Determinants of sleep problems in patients with spondyloarthropathy

Abstract

Sleep problems are prevalent among patients with SpA. Our findings suggest that multiple factors are associated with sleep complaints in persons with SpA with functional status, depressed mood and stress differentially contributing to specific sleep parameters. Multimodal interventions, which include non-pharmacological methods targeting these biopsychosocial factors, require evaluation to optimize the management of sleep disruptions in SpA.

Prevalence and factors associated with disturbed sleep in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review

“…Psychological factors such as mood have been shown to contribute to sleep disturbance in rheumatoid arthritis [ 13 ] and in a mixed SpA population [ 15 ]. This review also showed that psychological factors such as depression, anxiety and overall QoL are associated with poor sleep quality for patients with AxSpA [ 21,25,32 ].…”

“…Awakening in the early morning hours may help distinguish inflammatory back pain from mechanical low back pain [ 5 ]. Prevalence of disturbed sleep is evident in other chronic inflammatory conditions such as psoriatic arthritis [ 9,10 ], rheumatoid arthritis [ 11 ] and inflammatory bowel disease [ 12 ], and research suggests that disturbed sleep is associated with active disease, pain, reduced physical functioning, demographics and mood within these wider populations [ 13,14,15 ].…”

Severity of the Apnea-Hypopnea Sleep Syndrome in Patients with Rheumatoid Arthritis and Spondyloarthropathies. Modulation of the Sleep Apnea Index with Anti-TNF-? Inhibitors

“…IL-6 contributes to the formation and instability of the atheromatous plaque and may trigger an acute coronary episode [24]. SAHS is also generally associated to higher CV risk, especially in young subjects [8]. Patients with SAHS usually also have increased TNF-α and IL-6, [25] that is also related to AHI, independently of obesity.…”

“…Sleep abnormalities are common in RA [7,8] and SAHS has been attributed as being a factor that contributes to CV mortality in patients with RA [9]. There seems to be a systemic inflammatory component in the etiopathogeny of SAHS, although the mechanism is little known.…”

“…Sleep apnea-hypopnea syndrome (SAHS) has a 3-4% [4] prevalence in Western countries and is also associated to the metabolic syndrome and other CV risk factors [5]. SAHS per se constitutes an independent CV risk factor in male subjects and young subjects with this disease [6].Sleep abnormalities are common in RA [7,8] and SAHS has been attributed as being a factor that contributes to CV mortality in patients with RA [9]. There seems to be a systemic inflammatory component in the etiopathogeny of SAHS, although the mechanism is little known.…”