Determinants of quality of life in advanced cancer patients with bone metastases undergoing palliative radiation treatment

Lam, Kinsey; Chow, Edward; Zhang, Liying; Wong, Erin; Bedard, Gillian; Fairchild, Alysa; Vassiliou, Vassilios; El-Din, Mohamed A. Alm; Filho, Reynaldo Jesus Garcia; Kumar, Aswin; Forges, Fabien; Tseng, Ling‐Ming; Hou, Ming‐Feng; Chie, Wei‐Chu; Bottomley, Andrew

doi:10.1007/s00520-013-1876-6

Cited by 37 publications

(34 citation statements)

References 27 publications

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“…To determine whether patients with an intermediate level of PD at baseline might have more chance of converting to a high level of PD during follow-up, the patients below the cutoff value were divided into two groups: low (7)(8)(9)(10)(11) and an intermediate (12)(13)(14)(15)(16) level.…”

Section: Psychological Distressmentioning

confidence: 99%

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Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

et al. 2017

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Background: Psychological distress (PD) has a major impact on quality of life. We studied the incidence of PD before and after radiotherapy for painful bone metastases. Furthermore, we aimed to identify factors predictive for PD. Methods: Between 1996 and 1998, the Dutch Bone Metastasis Study included 1157 patients with painful bone metastases. Patients were randomized between two fractionation schedules. The study showed a pain response of 74% in both groups. Patients filled out weekly questionnaires for 13 weeks, then monthly for two years. The questionnaires included a subscale for PD on the Rotterdam Symptom Checklist. We used generalized estimating equations and multivariable logistic regression analyses. Results: At baseline, 290 patients (27%) had a high level of PD. For the entire group, the level of PD remained constant over time. The majority of patients with a low level of PD at baseline remained at a low level during follow-up. In patients with a high level of PD at baseline, the mean level of PD decreased after treatment and stabilized around the cutoff level. Female patients, higher age, worse performance, lower pain score and worse self-reported QoL were associated with an increased chance of PD, although the model showed moderate discriminative power. Conclusions: A substantial proportion of patients had a high level of PD before and after radiotherapy for painful bone metastases. Most patients who reported high levels of PD when referred for palliative radiotherapy remained at high levels thereafter. Therefore, screening of PD prior to treatment seems appropriate, in order to select patients requiring intervention.

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Section: Psychological Distressmentioning

confidence: 99%

“…Painful bone metastases have a negative impact on the QoL of patients [5,6]. Studies show that radiotherapy stabilizes or improves QoL [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

et al. 2017

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“…Unlike populations without cancer, insomnia is inversely related with age in patients with cancer at mixed sites [21,23,28,44] and also among men with prostate cancer [42,49] . Younger men are also more likely to develop insomnia syndrome [42] , suggesting that younger men may have more trouble adjusting to their 'new normality' and consequently, are more susceptible to chronic sleeping difficulties.…”

Section: Predisposing Factors Agementioning

confidence: 99%

“…One such study described that the onset of symptoms was secondary to prostate cancer diagnosis in doi: 10.18282/amor.v2.i2.94 54% of men experiencing insomnia syndrome [42] . The majority of longitudinal studies described the highest prevalence of insomnia, or highest insomnia scores indicating worse symptomology, at the time point closest to diagnosis [23][24][25]49] . In one longitudinal study, 15% of the men reported that their first episode of insomnia coincided with their diagnosis [24,25] .…”

Section: Precipitating Factors Cancer Diagnosismentioning

confidence: 99%

“…In studies investigating the HRQoL of men with prostate cancer, insomnia is consistently the symptom that receives the highest score [19] or one of the highest scores, indicating worse symptomology [8,12,14,15,23,26] . Higher symptomology is associated with lower HRQoL among men with prostate cancer into survivorship [14] .…”

Section: Impact Of Insomnia On Men With Prostate Cancer Hrqolmentioning

confidence: 99%

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Are we sleeping on the job? Insomnia among men with prostate cancer

Drummond

2016

Adv Mod Oncol Res

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Prostate cancer is one of the most commonly diagnosed cancers in men and almost half of male cancer survivors in the US have had a prostate cancer diagnosis. Insomnia is common among cancer patients and survivors. There is evidence that cognitive behavioural therapy can be used to effectively manage insomnia among women with breast cancer. The aim of this review was to investigate the prevalence, risk factors and management of insomnia among men with prostate cancer. The effect of insomnia on the psychological health and health-related quality of life of these patients and/or survivors is also discussed. Increased awareness and knowledge of this symptom among men with prostate cancer may facilitate improved diagnosis, and management of insomnia in this large population. This in turn may improve the health-related quality of life of these men. Therefore, research into the effective management of insomnia among men with prostate cancer is essential.Keywords: prostate cancer; insomnia; androgen deprivation therapy; radiotherapy; health-related quality of life; depression; anxiety

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Determinants of quality of life in patients with incurable cancer

Daly

Dolan

Power

et al. 2020

Cancer

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BACKGROUND: Optimizing quality of life (QoL) remains the central tenet of care in patients with incurable cancer; however, determinants of QoL are not clear. The objective of the current study was to examine which factors influence QoL in patients with incurable cancer. METHODS: A multicenter study of adult patients with advanced cancer was conducted in Ireland and the United Kingdom between 2011 and 2016. Data were collected from patients at study entry and included patient demographics, Eastern Cooperative Oncology Group performance status (ECOG-PS), nutritional parameters (the percentage weight loss [%WL]), muscle parameters assessed using computed tomography images (skeletal muscle index and skeletal muscle attenuation), inflammatory markers (modified Glasgow Prognostic score [mGPS]), and QoL data (the European Organization for Research and Treatment Quality-of-Life Questionnaire C-30). The relation between clinical, nutritional, and inflammatory parameters with QoL was assessed using the Spearman rank correlation coefficient and multivariate binary logistic regression. Components of the European Organization for Research and Treatment Quality-of-Life Questionnaire C-30 (physical function, fatigue, and appetite loss) and summary QoL scores were mean-dichotomized for the logistic regression analyses. RESULTS: Data were available for 1027 patients (51% men; median age, 66 years). Gastrointestinal cancer was most prevalent (40%), followed by lung cancer (26%) and breast cancer (9%). Distant metastatic disease was present in 87% of patients. The %WL, ECOG-PS, and mGPS were significantly correlated with deteriorating QoL functional and symptom scales (all P < .001). On multivariate regression analysis, >10% WL (odds ratio [OR], 2.69; 95% CI, 1.63-4.42), an ECOG-PS of 3 or 4 (OR, 14.33; 95% CI, 6.76-30.37), and an mGPS of 2 (OR, 1.58; 95% CI, 1.09-2.29) were independently associated with poorer summary QoL scores. These parameters were also independently associated with poorer physical function, fatigue, and appetite loss (all P < .05). Low skeletal muscle attenuation was independently associated with poorer physical functioning (OR, 1.67; 95% CI, 1.09-2.56), but muscle parameters were not independently associated with fatigue, appetite loss, or QoL summary scores. CONCLUSIONS: The current findings indicate that QoL is determined (at least in part) by WL, ECOG-PS, and the systemic inflammatory response in patients with advanced cancer. Identifying early predictors of poor QoL may allow the identification of patients who may benefit from early referral to palliative and supportive care, which has been shown to improve QoL. Cancer 2020;126:2872-2882.

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Determinants of quality of life in advanced cancer patients with bone metastases undergoing palliative radiation treatment

Cited by 37 publications

References 27 publications

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

Are we sleeping on the job? Insomnia among men with prostate cancer

Determinants of quality of life in patients with incurable cancer

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