Determinants of telomere length across human tissues

Demanelis, Kathryn; Jasmine, Farzana; Chen, Lin S.; Chernoff, Meytal; Lin, Tong; Delgado, Dayana; Zhang, Chenan; Shinkle, Justin; Sabarinathan, Mekala; Lin, Hannah; Ramirez, Eduardo; Oliva, Meritxell; Kim-Hellmuth, Sarah; Stranger, Barbara Elaine; Lai, Tsung‐Po; Aviv, Abraham; Ardlie, Kristin; Aguet, François; Ahsan, Habibul; Doherty, Jennifer A.; Kibriya, Muhammad G.; Pierce, Brandon L.

doi:10.1126/science.aaz6876

Cited by 271 publications

(154 citation statements)

References 69 publications

Supporting

Mentioning

151

Contrasting

Order By: Relevance

“…These results, however, could be confounded by the small sample size and also by the variable health status of donors. Convincing evidence supporting differences in TL amongst human tissues has been provided in a more recent research by Demanelis et al (2020). In this large-scale study, rTL has been measured during the Genotype-Tissue Expression (GTEx) project in more than 25 tissue types from 952 deceased donors (age from 20 to 70).…”

Section: Analytical Aspectsmentioning

confidence: 92%

“…Therefore, TL is suggested to limit the cell division number and acts as a "mitotic clock" in the cell (Olovnikov, 1996), and telomere shortening may cause decreasing of proliferative potential and be a marker for cellular senescence (Liu et al, 2019a). In a multicellular organism, TLs are highly heterogeneous across different tissues and cell types depending, at least partly, on the tissue-specific proliferation rate, but they generally tend to decrease with age in all proliferating tissues (Demanelis et al, 2020).…”

Section: Basic Principles Of Telomere Biologymentioning

confidence: 99%

“…In addition, components of telomerase have been found to be more highly expressed in testis than in any other tissue. For schematic representation of the main findings from the study by Demanelis et al (2020), see Figure 8.…”

Section: Analytical Aspectsmentioning

confidence: 99%

See 2 more Smart Citations

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

2021

View full text Add to dashboard Cite

Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common feature of age-related diseases. Therefore, telomere length (TL) has been recognized for a long time as one of the best biomarkers of aging. Recent research findings, however, indicate that TL per se can only allow a rough estimate of aging rate and can hardly be regarded as a clinically important risk marker for age-related pathologies and mortality. Evidence is obtained that other indicators such as certain immune parameters, indices of epigenetic age, etc., could be stronger predictors of the health status and the risk of chronic disease. However, despite these issues and limitations, TL remains to be very informative marker in accessing the biological age when used along with other markers such as indices of homeostatic dysregulation, frailty index, epigenetic clock, etc. This review article is aimed at describing the current state of the art in the field and at discussing recent research findings and divergent viewpoints regarding the usefulness of leukocyte TL for estimating the human biological age.

show abstract

Section: Analytical Aspectsmentioning

confidence: 92%

Section: Basic Principles Of Telomere Biologymentioning

confidence: 99%

See 1 more Smart Citation

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

2021

View full text Add to dashboard Cite

show abstract

“…Recently, an extensive analysis of telomere length (TL) in different human tissues types and individuals clearly showed a significant correlation of TL with genetic background, gene expression and ageing. Furthermore, this analysis clearly showed that telomere shortening mediates aging related gene expression [14]. For longtime telomeres have been considered as silent chromatin territories.…”

Section: Telomeres Structure and Functionmentioning

confidence: 72%

An Update of Molecular Basis of Telomere Biology Diseases

Vertecchi¹,

Iuzzolino²,

Salvati³

2021

Preprint

View full text Add to dashboard Cite

Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. In a classic view, telomere biology impinges on intracellular signaling pathways regulating DNA damage repair and cell cycle arrest, but new roles of telomeric proteins and transcripts emerge from recent literature. Telomere biology diseases are human disorders associated to telomere attrition. This review wants to overview the recent findings in the field of telomere’s metabolism and to deepen molecular mechanisms of inherited and acquired telomeropathies, explaining new critical connections between telomeric factors and disease pathogenesis

show abstract

“…Many clinical biomarker studies have focused on TL in whole blood mostly because of the ease of collection as well as low invasiveness, allowing for the repeated collection of samples. Furthermore, accumulating evidence suggests that TL correlates positively across tissue types (22,23). Specifically, Daniali and colleagues showed that telomeres in leukocytes and SAT are highly correlated and that they shorten at a similar rate (23).…”

Section: Epidemiology/geneticsmentioning

confidence: 99%

Correlation of Telomere Length in Adipose Tissue and Leukocytes and its Association with Postsurgical Weight Loss

Gurung

Yiamunaa

Moh

et al. 2020

Obesity

View full text Add to dashboard Cite

ObjectiveThe aim of this study was to determine the relationship between telomere length (TL) in subcutaneous adipose tissue (SAT), visceral adipose tissues (VAT), and leukocytes, as well as to examine the associations of TL in these tissues with postsurgical weight loss in Asians with severe obesity.MethodsPresurgery TL was measured in leukocytes, SAT, and VAT of 91 patients who underwent weight loss surgery. Correlation between TL in multiple tissues was assessed using Pearson correlation. The association of presurgery TL and postsurgical weight loss at 6 or 12 months, expressed as a percentage of weight loss, was determined using linear regression in 70 patients.ResultsTelomeres were longer in VAT compared with those in leukocytes and SAT (P < 0.001) but were highly correlated between tissues. The strongest correlation was observed between TL in VAT and leukocytes (r = 0.739, P = 6.22 × 10−17). Compared with individuals in the highest tertile, those in the lowest tertile of VAT TL showed greater weight loss (β = 6.23, SE = 3.10, P = 0.044) independent of age, sex, ethnicity, types of surgery, diabetes condition, preoperative BMI, and follow‐up period.ConclusionsAmong patients with severe obesity, TL in leukocytes and adipose tissue was highly correlated. However, there was variability in the association of TL in these tissues with weight loss after surgery.

show abstract

Determinants of telomere length across human tissues

Cited by 271 publications

References 69 publications

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

An Update of Molecular Basis of Telomere Biology Diseases

Correlation of Telomere Length in Adipose Tissue and Leukocytes and its Association with Postsurgical Weight Loss

Contact Info

Product

Resources

About