Determination and understanding of lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements

Peeters, Michiel; Peeters, Elisabeth; Hauwermeiren, Daan Van; Cogoni, Giuseppe; Liu, Yang; Beer, Thomas De

doi:10.1016/j.ijpharm.2021.121328

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…The only study showing the problem with this attribute concern tablets splitting [63]. However, a large number of articles on content uniformity and the ways of continuous monitoring tablet content uniformity [64] suggest that it is a difficult task to achieve.…”

Section: Melatonin Glucosaminementioning

confidence: 99%

Application of Liquid Chromatography Coupled to Mass Spectrometry in Quality Assessment of Dietary Supplements—A Case Study of Tryptophan Supplements: Release Assay, Targeted and Untargeted Studies

Stępień

Giebułtowicz

2022

Pharmaceuticals

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Dietary supplements are widely consumed in the EU and the USA. Based on their similarity to pharmaceuticals, consumers mistakenly believe that dietary supplements have also been approved for safety and efficacy. However, in the absence of mandatory testing, data on supplement quality is scarce. Thus, we applied liquid chromatography coupled with tandem mass spectrometry to analyse the quality of dietary supplements containing tryptophan (Trp). We examined 22 supplements in tablets or capsules, produced in the USA, Great Britain, Germany, France, Czech Republic, and Poland. Trp release, crucial for bioavailability and efficiency, was assessed. Additionally, we performed a qualitative analysis of the main ingredient and screened for contaminants. Among the contaminants, we detected Trp’s metabolites, condensation products of Trp and carbonyl compounds, Trp degradation products, degradation products of kynurenine, and other contaminants such as glucosamine and melatonin. The main ingredient content was in the range of 55–100% in capsules and 69–87% in tablets. Surprisingly, almost no Trp release was noted from some supplements. Our study confirms the need to advance research on supplements. We believe that the high-quality analysis of supplements based on reliable analytical techniques will be an important contribution to the discussion on the regulatory framework of these products.

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Section: Melatonin Glucosaminementioning

confidence: 99%

Application of Liquid Chromatography Coupled to Mass Spectrometry in Quality Assessment of Dietary Supplements—A Case Study of Tryptophan Supplements: Release Assay, Targeted and Untargeted Studies

Stępień

Giebułtowicz

2022

Pharmaceuticals

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“…In continuous manufacturing, the implementation of PAT is part of the control strategy to evaluate and ensure the quality of intermediate or final products to promote Real-Time Release (RTR). In-line PAT measurements are necessary to enable RTR of tablets and have been investigated extensively. − The feed frame of a tablet press can be seen as a critical location for PAT implementation as it is the final mixing element determining blend homogeneity and potency. An NIR or Raman probe can therefore be inserted in the feed frame and steer the tableting process through either feedback (e.g., to the feeders of the tablet press) or feedforward control (through tablet waste diversion).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Improvement of Blend Potency Measurements in the Feed Frame of a Rotary Tablet Press Using Combined NIR and Raman Spectroscopy

De Man,

De Souter,

Shi

et al. 2024

Anal. Chem.

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Application of Convolutional Neural Network Model Based on Combined NIR-Raman Spectra in Feed Composition Analysis

Zhang

Liang

Cheng

et al. 2022

Sense the Real Change: Proceedings of the 20th International Conference on Near Infrared Spectroscopy

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Determination and understanding of lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements

Cited by 6 publications

References 23 publications

Application of Liquid Chromatography Coupled to Mass Spectrometry in Quality Assessment of Dietary Supplements—A Case Study of Tryptophan Supplements: Release Assay, Targeted and Untargeted Studies

Application of Liquid Chromatography Coupled to Mass Spectrometry in Quality Assessment of Dietary Supplements—A Case Study of Tryptophan Supplements: Release Assay, Targeted and Untargeted Studies

Evaluating the Improvement of Blend Potency Measurements in the Feed Frame of a Rotary Tablet Press Using Combined NIR and Raman Spectroscopy

Application of Convolutional Neural Network Model Based on Combined NIR-Raman Spectra in Feed Composition Analysis

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