Determinants of poor 1‐year outcome of DSM‐III‐R major depression in the general population: results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS)

Spijker, Jan; Bijl, Rob; Graaf, Ron de; Nolen, Willem A.

doi:10.1034/j.1600-0447.2001.103002122.x

Cited by 218 publications

(171 citation statements)

References 35 publications

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“…In line with this hypothesis, studies have found that anhedonia can precede the onset of depression (Dryman and Eaton, 1991); shows temporal stability (Oquendo et al, 2004); predicts poor outcome 12 months later (Spijker et al, 2001); and is associated with dysfunctions within the brain reward system (Keedwell et al, 2005;Tremblay et al, 2002). Moreover, reward dependence, a putatively heritable trait associated with maintenance of behavior in response to reward cues, shows trait-like features associated with familiality of depression (Farmer et al, 2003).…”

Section: Discussionmentioning

confidence: 88%

“…These dysfunctions may in turn foster the generation, maintenance, and/or exacerbation of depressive symptoms, particularly lack of interest in the environment and loss of pleasure. Studies using self-report measures have indeed shown that anhedonia and blunted behavioral activation predicted (1) future depressive symptoms (Hundt et al, 2007;Kimbrel et al, 2007), (2) course of depression and time to recovery (McFarland et al, 2006), and (3) poor treatment outcome 8-12 months later (Kasch et al, 2002;Spijker et al, 2001). Moreover, low positive affect has been identified as a risk factor for the development and maintenance of depressive symptoms in children (Hayden et al, 2006;Joiner and Lonigan, 2000;Lonigan et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

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Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Pizzagalli

Iosifescu

Hallett

et al. 2008

Journal of Psychiatric Research

647

693

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Objective-Anhedonia, the lack of reactivity to pleasurable stimuli, is a cardinal feature of depression that has received renewed interest as a potential endophenotype of this debilitating disease. The goal of the present study was to test the hypothesis that individuals with major depression are characterized by blunted reward responsiveness, particularly when anhedonic symptoms are prominent.Methods-A probabilistic reward task rooted within signal-detection theory was utilized to objectively assess hedonic capacity in 23 unmedicated subjects meeting DSM-IV criteria for major depressive disorder (MDD) and 25 matched control subjects recruited from the community. Hedonic capacity was defined as reward responsiveness -i.e., the participants' propensity to modulate behavior as a function of reward.Results-Compared to controls, MDD subjects showed significantly reduced reward responsiveness. Trial-by-trial probability analyses revealed that MDD subjects, while responsive to delivery of single rewards, were impaired at integrating reinforcement history over time and expressing a response bias toward a more frequently rewarded cue in the absence of immediate reward. This selective impairment correlated with self-reported anhedonic symptoms, even after considering anxiety symptoms and general distress.Conclusions-These findings indicate that MDD is characterized by an impaired tendency to modulate behavior as a function of prior reinforcements, and provides initial clues about which aspects of hedonic processing might be dysfunctional in depression.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Pizzagalli

Iosifescu

Hallett

et al. 2008

Journal of Psychiatric Research

647

693

View full text Add to dashboard Cite

show abstract

“…Educational level was also omitted because it potentially confounds with other variables that may be of influence on course. 20 Inclusion of all these variables would call for unacceptable complex analyses given the small sample size.…”

Section: Discussionmentioning

confidence: 99%

Autobiographical memory specificity and the course of major depressive disorder

Peeters

Wessel

Merckelbach

et al. 2002

Comprehensive Psychiatry

144

105

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This study examined the stability of autobiographical memory dysfunction (i.e., difficulties in retrieving specific memories) during the course of major depressive disorder, its relation to early adverse experiences, and its influence on the course of depressive disorder. Using the Autobiographical Memory Test (AMT), specificity of autobiographical memory was assessed in 25 subjects with a current depressive disorder at baseline, and at 3 and 7 months follow-up. Also, information about self-reported childhood traumatization, and demographic and clinical variables was obtained. Autobiographical memory performance was relatively stable over time despite clinical improvement in the sample. It was not related to depression severity at baseline, while higher levels of childhood traumatization were correlated with more specific memory performance to negative cue words at baseline, but not during follow-up. Specific autobiographical responses to negative cue words predicted a better prognosis, whereas specific responses to positive cue words were not related to prognosis. Autobiographical memory dysfunction in depression appears to be stable over time, is related to short-term prognosis in depression, and may act as a vulnerability factor that influences the long-term course of depressive disorders.

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“…It is important to investigate the role of anhedonia in pain, because it specifically predicts worse treatment outcome [32] and a longer and more severe course of depression [33]. The purpose of the current study was to examine whether BDNFTrkB signaling might contribute to the individual differences in anhedonia-like phenotype in rats after spared nerve injury (SNI).…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury

Fang

Yang

et al. 2018

Eur Arch Psychiatry Clin Neurosci

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Although depressive symptoms including anhedonia (i.e., loss of pleasure) frequently accompany pain, little is known about the risk factors contributing to individual differences in pain-induced anhedonia. In this study, we examined if signaling of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-receptor-kinase B (TrkB) contribute to individual differences in the development of neuropathic pain-induced anhedonia. Rats were randomly subjected to spared nerved ligation (SNI) or sham surgery. The SNI rats were divided into two groups based on the results of a sucrose preference test. Rats with anhedonia-like phenotype displayed lower tissue levels of BDNF in the medial prefrontal cortex (mPFC) compared with rats without anhedonia-like phenotype and sham-operated rats. In contrast, tissue levels of BDNF in the nucleus accumbens (NAc) of rats with an anhedonia-like phenotype were higher compared with those of rats without anhedonia-like phenotype and sham-operated rats. Furthermore, tissue levels of BDNF in the hippocampus, L2-5 spinal cord, muscle, and liver from both rats with or without anhedonia-like phenotype were lower compared with those of sham-operated rats. A single injection of 7,8-dihydroxyflavone (10 mg/kg; TrkB agonist), but not ANA-12 (0.5 mg/kg; TrkB antagonist), ameliorated reduced sucrose preference and reduced BDNF-TrkB signaling in the mPFC in the rats with anhedonia-like phenotype. These findings suggest that reduced BDNF-TrkB signaling in the mPFC might contribute to neuropathic pain-induced anhedonia, and that TrkB agonists could be potential therapeutic drugs for pain-induced anhedonia.

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Determinants of poor 1‐year outcome of DSM‐III‐R major depression in the general population: results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS)

Abstract: Poor outcome of major depression is frequent in the general population. Largely the same risk factors are involved as in clinical populations.

Cited by 218 publications

References 35 publications

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Autobiographical memory specificity and the course of major depressive disorder

Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury

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