Determinants of subject compliance within an experimental anti-HIV drug protocol

Morse, Edward; Simon, Patricia; Coburn, Mary B.; Hyslop, Newton; Greenspan, D.; Balson, Paul M.

doi:10.1016/0277-9536(91)90093-r

Cited by 106 publications

(96 citation statements)

References 13 publications

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“…Similar to other studies elsewhere 17,[20][21][22] age, sex, marital status, education level and employment status were not affecting adherence to treatment. However higher education status was reported to be better adherence to treatment.…”

Section: Discussionsupporting

confidence: 72%

Adherence to Anti-Retroviral Therapy among People Living with HIV and AIDS in Far West, Nepal

Bam¹,

Karki²,

Lohani³

et al. 2011

Asian J Med Sci

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Objective: Adherence to Anti-Retroviral Therapy is a principal predictor for the success of Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) treatment. It remains as a challenge to AIDS treatment and care with the wide spread of the associated risks. The study aims to assess adherence level and factors associated with adherence to Anti-Retroviral Therapy (ART) among people living with HIV and AIDS in Far West, Nepal. Material & Methods:A cross sectional study was carried out in Far West between May 2009 to September 2009. A total of 176 samples allowed with 95% CI and 5% error proportionately from four ART sites were drawn. Random sampling technique was used to recruit patients. Semi-structured questionnaire schedule adapted from the Adult AIDS Clinical Trials Group (AACTG) was used and pre-tested to collect data on drug adherence. We compared non-adherent patients with adherent patients and associations with key risk factors were determined.

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Section: Discussionsupporting

confidence: 72%

Adherence to Anti-Retroviral Therapy among People Living with HIV and AIDS in Far West, Nepal

Bam¹,

Karki²,

Lohani³

et al. 2011

Asian J Med Sci

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“…Increased numbers of antiretroviral drugs used in the treatment regimens is expected to make it more difficult for the patient to follow the prescription. A majority of trials confirm this hypothesis [16,[18][19][20][21][23][24][25]. However, there was no evidence of such an effect in other studies [7,[11][12][13]22,[26][27][28].…”

supporting

confidence: 60%

Characteristics of HIV antiretroviral regimen and treatment adherence

Silveira¹,

Drachler²,

Leite³

et al. 2003

Braz J Infect Dis

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The relationship between characteristics of HIV antiretroviral regimens and treatment adherence was studied in adolescent and adult patients who underwent antiretroviral therapy from January 1998 to September 2000, at the Service for Specialized Assistance in Pelotas. The patients were interviewed on two occasions, and the use of antiretrovirals during the previous 48 hours was investigated by a self-report. Adherence was defined as use of 95% or more of the prescribed medication. Social-demographic variables were collected through direct questionnaires. The antiretroviral regimen and clinical data were copied from the patients' records. Associations between the independent variables and adherence were analyzed by means of logistic regression. The multivariate analysis included characteristics of the antiretroviral regimens, socialdemographic variables, as well as perception of negative effects, negative physiological states, and adverse effects of the treatment. Among the 224 selected patients, 194 participated in our study. Their ages varied from 17 to 67 years; most patients were men, with few years of schooling and a low family income. Only 49% adhered to the treatment. Adherence to treatment regimens was reduced when more daily doses were indicated: three to four doses (odds ratio of adherence to treatment (OR)=0.47, 95% confidence interval (CI) 0.22-1.01) and five to six (OR=0.24, 95% CI 0.09-0.62); two or more doses taken in a fasting state (OR=0.59, 95% CI 0.11-0.68), and for patients who reported adverse effects to the treatment (OR=0.39, 95% CI 0.19-0.77). Most of the regimens with more than two daily doses of medication included at least one dose apart from mealtimes. The results suggest that, if possible, regimens with a reduced number of doses should be chosen, with no compulsory fasting, and with few adverse effects. Strategies to minimize these effects should be discussed with the patients.

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“…Being married was associated with better adherence indicating that support by the partner may help the individual remember to take the medication. Indeed, Morse et al [23] in a study among HIV patients in the USA showed that living with someone else was associated with improved adherence rates. Also, the analysis showed that lower income is associated with primary non-adherence, i.e.…”

Section: Discussionmentioning

confidence: 99%

Non-adherence to medication and doctor–patient relationship: Evidence from a European survey

Stavropoulou

2011

Patient Education and Counseling

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Determinants of subject compliance within an experimental anti-HIV drug protocol

Cited by 106 publications

References 13 publications

Adherence to Anti-Retroviral Therapy among People Living with HIV and AIDS in Far West, Nepal

Adherence to Anti-Retroviral Therapy among People Living with HIV and AIDS in Far West, Nepal

Characteristics of HIV antiretroviral regimen and treatment adherence

Non-adherence to medication and doctor–patient relationship: Evidence from a European survey

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