Determinants of resting regional cerebral blood flow in normal subjects

Effect of Cerebrovascular Risk Factors on Regional Cerebral Blood Flow

“…Furthermore, hypertension has been reported to be associated with a global decrease in cerebral blood flow (23). The discrepancies between these results and our study findings can probably be explained by differences in the study populations: In the previous studies (23,37,38), few patients with symptomatic atherosclerotic disease were included. In addition, all of these studies involved the use of xenon 133 inhalation SPECT, which has lower spatial resolution and reliability compared with 99m Tc-hexamethylpropyleneamine oxime SPECT and ASL MR imaging (39).…”

“…A significant positive association between systolic blood pressure and rCBF was also found in that previous study (36). In other studies, however, either no significant association (37) or an inverse association (38) between blood pressure and rCBF has been reported. Furthermore, hypertension has been reported to be associated with a global decrease in cerebral blood flow (23).…”

Brain Morphological Changes and Early Marijuana Use

“…It is generally accepted that females have a higher resting CBF than males, [54][55][56] and in the present study this expected main effect of sex was confirmed. However, CBF of males who started using marijuana early was not different from females, and was significantly higher than males who started smoking after age 17.…”

Changes in Cerebral Blood Flow and Mental State after Amphetamine Challenge in Schizophrenic Patients

“…This finding was subsequently replicated by several investigators [5,[10][11][12][13][14][15][16] but not by several others [4,[17][18][19][20][21][22], A number of factors may have contributed to this inconsistency [5]. CBF is influenced by several non specific factors, which tend to blur comparisons between patients and controls [23][24][25]. Most CBF studies on schizophrenia compared patients with controls.…”