Determinants of quality of life in chronic liver patients

Gutteling, J. J.; Man, Robert A. de; Plas, Simone M. van der; Schalm, Solko W.; Busschbach, Jan J. V.; Darlington, Anne‐Sophie

doi:10.1111/j.1365-2036.2006.02934.x

Cited by 106 publications

(125 citation statements)

References 32 publications

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“…The majority of studies have analyzed viral etiology of CLD followed by alcoholic liver disease, NASH, holestatic liver disease, autoimmune hepatitis, and medicamentous hepatitis [13][14][15]. There are concordant results in other similar studies regarding the average age of participants, gender, marital status, and educational status [8,[15][16][17].…”

Section: Discussionsupporting

confidence: 58%

“…Moreover, an increasing number of patients with "mild" distress was a characteristic for the group of patients with cirrhosis, but without statistical significance in terms of frequency distribution. Our results differ from literature data [14]. According to the most relevant studies, generic QoL score (mainly assessed by SF-36 questionnaire) was significantly lower within the patients with CLD compared with healthy controls, including the studies of Bondini et al [20], which indicate significantly lower SF-36 scores in patients with cholestatic liver diseases and viral hepatitis C in comparison with the control group.…”

Section: Discussioncontrasting

confidence: 57%

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A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study

Obradović

Gluvić

Petrović

et al. 2017

Romanian Journal of Internal Medicine

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Introduction. Chronic liver diseases (CLD) are an important cause of morbidity and mortality in general population. The aim of this study was to analyze potential differences between patients with CLD and healthy control group, and to estimate the severity of CLD by using simple questionnaires: general health questionnaire (GHQ-12) and chronic liver disease questionnaire (CLDQ).Methods. A cross-sectional pilot study was performed in Zemun Clinical Hospital during years 2014 and 2015. Sixty participants were divided into 4 groups (15 per group): chronic alcoholic hepatitis, other chronic hepatitis, liver cirrhosis, and healthy control group. Entire study population chose one of four offered answers of structured questionnaires GHQ-12 and CLDQ, based on which mean model of end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores were calculated.Results. Mean GHQ12 and CLDQ scores were 10.5 and 5.21 ± 1.11 respectively. Regarding certain CLDQ domain scores, a significant difference between alcoholic and non-alcoholic hepatitis groups in the worry domain was observed. Mean MELD score was 7.42 ± 2.89 and did not differ between chronic hepatitis groups, while mean CTP score was 5.73 ± 0.88. A statistically significant correlation was observed between GHQ12 and CLDQ scores (ρ = -0.404, p < 0.01), but not between subjective and objective scores.Conclusions. Mean GHQ12 and CLDQ scores pointed out to general psychological no-distress condition of the studied participants, as well as scarcely expressed CLD-specific complaints. Mean MELD and CTP scores indicated stable chronic liver diseases, with low three-month mortality rates in the cases of chronic hepatitis, as well as determination to Child A group in the case of liver cirrhosis.

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Section: Discussionsupporting

confidence: 58%

Section: Discussioncontrasting

confidence: 57%

A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study

Obradović

Gluvić

Petrović

et al. 2017

Romanian Journal of Internal Medicine

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“…The SF-36 has been compared to the CLDQ in a number of studies. Reasonably good correlations between the SF-36/SF-6D and CLDQ for most domains were found and similar changes in both tools with disease progression have been reported (28)(29)(30). We, therefore, feel the SF-36 is a suitable tool for calculating costeffectiveness of the two procedures.…”

Section: Discussionmentioning

confidence: 85%

Cost of preventing variceal rebleeding with transjugular intrahepatic portal systemic shunt and distal splenorenal shunt

Boyer

Henderson

Heerey

et al. 2008

Journal of Hepatology

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Background and aims-We examined the cost and cost effectiveness of distal splenorenal shunt (DSRS) and transjugular intrahepatic portosystemic shunt (TIPS) in the prevention of variceal rebleeding. Subjects-Participants in randomized controlled trial comparing DSRS to TIPS.Methods-Quality of life (QOL) measured using SF-36 preceding randomization and yearly thereafter. Cost utility analysis was performed using Data Treeage ®. Costs for both in-and outpatient events and interventions were obtained for each patient. Costs using coated stents were estimated using different rates of stenosis. Incremental cost effectiveness ratios (ICERs) were determined at 1, 3 and 5 years.Results-The average yearly costs of managing patients after TIPS and DSRS over 5 years were similar, $16,363 and $13,492 respectively. Cost of TIPS for surviving patients exceeded the cost of DSRS at years 3 and 5 but not significantly. ICERs per life saved favored TIPS at year 5 ($61,000). If coated rather than bare stents were used the cost-effectiveness of TIPS increased slightly.Conclusions-TIPS is as effective as DSRS in preventing variceal rebleeding and may be more cost effective. TIPS, in all aspects, is equal to DSRS in the prevention of variceal rebleeding in patients who are medical failures.

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“…34,37 Gutteling et al 37 applied linear regression analyses to the results of the Liver Disease Symptom Index 2.0 and the Short Form 6D to assess the impact of quality-of-life determinants on patients with chronic liver disease and found that fatigue was strongly related to HRQL (B ϭ Ϫ0.030). However, the relationship between fatigue and liver disease is not yet determined.…”

mentioning

confidence: 99%