Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis

Yalachkov, Yavor; Soydaş, Dilara; Bergmann, Johannes; Frisch, Stefan; Behrens, Marion; Foerch, Christian; Gehrig, Johannes

doi:10.1016/j.msard.2019.01.049

Cited by 72 publications

(56 citation statements)

References 29 publications

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“…Our assessment further underlines this opinion, as we have shown that the less evaluated, yet frequently prevalent psychological burdens of the disease (particularly depression and fatigue) are the main determinants of the self‐reported well‐being of PwMS. We have confirmed other studies' findings (Yalachkov et al, ), that fatigue and depression are the main determinants of MS patients' HRQoL not only at disease onset, as previously shown (Nourbakhsh, Julian, & Waubant, ; when one would expect a patient to have a drop in their HRQoL, and become burdened with depression, after being diagnosed with a lifelong, degenerative disease), but years after the diagnosis as well. Therefore the evaluation and treatment of PwMS should be conducted on a much broader spectrum than regular physical and MRI examinations, even in the youngest population (Rainone et al, ), a pre‐emptive approach is proposed.…”

Section: Resultssupporting

confidence: 92%

Contributing factors to health‐related quality of life in multiple sclerosis

et al. 2019

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Background Health‐related quality of life (HRQoL) is lower in people with multiple sclerosis (PwMS) compared to the healthy population, psychological symptoms accompanying multiple sclerosis (MS) have a serious impact on the HRQoL of PwMS. Data regarding the subject, however, remain conflicting. Objectives To evaluate the patients' sociodemographic attributes, education, fatigue, depression, and cognitive impairment level of impact on the HRQoL for the whole cohort as well as comparing the sexes. Materials and Methods Three hundred and twenty‐two relapse‐remitting MS patients filled out the Fatigue Impact Scale (FIS), Beck Depression Inventory (BDI), MS Quality of Life‐54 (MSQoL‐54) questionnaires, cognitive impairment were identified using Brief International Cognitive Assessment for MS (BICAMS) test. The patients' data were acquired from our clinic's MS registry or from patients' files. Results Depression and fatigue were found to have the most ubiquitous and robust effect on the overall and any given subdivision of the HRQoL composite. Other factors had a slight effect on some of the subscales when the whole cohort was evaluated. When the genders were compared, differences were found on 10 domains. Conclusion Psychopathological symptoms have a more powerful influence on the HRQoL of MS patients than physical impairment, also these symptoms influence men's and women's HRQoL with different power. This invokes the need for complex and personalized care in the treatment of PwMS. Ours is the first study to show a difference between the sexes in this regard.

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Section: Resultssupporting

confidence: 92%

Contributing factors to health‐related quality of life in multiple sclerosis

et al. 2019

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“…These are emotions related to depression. Depression and psychological distress are factors that have a significant impact on the MS patients' QoL [22].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies focused on the impact of certain intervention on the MS patients' QoL, for example, aerobic training on fitness [5,13,14], exercise and physiotherapy [15], disease-modifying drugs [16], and diet [17], or they attempt to evaluate the agreement levels between neurologists and patient's perception of QoL [18]. Furthermore, some studies analyzed the connections among the MS patients' QoL, tiredness, depression, disability [19][20][21][22], selfperceived limitations [23], cognitive impairment [10], or social support [24]. Factors that impact the QoL were the focus of the work of Lobentanz et al [9], Berrigan et al [25], and Yamout et al [26].…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Health-Related Quality of Life of Patients with Multiple Sclerosis and Their Caregivers

