Many dimensions of urban sustainability are intricately intertwined; however, systematic assessment of those linkages is often missing. To explore the details of these interdisciplinary linkages, we employ an in-depth literature review technique coupled with a multidimensional assessment of sustainability for 1300+ cities and regions in Europe. The wealth of indicators affecting economic, smart, social and environmental dimensions are linked within a coherent framework illustrating systemic links in urban sustainability. The performance of cities is illustrated using the multidimensional framework highlighting the contributions of various factors. The spectacular performance of Stockholm, Paris, London, Gothenburg, Malmö, Munich and Hamburg are illustrated with examples. Policy recommendations are offered to make cities and regions around the world more sustainable.