Determinants of quality of life after lung transplant: an Italian collaborative study

Ricotti, S.; Vitulo, Patrizio; Petrucci, Lucia; Oggionni, Tiberio; Klersy, Catherine

doi:10.4081/monaldi.2006.579

Cited by 10 publications

(5 citation statements)

References 18 publications

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“…CF patients were found to report the best self-perceived quality of well-being. Furthermore, Ricotti and collegues confirmed these findings [5].…”

Section: Discussionmentioning

confidence: 55%

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Determinants of Quality of Life After Lung Transplantation

Ihle¹,

Zimmermann²,

Meis³

et al. 2015

TOTRANSJ

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Background: The purpose of this study was to examine clinical and non-clinical determinants of quality of life (QoL) in lung transplant recipients (LTR). Methods: QoL was measured cross-sectional in 152 LTR (4.5±3.2 years after lung transplantation [LTx]; 95 [63%] double LTx; 80 [53%] female; age 50±11.9 years; 28 [18%] bronchiolitis obliterans syndrome (BOS) stage ≥ 1) using the SF-36, the "Quality of Life Profile for Chronic Diseases Questionnaire" as well as the "St. Georges` Respiratory Questionnaire". Gender, age, body mass index (BMI), time after LTx, procedure type, underlying disease, marital-and professional status and exercise capacity (6-minute walk test, 6MWT) were tested for their predictive value by non-parametric significance tests and ANOVA and ANCOVA. Results: There was a significant correlation with higher physical QoL scores for age < 48 years (p<0.05), a BMI of 21.0-25.2 kg/m 2 (p<0.05), a 6MWT≥ 430m (p<0.001), for cystic fibrosis patients (p<0.05) without BOS (p<0.05) and who go to work (p=0.018). Females boasted a superior social health (p=0.04) and less respiratory symptoms (p=0.023). Double LTx was a significant predictor for both, mental and physical health (p<0.05). Subsequent analysis of covariance revealed only BMI (p=0.024), BOS stage (p<0.001), underlying disease (p=0.01) and exercise capacity according to 6MWT (p<0.001) as significant predictors for QoL independent of age. Conclusion: The study results suggest that returning to normal BMI and improving exercise capacity seem to be important therapeutic approaches to enhance QoL after LTx. Future investigations should focus on prophylaxis and therapy of BOS to further optimize QoL after LTx.

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“…CF patients were found to report the best self-perceived quality of well-being. Furthermore, Ricotti and collegues confirmed these findings [5].…”

Section: Discussionmentioning

confidence: 55%

“…Various clinical studies investigated psychological problems, physical condition, diagnosis and individual characteristics for their potential to influence HRQOL and elucidated debatable values for these variables [4][5][6][7]. However, clinical and non-clinical predictors of HRQOL are still controversial.…”

Section: Introductionmentioning

confidence: 99%

Determinants of Quality of Life After Lung Transplantation

Ihle¹,

Zimmermann²,

Meis³

et al. 2015

TOTRANSJ

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“…Although the largest prospective study to date, described earlier, shows that older age did not impact improvements in HRQL at a level that exceeded the MCID, most of the literature demonstrates lower HRQL in older lung transplant recipients. 13,16,[109][110][111] Although the reasons for these discrepancies are not clear, it is possible that the system of lung allocation may be relevant. The study that found no association between age and HRQL was performed in Canada, where allocation is based on a more subjective assessment of the need for transplant instead of the LAS or time accrued on the waiting list.…”

Section: How Patient-specific Factors Impact Improvements In Hrql Aftmentioning

confidence: 99%

Defining Success in Lung Transplantation: From Survival to Quality of Life

Kolaitis

Singer

2018

Semin Respir Crit Care Med

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Lung transplantation (LT) has the potential to extend survival and improve quality of life (QOL) for patients suffering from end-stage lung disease. This review describes the many ways in which success can be defined in LT. It evaluates the improvements in survival outcomes after LT over time, and describes ways to measure the success of LT other than survival after transplantation. It also addresses the importance of patient-centered outcomes and how improvements in health-related quality of life (HRQL) are pivotal to defining success within LT.

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“…General HRQoL was measured using the internationally validated SF-36 [16][17][18][19][20]. In particular, we used the Italian version of the SF-36 (version 1.6), created by the International Quality of Life Assessment Project.…”

Section: Health-related Quality Of Life Instrumentsmentioning

confidence: 99%

Changes in quality of life and functional capacity after lung transplantation: A single-center experience

Ricotti

Martinelli

Caspani

et al. 2017

Monaldi Arch Chest Dis

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Lung transplantation (LT) increases the life expectancy of patients affected by end stage pulmonary disease; specifically, its ultimate aims are to improve survival and health related quality of life (HRQoL). The aim of the present longitudinal study was to determine the HRQoL trajectory and changes in functional capacity from time of entry in the waiting list for LT to 2 year after LT. The study included sixty-nine outpatients enrolled in a single medical center when they entered the waiting list for LT and who subsequently received it. They were then followed up over 2 years after LT. HRQoL was assessed by the physical and mental component summary (PCS and MCS) scores of the 36-item Short Form Health Survey (SF-36) and Saint George's Respiratory Questionnaire (SGRQ). Psychological distress was evaluated with the General Health Questionnaire (GHQ), and functional capacity was investigated using the six-minute walk test (6MWT) and forced expiratory volume (FEV1). Patients showed low SF-36 PCS (30.5±7.8) and SGRQ total (61.8±17.5) scores at entry in the waiting list, but exhibited significant changes over time after LT (p<0.001). Furthermore, patients who showed an increase of at least 50% in SF36 PCS and SGRQ scores at 6 months survived longer. Both FEV1 and 6MWT distance as well as GHQ scores significantly changed over time, with improvements occurring in the first 6 months after LT but no major changes thereafter. Out of the 69 patients enrolled, 32 died over a median follow-up of 51 months. Although mortality tended to be slightly higher for patients with lower HRQoL at the baseline assessment, this difference was not statistically significant. HRQoL evaluations appear critical in the follow-up of LT candidates, in particularly SGRQ, because of its specificity in targeting respiratory symptoms and functional wellbeing.

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Determinants of quality of life after lung transplant: an Italian collaborative study

Cited by 10 publications

References 18 publications

Determinants of Quality of Life After Lung Transplantation

Determinants of Quality of Life After Lung Transplantation

Defining Success in Lung Transplantation: From Survival to Quality of Life

Changes in quality of life and functional capacity after lung transplantation: A single-center experience

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