Bužgová

Kozáková

Škutová³

2020

Eur Neurol

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Background: Only a few studies have been done focusing on the quality of life (QoL) of patients with multiple sclerosis (MS) as well as their family members. The aim of our research was to determine the factors that influence the QoL of MS patients in advanced stage of disease and their caregivers. Methods: The sample of the cross-sectional study included 153 patients with MS and 74 caregivers. QoL was measured using the PNDQoL questionnaire (Progressive Neurological Diseases Quality of Life), and the severity of illness was assessed through the following scales: EDSS (Expanded Disability Status scale), PPS (Palliative Performance Scale), and ADL (Activity Daily Living). Results: The following predictors of the global QoL of the MS patients were identified – age, EDSS, symptom burden, daily care, emotional functioning, and spiritual_nonreligion functioning (R2 = 0.569; F = 32.900; p < 0.001). The following predictors of the global QoL of caregivers were identified – age, emotional functioning, spiritual_nonreligion functioning, patient’s QoL, and feeling of care (R2 = 0.431; F = 18.690; p < 0.001). Conclusion: Appropriate intervention should be directed particularly at older patients and caregivers who have faced the disease for longer time and at patients without any partner. Supporting the emotional and social well-being and mitigating the burden caused by symptoms of the patients as well as caregivers can improve the QoL of both groups.

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“…La fatiga y la alteración en el estado de ánimo se han relacionado con alteración del funcionamiento cognitivo de las personas con EM (7,13,28,29) . La presencia de síntomas sensitivos y fatiga, generan un impacto negativo en actividades de la vida cotidiana, dado por la disminución en la sensación de vitalidad durante el día y empeoramiento de la función física, lo que se refleja en el deterioro de la CV e incremento de ausentismo laboral (8,12,(30)(31)(32) .…”

Section: Discussionunclassified

“…Se encontró que el 90% de los pacientes del estudio tuvieron riesgo leve o moderado de depresión evaluado con el test de Zung. De acuerdo con Olascoaga (13) , la presencia de factores psicológicos afecta de manera negativa la CV, por incremento en niveles de fatiga, disfunción física, incremento de dolor, alteraciones cognitivas y trastornos del sueño, que pueden reflejarse la falta de adherencia al tratamiento y deterioro CV de las personas con EM, que podría desencadenar un peor pronóstico (12,(32)(33)(34)(35)(36) .…”

Section: Discussionunclassified

Calidad de vida en pacientes con esclerosis múltiple atendidos en una institución de salud de Medellín, Colombia

Orozco-Gonzalez¹,

Vagner-Ramírez²,

Salas-Zapata³

2019

Univ. Salud

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Introducción: La calidad de vida relacionada con salud (CVRS) en la esclerosis múltiple (EM), puede verse afectada por factores físicos, clínicos y sociodemográficos. Objetivo: Determinar el efecto de factores sociodemográficos, clínicos y físicos en la calidad de vida (CV) de pacientes con EM. Métodos: Se aplicó el instrumento WHOQOL-BREF de la OMS a 173 pacientes de una institución de salud. Se realizó análisis descriptivo de características sociodemográficas, clínicas y físicas y sus puntajes de CV. Se observó la asociación entre CV global con factores sociodemográficos, clínicos y físicos; finalmente, por medio de análisis multivariado. Resultados: El 80,3% fueron mujeres, la mediana de edad de 43 años (RIC= 51-35). La fatiga fue el síntoma más frecuente ((71%). Los factores de riesgo para tener peor CV fueron: sexo femenino (RP=6,92. IC 95% 1,8-26,58), alteración en control de esfínteres (RP= 6,10 IC 95% 1,26-29,51), trastornos cognitivos (RP=4,46 IC 95% 1,07-18,56), riesgo de depresión (RP= 3,82 IC 95% 1,01-14,38) y no realizar fisioterapia (RP= 4,48 IC 95% 1,08-18,34). Conclusiones: La afectación de CV en la EM, según factores sociodemográficos y clínicos es variable. Evaluar la CVRS en la práctica clínica, permite entender el comportamiento y necesidades del paciente para intervenir factores de riesgo.

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Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis

Cited by 72 publications

References 29 publications

Contributing factors to health‐related quality of life in multiple sclerosis

Contributing factors to health‐related quality of life in multiple sclerosis

Factors Influencing Health-Related Quality of Life of Patients with Multiple Sclerosis and Their Caregivers

Calidad de vida en pacientes con esclerosis múltiple atendidos en una institución de salud de Medellín, Colombia

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