Determination and analysis of the full-length chicken parvovirus genome

Day, J. Michael; Zsák, László

doi:10.1016/j.virol.2009.12.027

Cited by 53 publications

(50 citation statements)

References 38 publications

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“…The ChPV and TuPV are relatively newly identified viruses, and the full genome was determined only recently (Day & Zsak, 2010). There are few data in the literature regarding the definite correlation between virus presence and disease.…”

Section: Discussionmentioning

confidence: 99%

“…Morbidity and mortality are variable, and the economic impact is primarily due to poor production, failure of affected birds to grow, as well as increased costs of therapy, and poor feed conversion efficiency; but in the severe forms, immune dysfunction and increased mortality have been reported (Day & Zsak, 2010). Viruses from numerous families have been identified in the intestinal tracts of poultry with ED: Astroviridae, Coronaviridae, Reoviridae, Rotaviridae (Pass et al, 1982;Reynolds et al, 1987a, b;Goodwin et al, 1993;Guy, 1998;Koci et al, 2000;Yu et al, 2000;Spackman et al, 2005;Pantin-Jackwood et al, 2007a, b, 2008bDay et al, 2007a, b;Jones, 2008;Reynolds & Shultz-Cherry, 2008), and Parvoviridae (Kisary et al, 1984(Kisary et al, , 1987Woolcock & Shivaprasad, 2008;Zsak et al, 2008Zsak et al, , 2009Day & Zsak, 2010). The role of these viruses in the ED is not fully understood (Zsak et al, 2008), but is supported by the syndrome reproducibility with preparations from the intestinal contents of affected birds, which do not contain bacteria or protozoa (Barnes & Guy, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…The following molecular biological studies revealed that the virus belongs to the Parvoviridae family (Kisary et al, 1985). The full genome of the newly involved virus was recently determined and analysed (Day & Zsak, 2010). Parvoviruses have a linear single-stranded DNA, between 4 and 6 kilobase pairs; they are non-enveloped, icosahedral virions of approximately 20 nm in diameter (Tattersall, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Naturally occurring parvoviral infection in Hungarian broiler flocks

Palade

Kisary²,

Benyeda

et al. 2011

Avian Pathology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Naturally occurring parvoviral infection in Hungarian broiler flocks

Palade

Kisary²,

Benyeda

et al. 2011

Avian Pathology

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“…This reflects a major jump in known virus diversity, with many new species and genera first identified in clinical or veterinary samples using PCR-based virus discovery methods (Allander et al 2005;Jones et al 2005;Day and Zsak 2010). Potential human pathogens that are still pending recognition include genetic variants of Human Bocavirus (HBoV 1 -4), which are particularly common in the respiratory and gastrointestinal tracts of children (Kapoor et al 2010;Kantola et al 2011), and two broadly distributed genotypes of a "PARV4"-based genus (the aforementioned Partetraviruses), parenterally transmitted among injecting drug users, hemophiliacs, and polytransfused individuals (Sharp et al 2009;Lahtinen et al 2011).…”

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confidence: 99%

Parvovirus Diversity and DNA Damage Responses

Cotmore

Tattersall

2013

Cold Spring Harbor Perspectives in Biology

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Parvoviruses have a linear single-stranded DNA genome, around 5 kb in length, with short imperfect terminal palindromes that fold back on themselves to form duplex hairpin telomeres. These contain most of the cis-acting information required for viral "rolling hairpin" DNA replication, an evolutionary adaptation of rolling-circle synthesis in which the hairpins create duplex replication origins, prime complementary strand synthesis, and act as hinges to reverse the direction of the unidirectional cellular fork. Genomes are packaged vectorially into small, rugged protein capsids 260 Å in diameter, which mediate their delivery directly into the cell nucleus, where they await their host cell's entry into S phase under its own cell cycle control. Here we focus on genus-specific variations in genome structure and replication, and review host cell responses that modulate the nuclear environment.V iruses from the family Parvoviridae are unique in having a linear single-stranded DNA genome, 5 kb in length, which terminates in short (120 -420 base) imperfect palindromes that fold into self-priming hairpin telomeres. These viruses replicate via a "rolling hairpin" mechanism, with strong evolutionary and mechanistic links to "rolling-circle" replication, as reviewed in detail in previous editions of this work Tattersall 1996, 2006). Rolling hairpin synthesis relies on the ability of each hairpin to give rise to a duplex origin sequence, which can be nicked by a viral initiator nuclease to create a base-paired DNA primer, and to function as a hinge, allowing quasi-circular synthesis by alternately folding and unfolding to shuttle a continuous unidirectional replication fork back and forth along linear DNA. Together with a few adjacent nucleotides, these palindromes provide all of the cis-acting information required for viral DNA replication and packaging. However, the size, sequence, and predicted structures of the hairpins can vary substantially between genera, or even between the two ends of a single genome, and they appear to have adapted to fulfill multiple additional roles in the life cycle of specific viruses. Parvoviral DNA amplification proceeds via a unidirectional single-strand displacement mechanism through a series of monomeric and concatemeric duplex replicative-form (RF) intermediates, and while the viral initiator protein, variously called NS1 or Rep, serves both as a siteand strand-specific nickase and as a 3 0 -to-5 0 helicase, all other replicative functions are co-opted from the host cell. This mechanism benefits from

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“…Nucleotide sequences were obtained from VP1/VP2 nPCR assay amplicons and compared to sequences already available in GenBank (6). Intrasample variability ranging from 96.4 to 100% was observed by cloning one of the amplicons obtained and studying the sequences of 9 clones.…”

mentioning

confidence: 99%