Determination and Quantification of the Distribution of CN-NL Nanoparticles Encapsulating Glycyrrhetic Acid on Novel Textile Surfaces with Hyperspectral Imaging

Obisesan, Kudirat Abidemi; Neri, Simona; Bugnicourt, Elodie; Campos, Inmaculada; Rodríguez-Turienzo, Laura

doi:10.3390/jfb11020032

Cited by 9 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, on the nanoscale, chitin is able to modulate the pro- and anti-inflammatory reaction of dermal keratinocytes [ 1 , 25 ]. The application of an easy and efficient method for decorating the biomaterial surfaces with such components and for quality control of the outcomes has been the subject of recent studies [ 26 ]. Water-based spray of CNs may affect the cellulose substrate surface by wetting.…”

Section: Discussionmentioning

confidence: 99%

Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application

et al. 2021

View full text Add to dashboard Cite

Cosmetics has recently focused on biobased skin-compatible materials. Materials from natural sources can be used to produce more sustainable skin contact products with enhanced bioactivity. Surface functionalization using natural-based nano/microparticles is thus a subject of study, aimed at better understanding the skin compatibility of many biopolymers also deriving from biowaste. This research investigated electrospray as a method for surface modification of cellulose tissues with chitin nanofibrils (CNs) using two different sources—namely, vegetable (i.e., from fungi), and animal (from crustaceans)—and different solvent systems to obtain a biobased and skin-compatible product. The surface of cellulose tissues was uniformly decorated with electrosprayed CNs. Biological analysis revealed that all treated samples were suitable for skin applications since human dermal keratinocytes (i.e., HaCaT cells) successfully adhered to the processed tissues and were viable after being in contact with released substances in culture media. These results indicate that the use of solvents did not affect the final cytocompatibility due to their effective evaporation during the electrospray process. Such treatments did not also affect the characteristics of cellulose; in addition, they showed promising anti-inflammatory and indirect antimicrobial activity toward dermal keratinocytes in vitro. Specifically, cellulosic substrates decorated with nanochitins from shrimp showed strong immunomodulatory activity by first upregulating then downregulating the pro-inflammatory cytokines, whereas nanochitins from mushrooms displayed an overall anti-inflammatory activity via a slight decrement of the pro-inflammatory cytokines and increment of the anti-inflammatory marker. Electrospray could represent a green method for surface modification of sustainable and biofunctional skincare products.

show abstract

Section: Discussionmentioning

confidence: 99%

Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application

et al. 2021

View full text Add to dashboard Cite

show abstract

“…CNs and CLA complexes are bio-based nano- and micro-compounds that can be considered useful bioactive agents for functionalizing skin contact substrates, as they showed proficient interaction in an in vitro skin model [ 14 ]. It is important to obtain an easy and effective method for applying such components to biomaterial surfaces to put in contact with skin, encompassing bulk incorporation and surface functionalization [ 15 , 28 ]. In fact, if plain CNs are applied as water suspension, further steps like evaporation must be taken into account.…”

Section: Discussionmentioning

confidence: 99%

“…Such complexes have demonstrated the ability to incorporate biomolecules such as the glycyrrhetinic acid (GA), which is derived from the licorice plant and possesses anti-inflammatory and antimicrobial properties that are interesting for treating skin disorders [ 13 ]. CN-NL/GA (CLA) complexes were developed by spray dry technology in previous studies and showed promise for skin contact applications, as CN-NL provides a suitable carrier to promote GA delivery [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Chitin Nanofibril/Electrospun Polyhydroxyalkanoate Fiber Mesh as Functional Nonwoven for Skin Application

