Determinants of splanchnic blood flow

Takala, Jukka

doi:10.1093/bja/77.1.50

Cited by 211 publications

(133 citation statements)

References 67 publications

(131 reference statements)

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“…Uusardo et al [15] showed that hepatic blood flow can be used as an approximation for splanchnic perfusion. Hepatic blood flow can be affected by the autonomous nervous system, a number of endocrine responses and the volume status of the body [16]. Hypovolaemia, increased angiotensin II levels and stress can lead to a decrease in Table 3 Haemodynamic data recorded at baseline, pre-induction and most-induction measurements.…”

Section: Discussionmentioning

confidence: 99%

The effect of a pre‐operative infusion of Ringer's solution on splanchnic perfusion in patients undergoing coronary artery bypass grafting

Klein¹,

Osmer

Müller

et al. 2002

Anaesthesia

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SummarySurgical patients develop a fluid deficit during pre-operative starvation. This study examines the effects of pre-operative fluid administration on haemodynamic variables, oxygenation and splanchnic perfusion in patients undergoing elective coronary artery bypass grafting. Forty-eight patients were randomised to receive either a pre-operative crystalloid infusion (crystalloid group, n ¼ 24) or no infusion (control group, n ¼ 24). Patients in the crystalloid group received a continuous infusion of Ringer's solution at 1.5 ml.kg )1 .h )1 from 22:00 h until induction of anaesthesia the next morning. Immediately before induction of anaesthesia, all patients were given a colloid infusion to increase pulmonary capillary wedge pressure and central venous pressure to similar levels in both groups. Haemodynamic and oxygenation parameters were measured using invasive cardiovascular monitoring, and splanchnic perfusion was assessed by indocyanine green clearance. Patients in the crystalloid group received a mean (SD) of 1008 (140) ml of Ringer's solution overnight. Patients in the crystalloid group had a higher splanchnic blood flow than the control group before induction of anaesthesia [mean (SD) ¼ 1782 (573) ml.min )1 vs. 1391 (333) ml.min )1 , p < 0.05]. There were no significant differences in systemic haemodynamic data and global oxygenation parameters between the two groups. Pre-operative infusion of crystalloid appears to result in an improvement in pre-operative splanchnic perfusion.

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Section: Discussionmentioning

confidence: 99%

The effect of a pre‐operative infusion of Ringer's solution on splanchnic perfusion in patients undergoing coronary artery bypass grafting

Klein¹,

Osmer

Müller

et al. 2002

Anaesthesia

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“…One of the potential limitations of PMO treatment is the limited amount of blood flow through the splanchnic circuit. In humans, only 20-30% of the total blood volume passes through the peritoneal region [43], which is similar to rabbits where total splanchnic circulation is 22% of the total blood flow [44]. This limits the amount of oxygen that can be transported from the peritoneum, which may explain the difficulty in maintaining normoxic levels in this complete asphyxiation model.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of Peritoneal Microbubble Oxygenation Therapy in a Rabbit Model of Hypoxemia

Legband

Feshitan²,

Borden

et al. 2015

IEEE Trans. Biomed. Eng.

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Abstract-Alternative extrapulmonary oxygenation technologies are needed to treat patients suffering from severe hypoxemia refractory to mechanical ventilation. We previously demonstrated that peritoneal microbubble oxygenation (PMO), in which phospholipid-coated oxygen microbubbles (OMBs) are delivered into the peritoneal cavity, can successfully oxygenate rats suffering from a right pneumothorax. This study addressed the need to scale up the procedure to a larger animal with a splanchnic cardiac output similar to humans. Our results show that PMO therapy can double the survival time of rabbits experiencing complete tracheal occlusion from 6.6 ± 0.6 min for the saline controls to 12.2 ± 3.0 min for the bolus PMO-treated cohort. Additionally, we designed and tested a new peritoneal delivery system to circulate OMBs through the peritoneal cavity. Circulation achieved a similar survival benefit to bolus delivery under these conditions. Overall, these results support the feasibility of the PMO technology to provide extrapulmonary ventilation for rescue of severely hypoxic patients.Index Terms-Acute lung injury (ALI), acute respiratory distress syndrome (ARDS), airway obstruction, extrapulmonary ventilation, oxygen delivery.

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“…We showed the potential beneficial effect of NO-induced local vasodilation, particularly in the mesenteric circulation (22). Since splanchnic ischemia increases mortality in septic shock (23), the restoration of tissue perfusion by local vasodilation via NO may reduce the bacterial translocation (24) and improve survival (25).…”

Section: Introductionmentioning

confidence: 89%

The effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid(NCX 4016) on mice models of endotoxic and septic shock

Ulu¹,

İskit

Sökmensüer³

et al. 2015

Turk J Med Sci

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Background/aim: Nitric oxide-donating nonsteroidal antiinflammatory drugs (NO-NSAIDs) are a promising new class of antiinflammatory agents, which are obtained by adding NO-donating moieties to the existing conventional NSAID molecules. The aim of this study was to investigate the effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid (NCX 4016) on cecal ligation and puncture (CLP) and endotoxin-induced septic shock (LPS) models in mice. Materials and methods:Overall survival and spleen and liver weights were monitored in LPS and CLP models. Histopathological examinations of liver and spleen were performed at the end of the experimental protocols.Results: NCX 4016 was able to reverse the increased spleen weight in CLP-operated animals, whereas aspirin or flurbiprofen did not. Similar to the results of the CLP model, none of the drugs modified the survival rates in the LPS model. Flurbiprofen in particular produced significant histopathological damage in spleens and livers, which was less significant with aspirin. NCX 4016 did not cause any liver damage. Conclusion:NCX 4016 has the potential to be used in septic states, while special attention has to be paid to the effects of aspirin and flurbiprofen on the liver and spleen.

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Determinants of splanchnic blood flow

Cited by 211 publications

References 67 publications

The effect of a pre‐operative infusion of Ringer's solution on splanchnic perfusion in patients undergoing coronary artery bypass grafting

The effect of a pre‐operative infusion of Ringer's solution on splanchnic perfusion in patients undergoing coronary artery bypass grafting

Evaluation of Peritoneal Microbubble Oxygenation Therapy in a Rabbit Model of Hypoxemia

The effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid(NCX 4016) on mice models of endotoxic and septic shock

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