“…We selected variables pertaining to the following groups: (1) depressive symptoms and characteristics of periods of depression; (2) anxiety symptoms and characteristics of periods of anxiety; (3) neuroticism-related personality traits; (4) physical diseases and lifestyle; (5) PRSs of psychiatric disorders [MDD, schizophrenia, bipolar disorder, attention-deficit hyperactivity disorder (ADHD), alcohol dependence, anxiety disorders] and neuroticism. These were selected because they represent domains or genetic factors previously associated with the course, functional impact or treatment outcomes of MDD and/or wellbeing in the general population (Bartova et al, 2019; Cho et al, 2019; Christensen et al, 2020; Fabbri et al, 2021; Fanelli et al, 2021; Helliwell, 2019; McIntyre et al, 2013; Pain et al, in press; Santini et al, 2020; Spittlehouse et al, 2014; Stranges et al, 2014). For the selection of PRSs to include in the study, we also considered the availability of summary statistics from genome-wide association studies without sample overlap with UKB, to avoid overfitting (Choi, Mak, & O'Reilly, 2020).…”