Introduction: Videolaryngoscopy (VL) has become a popular method of intubation (ETI). Although VL may facilitate ETI in less-experienced rescuers there are limited data available concerning ETI performed by paramedics during CPR. The goal was to show the benefit of VL during CPR performed by non-physicians in a single emergency department in Germany. We investigated in an observational prospective study the superiority of VL for less-experienced paramedics during CPR compared with direct laryngoscopy (DL).Methods: We instructed and equipped paramedics from four ambulances in endotracheal intubation (ETI) with GlideScope® (GVL). The primary endpoint was good visibility of the glottis (Cormack-Lehane grading 1/2), and the secondary endpoint was successful intubation.Results: In total n = 97 patients were included, n = 69 using DL (with n = 85 intubation attempts) and n = 28 using VL (with n = 37 intubation attempts). Videolaryngoscopy resulted in a significantly improved visualization of the larynx compared with DL. In the group using GVL, 82% rated visualization of the glottis as CL 1&2 versus 55% in the DL group (p = 0.02). Despite better visualization of the larynx, there was no statistically significant difference in successful ETI between GVL and DL (GVL 75% vs. DL 68.1%, p = 0.63).Conclusions: When used by paramedics during CPR, GVL led to better visibility of the glottis but did not increase the number of successful initial intubation attempts. Therefore, we conclude that education in VL should also focus on insertion of the endotracheal tube, considering the different procedures of GVL.