Azimi

Thomas

Fusco

et al. 2020

JFB

View full text Add to dashboard Cite

Polyhydroxyalkanoates (PHAs) are a family of bio-based polyesters that have found different biomedical applications. Chitin and lignin, byproducts of fishery and plant biomass, show antimicrobial and anti-inflammatory activity on the nanoscale. Due to their polarities, chitin nanofibril (CN) and nanolignin (NL) can be assembled into micro-complexes, which can be loaded with bioactive factors, such as the glycyrrhetinic acid (GA) and CN-NL/GA (CLA) complexes, and can be used to decorate polymer surfaces. This study aims to develop completely bio-based and bioactive meshes intended for wound healing. Poly(3-hydroxybutyrate)/Poly(3-hydroxyoctanoate-co-3-hydroxydecanoate), P(3HB)/P(3HO-co-3HD) was used to produce films and fiber meshes, to be surface-modified via electrospraying of CN or CLA to reach a uniform distribution. P(3HB)/P(3HO-co-3HD) fibers with desirable size and morphology were successfully prepared and functionalized with CN and CLA using electrospinning and tested in vitro with human keratinocytes. The presence of CN and CLA improved the indirect antimicrobial and anti-inflammatory activity of the electrospun fiber meshes by downregulating the expression of the most important pro-inflammatory cytokines and upregulating human defensin 2 expression. This natural and eco-sustainable mesh is promising in wound healing applications.

show abstract

“…Therefore chitin, when used at nano dimension, encourages the skin regeneration activity probably because its nanofibrils provide a three-dimensional structure that mimics the natural extracellular matrix (ECM) (Figure 7) [90]. Moreover and first of all, the different polymers and active ingredients have to be well selected, according to their therapeutic or cosmetic applications (Figure 8) [91,92]. Just as an example, our research group has encapsulated glycyrrhetinic acid (GA) as antiinflammatory agent and vitamin E as antioxidant compound into the complex chitin nanofibrils and nanolignin (CN-LG), verifying their distribution on the novel textile surface and the Vit E recovery (Figure 9) [93,94].…”

Section: Biofunctional Textiles and Nanocomposites For Medical And Cosmetic Usementioning

confidence: 99%

Food Loss and Food Waste for Green Cosmetics and Medical Devices for a Cleaner Planet

et al. 2022

View full text Add to dashboard Cite

To stay wealthy in a world where all can live in prosperity and wellbeing, it is necessary to develop sustainable growth at net zero emissions to stop climate change, neutralizing both risks and diseases such as the COVID-19 pandemic and inequalities. Changing the worldwide use of the great quantity of food loss and waste can help to move in this direction. At this purpose, it seems useful to transform food waste into richness, extracting and using its content in natural ingredients and biopolymers to make new sustainable products and goods, including cosmetics and medical devices. Many of these ingredients are not only bioactive molecules considered of interest to produce these consumer products but are also useful in reducing the environmental footprint. The active agents may be obtained, for example, from waste material such as grapes or olive pomace, which include, among others natural polymers, phythosterols, vitamins, minerals and unsaturated fatty acids. Among the polymers, chitin and lignin have shown particular interest because biodegradable, nontoxic, skin- and environmentally friendly ingredients can be obtained at low cost from food and forestry waste, respectively. According to our experience, these polymers may be used to make nanocomposites and micro-nanoparticles that encapsulate different active ingredients, and which may be embedded into gel and non-woven tissues to realize advanced medications and smart cosmeceuticals. However, to utilize food waste in the best possible way, a better education of both industry and the consumer is considered necessary, introducing all to change the ways of production and living. The consumer has to understand the need to privilege, food, cosmetics and goods by selecting products known to be effective that also have a low release of carbon dioxide. Thus, they must pay heed to purchasing cosmetics and medical devices made by natural ingredients and packaged by biodegradable and/or reusable containers that are possibly plastic free. Conversely, the industry must try to use natural raw materials obtained from waste by changing their actual production methods. Therefore, both industry and the consumer should depart from the linear economy, which is based on taking, making, and producing waste, to move into a circular economy, which is based on redesigning, reducing, reusing and recycling. Some examples will report on the possibility to use natural polymers, including chitin and lignin, to produce new cosmeceutical tissues. These innovative tissues, to be used as biodegradable carriers for making smart cosmetics and medical devices, may be produced at zero waste to save our health and the planet biodiversity.

show abstract

Determination and Quantification of the Distribution of CN-NL Nanoparticles Encapsulating Glycyrrhetic Acid on Novel Textile Surfaces with Hyperspectral Imaging

Cited by 9 publications

References 23 publications

Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application

Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application

Electrosprayed Chitin Nanofibril/Electrospun Polyhydroxyalkanoate Fiber Mesh as Functional Nonwoven for Skin Application

Food Loss and Food Waste for Green Cosmetics and Medical Devices for a Cleaner Planet

Contact Info

Product

Resources

About