonstrated between activity and protein mass (r = 0.90, p < 0.001), the increase of cholesteryl ester transfer protein activity may be attributed to the increase of its protein mass. These data suggest that the decrease of hepatic triglyceride lipase levels at least partly explains the appearance of apolipoprotein E-rich large high-density lipoprotein particles in patients with primary biliary cirrhosis.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Methodsmentioning

confidence: 99%

Decrease of hepatic triglyceride lipase levels and increase of cholesteryl ester transfer protein levels in patients with primary biliary cirrhosis: Relationship to abnormalities in high-density lipoprotein

et al. 1993

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“…Plasma apolipoprotein in the patient was determined by the immunoturbidimetric method using a kit obtained from Daiichi Kagaku Co. (Tokyo, Japan) 4 . Findings were: AI 142 mg/dL (normal range, 95–180 mg/dL); AII 25 mg/dL (20–40 mg/dL); B 264 mg/dL (45–125 mg/dL); CII 7.7 mg/dL (1.1–7.0 mg/dL); CIII 9.9 mg/dL (4.4–14.0 mg/dL); and E 8.8 mg/dL (2.2–8.0 mg/dL).…”

Section: Case Reportmentioning

confidence: 99%

A case of pseudohomozygous type II hyperlipoproteinemia in early infancy

Tamaki

Fujieda

Maeda³

et al. 2011

Pediatrics International

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“…Serum total cholesterol and triglyceride concentrations were determined by enzymatic methods with commercial kits. Serum concentrations of apolipoprotein (Apo) AI, AII, B, CII, CIII and E were determined by a single radial immunodiffusion method using commercial kits (Daiichi Chemical Co., Tokyo, Japan) [9]. Serum contents of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) lipids were analysed by ultracentrifugation in an LpTi Rotor (Beckman, Tokyo, Japan) [8].…”

Section: Serum Lipid Lipoprotein and Apolipoprotein Analysesmentioning

confidence: 99%

Inheritable abnormal lipoprotein metabolism in Werner's syndrome similar to familial hypercholesterolaemia

Mori

Yokote

Morisaki

et al. 1990

Eur J Clin Investigation

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Studies were made on the abnormality of lipoprotein metabolism and its cause in 10 patients with Werner's syndrome. Seven of the 10 patients had hypercholesterolaemia (above 250 mg dl-I). Six of the seven patients with hypercholesterolaemia had thickened Achilles' tendons (> 9 mm). A significant positive correlation (P < 0.01) was found between the serum total cholesterol levels and the thickness of Achilles' tendons in these 10 patients, suggesting that the substance precipitated in the thickened tendons is derived from serum cholesterol. Some first-degree relatives of three patients with both hypercholesterolaemia and xanthoma-like thickening of Achilles' tendons also suffered from hypercholesterolaemia. Moreover, the low density lipoprotein (LDL) receptor activities in peripheral lymphocytes of five patients with both hypercholesterolaemia and xanthoma-like tendons were significantly (P < 0.001) lower than those of controls, whereas the LDL receptor activities of two patients without hypercholesterolaemia were almost the same as those of controls. These findings suggest that, at least these five patients with lower lymphocyte LDL receptor activities, and probably another patient with both hypercholesterolaemia and xanthoma-like thickening of Achilles' tendons suffered from familial hypercholesterolaemia (FH). If this is the case, this high frequency of association of Werner's syndrome with FH (in six of 10 patients) suggests some relationship between these two diseases.

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Determination by the SRID Method of Normal Values of Serum Apolipoproteins (A-I, A-II, B, C-II, C-III, and E) in Normolipidemic Healthy Japanese Subjects

Cited by 95 publications

References 23 publications

Decrease of hepatic triglyceride lipase levels and increase of cholesteryl ester transfer protein levels in patients with primary biliary cirrhosis: Relationship to abnormalities in high-density lipoprotein

Decrease of hepatic triglyceride lipase levels and increase of cholesteryl ester transfer protein levels in patients with primary biliary cirrhosis: Relationship to abnormalities in high-density lipoprotein

A case of pseudohomozygous type II hyperlipoproteinemia in early infancy

Inheritable abnormal lipoprotein metabolism in Werner's syndrome similar to familial hypercholesterolaemia

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