Determinants of survival in AIDS patients on antiretroviral therapy in a rural centre in the Far‐North Province, Cameroon

Sieleunou, Isidore; Souleymanou, Mohamadou; Schönenberger, Anne-Marie; Menten, Joris; Boelaert, Marleen

doi:10.1111/j.1365-3156.2008.02183.x

Cited by 102 publications

(126 citation statements)

References 42 publications

(82 reference statements)

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“…The frequency of thinness found in the present study (8.8%) differs from that found by Sieleunou et al 35 . The low prevalence of underweight individuals in the study population may be due to the fact that most of the subjects studied were receiving HAART and had good immune control.…”

Section: Discussioncontrasting

confidence: 99%

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Body mass index in individuals with HIV infection and factors associated with thinness and overweight/obesity

et al. 2011

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A cross-sectional study was conducted using body mass index (BMI) to estimate the prevalence of thinness and overweight/obesity and associated factors in 2,018 individuals with HIV/AIDS attending health services referral centers. The dependent variable was classified as thinness, overweight/obesity and eutrophy. Multinomial logistic regression analyses were performed considering eutrophy as the reference level. The prevalence of thinness was 8.8% and of overweight/obesity, 32.1%. The variables associated with thinness were anemia and CD4 cell count < 200mm³. The variables associated with risk of overweight/obesity were age > 40 years and diabetes, and the variables identified as decreasing likelihood of overweight/obesity were having no long-term partner, smoking, presence of an opportunistic disease, anemia, and albumin levels < 3.5mg/dL. The main nutritional problem observed in this population was overweight and obesity, which were much more prevalent than thinness. Older individuals with diabetes should be targeted for nutritional interventions and lifestyle changes.

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Section: Discussioncontrasting

confidence: 99%

“…Recently, Sieleunou et al 35 studied a population of 2161 HIVpositive individuals on HAART living in Cameroon, and found a percentage of 56% of thinness.…”

Section: Discussionmentioning

confidence: 99%

Body mass index in individuals with HIV infection and factors associated with thinness and overweight/obesity

et al. 2011

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“…This finding largely deviated from the finding of other studies in Tanzania [8] and Cameroon [4]. Along with other methodological and study set up differences, the sample size, the longer follow-up period, time of ART initiation and treatment change may enlarge the difference of survival probability.…”

Section: Discussioncontrasting

confidence: 83%

“…Recommendations are made for further expansion and sustainability of the ART scale-ups [3]. The clinical benefit of ART for AIDS patients, in terms of mortality reduction and improved quality of life, is well established but shows regional variations, with higher case fatality rates in poor countries [4].…”

Section: Introductionmentioning

confidence: 99%

Survival and Predictors of Mortality among Adults on Antiretroviral Therapy in Selected Public Hospitals in Harar, Eastern Ethiopia

Digaffe¹,

Seyoum²,

Oljirra³

2014

J Trop Dis

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“…Below these values for HIV positive patients are signs for requiring ARVs. The U.S. Department of Health and Human Services (HHS) provides guidelines on using ARVs and other HIV medicines to treat HIV infection (Sieleunou and Souleymanou, 2009 (Lichterfeld and Rosenberg, 2011). A CD4 increase is a sign of immune system recovery.…”

Section: Hiv Treatment and Healthmentioning

confidence: 99%

A New Proposed Statistically-Derived Compromise Cut-off CD4 Count Value for HIV Patients to Start using ARVs

Lekganyane¹,

Seeletse²

2016

American Journal of Applied Sciences

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Abstract:The study investigated the relationship between statistical outliers and the inconsistent values of the CD4 count recommended for starting the Antiretroviral Therapy (ART) by HIV-positive patients. Low CD4 counts imply a low immune system. It could be due to AIDS existence or closeness to death. An effective treatment to curb HIV impact is ART, which is recommended for low CD4 counts. However, countries differ in the values used. Developed nations recommend start of ART when the CD4 is still high in order to curb its development. Poor countries use very low CD4 counts. Some countries keep changing the CD4 value for this purpose. The problem is that when CD4 counts are too low, HIV may already be too advanced, making it difficult to save the patient from progression to full AIDS. There should be CD4 values derived using scientific methods to assist in standardizing the CD4 count value for ART commencement. Using a retrospective single-site cohort study design, the study analyses the CD4 counts using robust statistical methods together with conventional statistical methods to study outliers and then derive a compromise CD4 count value that could serve as the standard cut-off starting point for using ART. The CD4 count confidence limits showed outliers to be above 300 cells/mm 3 . The lower bound of 0 cannot happen to any living person. The 300 upper bound is a value within the manageable outliers that has not reached critical HIV state. However, this value is near risky CD4 count values. The CD4 count of 300cells/mm 3 indicates deteriorating HIV. If it is set as the starting point of taking ARVs, the patients involved can be saved from reaching painful states of lower CD4 counts.HIV patients' immune systems at this level can still be boosted without them showing physical weakness from eye inspection.

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Determinants of survival in AIDS patients on antiretroviral therapy in a rural centre in the Far‐North Province, Cameroon

Cited by 102 publications

References 42 publications

Body mass index in individuals with HIV infection and factors associated with thinness and overweight/obesity

Body mass index in individuals with HIV infection and factors associated with thinness and overweight/obesity

Survival and Predictors of Mortality among Adults on Antiretroviral Therapy in Selected Public Hospitals in Harar, Eastern Ethiopia

A New Proposed Statistically-Derived Compromise Cut-off CD4 Count Value for HIV Patients to Start using ARVs

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