2002
DOI: 10.1152/ajprenal.0157.2001
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Determinants of renal microvascular response to ACh: afferent and efferent arteriolar actions of EDHF

Abstract: The renal microvascular actions of ACh were investigated using the in vitro perfused hydronephrotic rat kidney. ACh reversed ANG II-induced vasoconstriction in the afferent and efferent arteriole by 106 ± 2 and 75 ± 5%, respectively. Inhibition of nitric oxide synthase [NOS; 100 μmol/l N G-nitro-l-arginine methyl ester (l-NAME)] and cyclooxygenase (COX; 10 μmol/l ibuprofen) prevented the sustained response of the afferent arteriole but did not reduce the magnitude of the initial dilation (97 ± 7%). However, NO… Show more

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Cited by 51 publications
(66 citation statements)
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References 42 publications
(50 reference statements)
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“…As shown, neither of these treatments was capable of eliminating the response to SLIGRL-NH 2 , although each treatment attenuated the response. In concert with our previous observations (43,44), these findings suggest that the NO-independent response to SLIGRL-NH 2 involves a separate or an additional mechanism that is not seen with either acetylcholine or bradykinin.…”
Section: Methodssupporting
confidence: 87%
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“…As shown, neither of these treatments was capable of eliminating the response to SLIGRL-NH 2 , although each treatment attenuated the response. In concert with our previous observations (43,44), these findings suggest that the NO-independent response to SLIGRL-NH 2 involves a separate or an additional mechanism that is not seen with either acetylcholine or bradykinin.…”
Section: Methodssupporting
confidence: 87%
“…We have previously characterized the nature of the EDHFlike responses of the afferent arteriole to acetylcholine (43) and bradykinin (44), and these findings along with the present results are summarized in Fig. 10.…”
Section: Discussionsupporting
confidence: 59%
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