Determinants of pulse wave velocity trajectories from youth to young adulthood

Chen

Qü

et al. 2020

Preprint

To explore the prevalence of and risk factors for glycolipid metabolism disorder (GLMD) from the prenatal period through childhood and adolescence. A bidirectional cohort study which was established in 2014 and followed between March 1 and July 20, 2019 were designed to evaluate the risk factors for GLMD. Two stage stratified cluster sampling was used to include participants from four communities in two counties in Chongqing. 2808 healthy children aged between 6 and 9 years in 2014 entered the cohort in 2014, and followed in 2019 with a follow-up rate of 70%. 2,136 samples (aged 11·68 ± 0·60 years) were included. The prevalence of insulin resistance (IR), prediabetes/diabetes and dyslipidemia was 21·02%, 7·19% and 21·61%, respectively. Subjects with an urban residence, no pubertal development, dyslipidemia in 2014, higher family income, higher parental education, low quality of life (QoL), and unstable neurotic and psychotic personalities had significantly elevated fasting insulin (FI) or homeostasis model assessment insulin resistance (HOMA-IR) levels; subjects with female sex, no pubertal development, dyslipidemia in 2014, obesity, gestational hypertension, maternal weight gain above Institute of Medicine guidelines, single parents, low QoL, introverted and unstable personality had increased triglyceride or triglyceride/high-density lipoprotein (HDL). Adolescent with rural residence and living convenience had higher HbA1c level. We observed that low QoL status, unstable and psychotic personality traits were associated with increased GLMD risk independent of obesity, suggesting that the community intervention to improve the QoL and psychological health of children is essential.

Section: Discussionsupporting

confidence: 62%

The Determinants for Adolescent Glycolipid Metabolism Disorder from Prenatal Period through Adolescence: a Cohort Study

Chen

Qü

et al. 2020

Preprint

“…Elevated blood pressure level during childhood and adolescence is a recognized predictor of adulthood BP, leading to increased CVD disease in adults [1,2]. It is imperative to study the prevalence and risk factors for childhood and adolescents' hypertension, especially in low social economic status (SES) population.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Childhood Hypertension in Urban-Rural Areas of China: A Cross-Sectional Study

International Journal of Hypertension

Xiao

Luo

et al. 2020

Self Cite

Objective. The increased blood pressure level in children and adolescents is recognized as an essential predictor of adulthood cardiovascular disease. This study aimed to ascertain the prevalence and the urban-rural disparity of childhood hypertension in the southwest of China. Methods. Using stratified cluster sampling in urban and rural areas, a total of 13597 primary school children aged 6∼12 years living in the Southwest of China were included. The prevalence of hypertension was analyzed. The risk factors were collected by questionnaires, and the risk factors of childhood hypertension were analyzed by the logistic regression model. Results. The prevalence of hypertension was 13.75%, 9.02%, and 17.47% in total, urban, and rural children, respectively, and the urban-rural difference was 8.44% (95%CI: 7.32%, 9.56%). Children with obesity, maternal gestational hypertension, >10 months of breastfeeding, or low family income had a significantly increased prevalence of hypertension (29.4%, 20.00%, 16.31%, and 16.25%, respectively). Rural residence, intake of more pickle (in rural), maternal gestational hypertension (in urban), low birth weight (in rural), obesity, increased heart rate, and red blood cell counts were the risk factors of childhood hypertension. The adjusted R2 values were 13.61%, 23.25%, 10.88%, 11.12%, 12.23%, and 25.04% in the full models excluding and including serum indexes for total, urban, and rural children, respectively. Conclusions. The prevalence of childhood hypertension is significant in the Southwest of China and alarming in rural areas, which requires community intervention. Children living in rural areas combined with obesity, low social economic status, dietary imbalance, and abnormal lipid metabolism were associated with an increased risk of hypertension, and routine care programs should be conducted to prevent childhood hypertension.

“…Details of the physical examination have been described previously [ 23 ]. The mean arterial pressure (MAP) was calculated as 1/3 systolic blood pressure plus 2/3 diastolic blood pressure [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence rates of overweight and obesity were 11.7% and 6.8%, respectively, in 2011–2015 among children and adolescents in China [ 3 ]; the prevalence continues to increase, particularly in urban areas, and is accompanied by an increase in family income and changes in modern lifestyles [ 3 ]. A long-term cohort study found that obesity is the risk factor most strongly associated with a large carotid intima media thickness (cIMT) and an increased pulse wave velocity (PWV) in young adulthood [ 4 , 5 ], and a large cIMT is an index of an increased risk of cardiovascular disease (CVD) in adulthood. Additionally, children and adolescents with obesity may have psychiatric disorders [ 6 ], which may increase the risk of suicide and antisocial behavior in adolescents and adulthood.…”

Section: Introductionmentioning

confidence: 99%

The relationship between socioeconomic status and childhood overweight/obesity is linked through paternal obesity and dietary intake: a cross-sectional study in Chongqing, China

Chen

Luo

Environ Health Prev Med

et al. 2021

Self Cite

Background The prevalence of obesity and overweight in childhood has increased dramatically over the past decades globally. Thus, the risk factors of overweight and obesity in children and adolescents must be studied. Objectives This study aimed to reveal the prevalence of childhood obesity and examine the relationship between socioeconomic status (SES) and z-body mass index (z-BMI) via parental obesity and dietary intake using path analysis. Methods Stratified cluster sampling was used to select 17,007 participants aged 6–12 years on two avenues per region in urban, suburban, and rural areas. Path analysis was conducted to examine the mediators between SES and z-BMI. Results The prevalence rates of overweight and obesity were 13.36% and 8.60%, respectively, and were positively correlated with the father’s education level, family income, a birth weight > 3000g, a parental obesity history, vegetable intake and red meat intake (all P < 0.05). Four mediators (paternal obesity history, red meat intake, vegetable intake, and nutritional supplements) were observed, and the four path analyses were significant (all P < 0.05). The adjusted total effects on z-BMI were significant for income (βTot = 0.03; P < 0.01), father’s education (βTot = 0.05; P < 0.001), and region (βTot = 0.11; P<0.001), and the total mediation effects were 20.69%, 16.67%, and 5.36%, respectively. All the variables accounted for 12.60% of the z-BMI variance. Conclusions The prevalence of overweight/obesity in children was notable, and the relationship between SES and z-BMI was mediated by paternal obesity history and dietary intake.