Determinants of seizure occurrence in preeclampsia before commencing and during treatment with magnesium sulphate

Imaralu, John Osaigbovoh; Badejoko, Olusegun O.; Loto, Olabisi M.; Ihongbe, John C.

doi:10.18203/2320-1770.ijrcog20163404

Cited by 1 publication

(1 citation statement)

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“…19 Low serum magnesium levels have been consistently associated with occurrence of seizures in preeclamptics. 20,[22][23][24] As technological advances now allow for ionized magnesium to be more easily measured, questions have arisen as to whether it is more appropriate to monitor total serum magnesium, which is cheaper to do, or the ionized, physiologically active, form. In a study on preeclamptic patients that received 4g intravenous loading dose followed by hourly 2g infusions of magnesium sulphate, it was observed that both total and ionized Mg +2 concentrations increased rapidly after infusion, but steady-state concentrations for total magnesium were 4.84±0.24 mg/ dL, whereas for ionized magnesium it was 2.04±0.14 mg/Dl.…”

Section: Magnesium Levels In Normal and Preeclamptic Pregnanciesmentioning

confidence: 99%

Evolution of magnesium sulphate for eclampsia

Imaralu¹,

Imaralu²

2018

OGIJ

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Eclampsia with its precursor preeclampsia is a condition that is rapidly taking the fore front in many countries as the leading cause of adverse maternal outcome, because of gains accruing from ability to curb, the better-understood obstetric haemorrhage. The exact mechanism by which preeclampsia leads to eclampsia remains unclear resulting in difficulty in prediction of individuals with preeclampsia who would develop eclampsia. Magnesium sulphate has been a recognised remedy since the early twentieth century, becoming scientifically proven and increasingly popular in the last two decades. However, the exact mechanism of action of magnesium sulphate in alleviating and preventing seizures still remains elusive and fits have been observed to occur during magnesium sulphate therapy. Better understanding of magnesium homeostasis in pregnancy and improved knowledge of the effects of magnesium sulphate may help unravel the mystery behind the cause and course of eclampsia.

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