Determination by capillary zone electrophoresis of mercaptopurine and thioguanine concentration in capsules for paediatric patients

Abstract

The two antineoplastic agents could be assayed rapidly by the same capillary zone electrophoretic method with acceptable accuracy and precision. This method is suitable for routine control of capsules prepared for paediatric patients.

Determination of 6‐mercaptopurine in the presence of uric acid using modified multiwall carbon nanotubes‐TiO2 as a voltammetric sensor

“…Therefore, the drug has the potential to be cancer‐causing in humans. Various methods including high performance liquid chromatography (HPLC),2–6 capillary electrophoresis,7–10 electrochemical methods,11, 12 fluorescence,13, 14 and spectrophotometric methods15 have been used for the detection of 6‐MP in plasma. Recently, in order to obtain an effective separation and sensitive detection, some coupled methods such as capillary electrophoresis with laser‐induced fluorescence,16 liquid chromatography with electrochemical detection, 17 and liquid chromatography with microdialysis 18 have been used for monitoring 6‐MP.…”

Electrochemical determinations of 6-mercaptopurine on the surface of a carbon nanotube-paste electrode modified with a cobalt salophen complex

“…Numerous analytical methods have been developed for the determination of MP in pharmaceutical and biological preparations including high-performance liquid chromatography [4,5], capillary electrophoresis (CE) [6,7], CE with laser-induced fluorescence [8], capillary zone electrophoresis with amperometric detection at a carbon electrode [9], spectrophotometry [10,11], spectrofluorimetry [12], chemiluminescence [13], flow injection chemiluminescence determination of 6-mercaptopurine based on a new system of potassium permanganate-thioacetamide-sodium hexametaphosphate [14], and an integrated microfluidic device with online labeling and chemiluminescence [15]. Some electrochemical methods, e.g., polarography [16], voltammetric determination at silver microdisk electrodes [17], amperometric detection at a functionalized multi-walled carbon nanotube (MWCNT)-modified electrode in liquid chromatography coupled with microdialysis [18], voltammetric determination using a graphite electrode modified with [Co (phen) 3 ] 3 + /MWCNT [19], determination of 6-mercaptopurine using modified multiwall carbon nanotubes TiO 2 as a voltammetric sensor [20], and cathodic stripping voltammetric determination at a silver electrode [21], have been reported for the determination of MP.…”

Simple Chemiluminescence Method for the Determination of Mercaptopurine

“…5 Georget et al determined MP in capsules prepared for paediatric patients by capillary zone electrophoresis. 6 Chemiluminescence (CL) has been exploited with a wide range of applications in different fields, such as biotechnology, pharmacology, molecular biology, and clinical and environmental chemistries.…”

“…1 Several liquid chromatographic methods have also been described. [2][3][4][5][6] Jonkers et al determined MP in human plasma using HPLC, including post-column derivatization and fluorometric detection. 4 Van Os et al measured MP using solid-phase extraction and reversed-phase HPLC.…”

“…5 Georget et al determined MP in capsules prepared for paediatric patients by capillary zone electrophoresis. 6 Chemiluminescence (CL) has been exploited with a wide range of applications in different fields, such as biotechnology, pharmacology, molecular biology, and clinical and environmental chemistries. [7][8][9][10] However, only one CL method was reported for the determination of MP, which was based on reactions among tris-(2,2′-bipyridine)ruthenium(II), MP, hydrogen peroxide, Tween 20 and hydroxide ion.…”