Determinants of Perimacular Inner Retinal Layer Thickness in Normal Eyes Measured by Fourier-Domain Optical Coherence Tomography

Abstract

Inner retinal layer thickness, as measured by FD-OCT, varies significantly with age and axial length. The effect is small but clinically relevant in the interpretation of inner retinal layer thickness measurements.

Comparison of macular ganglion cell complex thickness to total retinal thickness ratio between Hungarian and Japanese eyes

“…They found that GCC thickness significantly decreases with age [23]. This result is consistent with the previously published histological findings on human retina that demonstrate a decrease in the density of photoreceptors, retinal ganglion cells and retinal pigment epithelial cells with increasing age [39].…”

“…Using the RTVue-100 OCT Kim et al [23] examined 182 healthy subjects with ages ranging between 22 and 84 years. They found that GCC thickness significantly decreases with age [23].…”

“…The diagnostic accuracy of the various GCC parameters, however, might be improved if a parameter less variable than average GCC thickness could be used for the software-provided automatic classification. In healthy eyes GCC thickness varies between 76.6 and 119.8 lm [21], and is influenced by axial length, age and race [23][24][25]. In order to further improve the diagnostic ability of the inner macular thickness parameters of the RTVue-100 OCT, Kita and colleagues introduced a new parameter, the ratio of GCC thickness to total retinal thickness (G/T ratio) [26].…”

Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole

“…4,[12][13][14] The GCC thickness obtained from the unaffected fellow eyes was 94.7 ± 5.4 mm, which is comparable to that in other studies. The postoperative GCC thickness in our study was 84.2 ± 10.8 mm at 6 months, and it was thinner than normal GCC thickness by approximately 10 mm.…”

Association between retinal neuronal degeneration and visual function impairment in type 2 diabetic patients without diabetic retinopathy

“…Therefore, in our study the peripapillary RNFL and macular GCC thicknesses were measured by SD OCT to detect early neuronal degeneration. It is well known that RNFL and GCC thicknesses decreased with age [18,19]. As shown in Table 1, there was no significant difference with respect to age between diabetic and normal subjects.…”