Determinants of quality of life in people with epilepsy and their gender differences

Li, Yue; Yu, Peimin; Zhao, De-hao; Wu, Dalei; Zhu, Guangfa; Wu, Xunyi; Hong, Zhen

doi:10.1016/j.yebeh.2011.08.022

Cited by 63 publications

(46 citation statements)

References 40 publications

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“…With low level of education, and given the culture perception of the epilepsy in the Northern Province where participants were recruited, respondents in this study are hypothesized to have limited knowledge on epilepsy etiology and treatment that orient their subjection perception of the burden. This is consistent with research findings indicating positive correlation between education level and quality of life in female epileptics (Yue, et al, 2011). With regard culture influences and spiritual traditions, people in that specific region of Rwanda believe in supernatural forces, bewitchment or poisoning as causes of epilepsy (Fadiman, 1997).…”

Section: Discussionsupporting

confidence: 90%

“…Scholars assessing the relationship between the types of seizure and depression prevalence have argued that in patients with temporal lobe epilepsy, anticonvulsive drugs and psychosocial factors increase the likelihood of depression occurrence (Yue, et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…With regard to epilepsy treatment, it should be noted that untreated depression runs the risk of negatively impacting epileptic treatment compliance. Thus, neurologists should screen for depression and should include depression diagnosis and treatment in their routine clinical treatment of epilepsy (Yue, et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The scale can be used as a continuous outcome for analyses or a cut point can be applied for the likely depression diagnosis), distinguishes levels of depression prevalence such as absent (0-9 total score), minor (10-19 total score), moderate (20)(21)(22)(23)(24)(25)(26) and severe (27 and above). The HRSD Kinyarwanda version (translated by the Neuro-Psychiatric Hospital CARAES-NDERA) presented reliable internal consistency (=.96).…”

Section: Depression Screeningmentioning

confidence: 99%

See 3 more Smart Citations

Incidence of depression in Epilepsy patients

Sezibera¹,

Nyirasafari²

2013

RWJour

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show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Depression Screeningmentioning

confidence: 99%

See 2 more Smart Citations

Incidence of depression in Epilepsy patients

Sezibera¹,

Nyirasafari²

2013

RWJour

View full text Add to dashboard Cite

show abstract

“…1 Rather than focusing on symptomatic, seizure-suppressing treatment of established epilepsy, the prevention of the development of epilepsy (i.e., antiepileptogenesis) in patients at risk has been acknowledged as a major epilepsy research priority. 2,3 Approximately 10-20% of acquired epilepsy is caused by traumatic brain injury (TBI), 4 with the 30-year cumulative incidence of epilepsy being 2.1% for mild, 4.2% for moderate, and 16.7% for severe injuries.…”

Section: Introductionmentioning

confidence: 99%

MRI Biomarkers for Post-Traumatic Epileptogenesis

Immonen

Kharatishvili

Gröhn

et al. 2013

Journal of Neurotrauma

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The present study tested a hypothesis that early identification of injury severity with quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting increased seizure susceptibility and epileptogenesis after traumatic brain injury (TBI). TBI was induced by lateral fluid percussion injury (FPI) in adult rats. Quantitative T2, T1q, and diffusion were assessed with MRI at 9 days, 23 days, or 2 months post-TBI in the perilesional cortex, thalamus, and hippocampus. Seizure susceptibility was assessed at 12 months after TBI using the pentylenetetrazol seizure-susceptibility test. At 9 and 23 days post-TBI, a change in T1q of the perilesional cortex showed the greatest predictive value for increased seizure susceptibility at 12 months post-TBI [area under the curve (AUC), 0.929 and 0.952, respectively; p < 0.01]. At 2 months post-TBI, Dav in the thalamus was the best of the biomarkers analyzed (AUC, 0.988; p < 0.05). The highest predictive value of all biomarkers was achieved by combining the measurement of Dav in the perilesional cortex and the thalamus at 2 months post-TBI (AUC, 1.000; p < 0.01). Our results provide proof-of-concept evidence that clinically relevant MRI biomarkers predict increased seizure susceptibility after experimental TBI.

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Treatment of epilepsy in daily clinical practice: have outcomes improved over the past 10 years?

et al. 2013

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In the past decade, many new antiepileptic drugs have become available, but their influence on patient outcomes in daily practice is not well known. In a community-based study, we assessed changes in epilepsy treatment and outcomes over a 10-year period. We compared two cross-sectional community-based samples that were obtained from the same Dutch suburban region in 2000 and 2010 using pharmacy records for recruitment, including 344 and 248 epilepsy patients, respectively. The main outcome was self-reported quality of life (QoL, using the QOLIE-31). Potential predictors of QoL (adverse effects, seizure control, seizure acceptability, demographic, epilepsy- or treatment-related determinants) were assessed by multivariable linear regression. New antiepileptic drugs were used by 9 % of patients in 2000 and 34 % in 2010, P < 0.001. More than 80 % in both samples reported to be treated by a neurologist. We found no significant differences in QOLIE-31 scores (72.57 vs. 72.44), or in the proportion of patients with complete seizure control (51 vs. 54 %), between the two study samples. Seizure control and adverse effects were important independent predictors of quality of life, explaining 58 % of the variance. We found no evidence that in this community the QoL of epilepsy patients has improved in the last decade, despite unrestricted availability of healthcare resources, including accessibility to new AEDs. The relatively low proportion with complete seizure control and the high rate of adverse effects in these community-based samples suggest that the effectiveness of epilepsy treatment is still far from optimal.

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Determinants of quality of life in people with epilepsy and their gender differences

Cited by 63 publications

References 40 publications

Incidence of depression in Epilepsy patients

Incidence of depression in Epilepsy patients

MRI Biomarkers for Post-Traumatic Epileptogenesis

Treatment of epilepsy in daily clinical practice: have outcomes improved over the past 10 years?

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