Determinants of Thyroid Volume as Measured by Ultrasonography in Healthy Adults in a Non‐iodine Deficient Area

Berghout, A; Wiersinga, Wilmar M.; Smits, N. J.; Touber, J. L.

doi:10.1111/j.1365-2265.1987.tb00784.x

Cited by 175 publications

(133 citation statements)

References 18 publications

(15 reference statements)

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…An inverse relationship between thyroid volume and urinary iodine excretion has also been reported in European schoolchildren (Delange et al, 1997), but not in German adults where the range of marginal iodine status was narrow (Gutekunst et al, 1986), or in Dutch adults where iodine status was adequate (Berghout et al, 1987). Our study appears to be the ®rst to report an inverse relationship between urinary iodide excretion and serum thyroglobulin.…”

Section: Discussionsupporting

confidence: 61%

Urinary iodine and thyroid status of New Zealand residents

et al. 2001

View full text Add to dashboard Cite

Objectives: The aim of this project was to assess the clinical signi®cance of our low iodine excretions in terms of thyroid hormone status and thyroid volume in an adult population in a low soil iodine area of the South Island of New Zealand. Design and setting: Two-hundred and thirty-three residents of Otago, New Zealand collected two 24 h urine samples for assessment of iodine status. Thyroid status was determined from serum total T 4 , TSH and thyroglobulin, and thyroid volumes. Relationships between urinary iodide excretion and measures of thyroid status were determined and subjects were allocated to one of three groups according to low, medium and high iodide excretion, for comparison of thyroid hormones and thyroid volumes. Results: Signi®cant correlations were found for relationships between measures of urinary iodide excretion and thyroid volume and thyroglobulin. Multiple regression analysis of data for subjects divided into three groups according to 24 h urinary iodide excretion (`60, 60 ± 90; b90 mg iodideaday) or iodideacreatinine ratio (`40; 40 ± 60; b60 mgag Cr) showed signi®cant differences in thyroid volume (P 0.029; P 0.035, respectively) and thyroglobulin (P 0.019; P 0.005, respectively) among the groups. Conclusions: The results of this study con®rm the low iodide excretions of Otago residents, and indicate that the fall in iodine status is being re¯ected in clinical measures of thyroid status, including enlarged thyroid glands and elevated thyroglobulin. Our observations suggest the possible re-emergence of mild iodine de®ciency and goitres in New Zealand. This situation is likely to worsen should iodine intakes continue to fall and continued monitoring of the situation is imperative.

show abstract

Section: Discussionsupporting

confidence: 61%

Urinary iodine and thyroid status of New Zealand residents

et al. 2001

View full text Add to dashboard Cite

show abstract

“…US measurement of thyroid volume is used in diagnosis and followup of patients, and normal US thyroid volumes in adult and pediatric age groups are published in many references and may be used as a guide to decide whether the thyroid size is normal or not (11)(12)(13)(14)(15). However, to our knowledge, no study has been performed to determine the interobserver and intraobserver variation in US measurement of thyroid volume in children.…”

Section: Discussionmentioning

confidence: 74%

“…This method is also used to determine thyroid size in both diagnosis and follow-up of patients with diseases that could affect the thyroid gland (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Normal ranges of thyroid volumes in pediatric age groups and adults have been published in many references, and may be a guide to decide whether thyroid size is normal or not (11)(12)(13)(14)(15). The aim of this study was to determine the interobserver and intraobserver variation in US measurement of thyroid volume in children.…”

Section: Introductionmentioning

confidence: 99%

Interobserver and intraobserver variations in sonographic measurement of thyroid volume in children

Özgen

Erol

Kaya

et al. 1999

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To determine the interobserver and intraobserver variations in sonographic measurement of thyroid volume in children. Design: Thyroid volumes of 30 healthy children were measured by three separate observers. Additionally each observer measured thyroid volumes of ten separate children three times. Methods: The data were used to assess intraobserver and interobserver variations in measurement of thyroid volume. Interobserver and intraobserver variations in measuring each diameter of the thyroid gland were also determined. The effect of thyroid size on interobserver and intraobserver variations was analyzed. Results: Intraobserver variation in measurement of thyroid volume was 8.4 Ϯ 6.7% (mean Ϯ S.D.). Interobserver variation was 13.3 Ϯ 8.2%. The widest interobserver variation was encountered in determining the craniocaudal diameter of the thyroid gland. No correlation was found between thyroid volume and interobserver variation (r = ¹0.12, P = 0.27), whereas a slight but statistically significant correlation was found between thyroid volume and intraobserver variation (r = ¹0.26, P = 0.012). Conclusion: Significant interobserver and intraobserver variation occurs in sonographic measurement of thyroid volume in children.

show abstract

“…Nodules and cystic areas were included in thyroid volume determination, whereas the isthmus was not taken into account in volume calculations. This method has been proven to be very accurate (22). Goiter was defined as an enlarged thyroid volume exceeding 25 mL in males and 18 mL in females (23).…”

Section: Thyroid Ultrasonography (1995-1996)mentioning

confidence: 99%

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

Estaquio

Valeix²,

Leenhardt³

et al. 2009

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

Background: The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thyroxine (fT 4 ) based on data collected from a diseasefree sample of French middle-aged adults. Methods: A total of 3218 subjects participating in the Supplé mentation en Vitamines et Miné raux Antioxydants (SU.VI.MAX) study had measurements for TSH, fT 4 and urinary iodine concentrations. Thyroid volume and structure were evaluated using standardized ultrasonography. We selected a disease-free sample which included 2338 subjects (1313 females aged 35-60 years and 1025 males aged 45-60 years) with normal thyroid imaging, no previously reported thyroid disease or use of thyroid medication, and no risk factors for thyroid dysfunction. Distribution of TSH and fT 4 was estimated in males and females. Results: The median (central 95% range) TSH serum concentrations for females were 1.79 mU/L (0.29-5.21 mU/L) for ages 35-44 years and 1.98 mU/L (0.27-6.94 mU/L) for ages 45-60 years (p-0.0001, for age). The median (central 95% range) for males

show abstract

Determinants of Thyroid Volume as Measured by Ultrasonography in Healthy Adults in a Non‐iodine Deficient Area

Cited by 175 publications

References 18 publications

Urinary iodine and thyroid status of New Zealand residents

Urinary iodine and thyroid status of New Zealand residents

Interobserver and intraobserver variations in sonographic measurement of thyroid volume in children

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

Contact Info

Product

Resources

About